Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after chernobyl and analysis of the involved RET-fused gene RFG5

Cancer Research

Volumn 58, Issue 2, 1998, Pages 198-203

  Klugbauer, Sabine ^a   Demidchik, Evgenij P ^b   Lengfelder, Edmund ^a   Rabes, Hartmut M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b BELARUSIAN STATE MEDICAL UNIVERSITY   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN;

ARTICLE; CASE REPORT; CHERNOBYL ACCIDENT; COMPUTER ANALYSIS; CONTROLLED STUDY; FEMALE; GENE ISOLATION; GENE REARRANGEMENT; GENE SEGREGATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; THYROID PAPILLARY CARCINOMA;

ACCIDENTS, RADIATION; ADULT; AMINO ACID SEQUENCE; ARTIFICIAL GENE FUSION; BASE SEQUENCE; BLOTTING, NORTHERN; CARCINOMA, PAPILLARY; CHILD; DNA PROBES; DNA, NEOPLASM; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NEOPLASMS, RADIATION-INDUCED; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; THYROID NEOPLASMS; UKRAINE;

EID: 0031964510     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Rabes, H. M., and Klugbauer, S. Radiation-induced thyroid carcinomas in children: high prevalence of RET rearrangement. Verh. Dtsch. Ges. Pathol., 139-144, 1997.
2. Klugbauer, S., Lengfelder, E., Demidchik, E. P., and Rabes, H. M. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene, 11: 2459-2467, 1995.
3. Fugazzola, L., Pilotti, S., Pinchera, A., Vorontsova, T. V., Mondellini, P., Bongarzone, I., Greco, A., Astakhova, L., Butti, M. G., Demidchik, E. P., Pacini, F., and Pierotti, M. A. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident. Cancer Res., 55: 5617-5620, 1995.
4. Nikiforov, Y. E., Rowland, J. M., Bove, K. E., Monforte-Munoz, H., and Fagin, J. A. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res., 57: 1690-1694, 1997.
5. Jhiang, S. M., Smanik, P. A., and Mazzaferri, E. L. Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma. Cancer Lett., 78: 69-76, 1994.
6. Klugbauer, S., Lengfelder, E., Demidchik, E. P., and Rabes, H. M. A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident. Oncogene, 13: 1099-1102, 1996.
7. Klugbauer, S., Demidchik, E. P., Lengfelder, E., and Rabes, H. M. Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and break-points in papillary thyroid carcinoma of children after Chernobyl. Oncogene, in press, 1998.
8. Fugazzola, L., Pierotti, M., Vigano, E., Pacini, F., Verontsova, T., and Bongarzone, I. Molecular and biochemical analysis of RET/PTC4, a novel oncogeneic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer. Oncogene, 13: 1093-1097, 1996.
9. Grieco, M., Santoro, M., Berlingieri, M. T., Melillo, R. M., Donghi, R., Bongarzone, I., Pierotti, M. A., Della Porta, G., Fusco, A., and Vecchio, G. PTC is a novel rearranged form of the ret proto oncogene and is frequently detected in vivo in human thyroid papillary carcinoma. Cell, 60: 557-663, 1990.
10. Bongarzone, I., Monzini, N., Borrello, M. G., Carcano, C., Ferraresi, G., Arighi, E., Mondellini, P., Della Porta, G., and Pierotti, M. A. Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RIα of cyclic AMP-dependent protein kinase A. Mol. Cell. Biol., 13: 358-366, 1993.
11. Ishizaka, Y., Ochiai, M., Tahira, T., Sugimura, T., and Nagao, M. Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing. Oncogene, 4: 789-794, 1989.
12. Altshul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. Basic local alignment search tool. J. Mol. Biol., 215: 403-410, 1990.
13. Furmanchuk, A., Averkin, J. I., Egloff, B., Ruchti, C., Abelin, T., Schäppi, W., and Korotkevich, E. A. Pathomorphological findings in thyroid cancers of children from the Republic of Belarus: a study of 86 cases occurring between 1986 (post-Chernobyl) and 1991. Histopathology (Oxf.), 21: 401-408, 1992.
14. Nikiforov, Y., and Gnepp, D. R. Pediatric thyroid cancer after the Chernobyl disaster. Cancer (Phila.), 74: 748-766, 1994.
15. Takahashi, M., Buma, Y., Iwamoto, T., Inaguma, Y., Ikeda, H., and Hiai, H. Cloning and expression of the ret proto oncogene coding a tyrosine kinase with two potential transmembrane domains. Oncogene, 3: 571-578, 1988.
16. Sozzi, G., Bongarzone, I., Miozzo, M., Cariani, C. T., Mondellini, P., Calderone, C., Pilotti S., Pierotti, M. A., and Della Porta, G. Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. Genes Chromosomes Cancer, 5: 212-218, 1994.
17. Pierotti, M. A., Santoro, M., Jenkins, R. B., Sozzi, G., Bongarzone, I., Grieco, M., Monzini, N., Miozzo, M., Herrmann, M. A., Fusco, A., Hay, I. D., Della Porta, G., and Vecchio, G. Characterization of an inversion on the long arm of chromosome 10 juxtaposes D10S170 and ret and creating the oncogenic sequence ret/ptc. Proc. Natl. Acad. Sci. USA, 89: 1616-1620, 1992.
18. Minoletti, F., Butti, M. G., Coronelli, S., Miozzo, M., Sozzi, G., Pilotti, S., Tunnacliffe, A., Pierotti, M. A., and Bongarzone, I. The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2. Genes Chromosomes Cancer, 11: 51-57, 1994.
19. Rodrigues, G. A., and Park, M. Oncogenic activation of tyrosine kinases. Curr. Opin. Genet. Dev., 13: 6711-6722, 1993.
20. Kyte, J., and Doolittle, R. F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol., 157: 105-132, 1982.
21. Lupas, A., Van Dyke, M., and Stock, J. Predicting coiled coils from protein sequences. Science (Washington DC), 252: 1162-1164, 1991.
22. Rodrigues, G. A., and Park, M. Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Mol. Cell. Biol., 13: 6711-6722, 1993.
23. Tong, Q., Xing, S., and Jhiang, S. J. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity. J. Biol. Chem., 272(4): 9043-9047, 1997.
24. Durick, K., Yao, V. J., Borrello, M. G., Bongarzone, I., Pierotti, M. A., and Taylor, S. S. Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2. J. Biol. Chem., 270: 24642-24645, 1995.
25. Geurts, J. M. W., Schoenmakers, E. F. P. M., Roijer, E., Stenman, G., and Van de Ven, W. J. M. Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. Cancer Res., 57: 13-17, 1997.
26. Ito, T., Seyama, T., Iwamoto, K. S., Hayashi, T., Mizuno, T., Tsuyama, N., Dohi, K., Nakamura, N., and Akiyama, M. In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res., 53: 2940-2943, 1993.