Lipolytic modification of LDL by phospholipase A2 induces particle aggregation in the absence and fusion in the presence of heparin

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 5, 1999, Pages 1276-1283

  Hakala, Jukka K ^a   Öörni, Katariina ^a   Ala Korpela, Mika ^a   Kovanen, Petri T ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

Author keywords

Aggregation; Fusion; Heparin; LDL; Phospholipase A2

Indexed keywords

FAT DROPLET; GLYCOSAMINOGLYCAN; HEPARIN; PHOSPHOLIPASE A2;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FOAM CELL; HUMAN; INTIMA; LIPOLYSIS; LIPOPROTEIN METABOLISM; PRIORITY JOURNAL;

EID: 0345593601     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.5.1276     Document Type: Article

References (49)

1. Frank JS, Fogelman AM. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J Lipid Res. 1989;30:967-978.
2. Nievelstein PF, Fogelman AM, Mottino G, Frank JS. Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue. Arterioscler Thromb. 1991;11:1795-1805.
3. Nievelstein-Post P, Mottino G, Fogelman AM, Frank JS. An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit. Arterioscler Thromb. 1994;14:1151-1161.
4. Pasquinelli G, Preda P, Vici M, Gargiulo M, Stella A, D'Addato M, Laschi R. Electron microscopy of lipid deposits in human atherosclerosis. Scanning Microsc. 1989;3:1151-1159.
5. Tirziu D, Dobrian A, Tasca C, Simionescu M, Simiunescu N. Intimal thickening of human aorta contain modified reassembled lipoproteins. Atherosclerosis. 1995;112:101-114.
6. Smith EB. The relationship between plasma and tissue lipids in human atherosclerosis. Adv Lipid Res. 1974;12:1-14.
7. Brown M, Ho Y, Goldstein J. The cholesteryl ester cycle in macrophage foam cells: Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. J Biol Chem. 1980;255:9344-9352.
8. Guyton JR, Klemp KF, Black BL, Bocan TM. Extracellular lipid deposition in atherosclerosis. Eur Heart J. 1990;11:20-28.
9. Kruth HS. The fate of lipoprotein cholesterol entering the arterial wall. Curr Opin Lipidol. 1997;8:246-252.
10. Paananen K, Kovanen PT. Proteolysis and fusion of low density lipoprotein particles independently strengthen their binding to exocytosed mast cell granules. J Biol Chem. 1994;269:2023-2031.
11. Piha M, Lindstedt L, Kovanen PT. Fusion of proteolyzed low-density lipoprotein in the fluid phase: A novel mechanism generating atherogenic lipoprotein particles. Biochemistry. 1995;34:10120-10129.
12. Pentikäinen MO, Lehtonen EMP, Kovanen PT. Aggregation and fusion of modified low density lipoprotein. J Lipid Res. 1996;37:2638-2649.
13. Xu X, Tabas I. Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages. J Biol Chem. 1991;266:24849-24858.
14. Suits AG, Chait A, Aviram M, Heinecke JW. Phagosytosis of aggregated lipoprotein by macrophages: Low density lipoprotein receptor-dependent foam-cell formation. Proc Natl Acad Sci U S A. 1989;86:2713-2717.
15. Liu H, Scraba DG, Ryan RO. Prevention of phosphohpase-C induced aggregation of low density lipoprotein by amphipathic apolipoproteins. FEBS letters. 1993;316:27-33.
16. Camejo G, Hurt E, Romano M. Properties of lipoprotein complexes isolated by affinity chromatography from human aorta. Biomed Biochim Acta. 1985;44:389-401.
17. Daugherty A, Zweifel BS, Sobel BE, Schonfeld G. Isolation of low density lipoprotein from atherosclerotic vascular tissue of watanabe heritable hyperlipidemic rabbits. Arteriosclerosis. 1988;8:768-777.
18. Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;84:1086-1095.
19. Chao F, Blanchette-Mackie FJ, Chen Y, Dickens BF, Berlin E, Amende LM, Skarlatos SI, Gample W, Resau JH, Mergner WT, Kruth HS. Characterization of two unique cholesterol-rich lipid particles isolated from human atherosclerotic lesions. Am J Pathol. 1990;136:169-179.
20. Tailleux A, Torpier G, Caron B, Fruchart J-C, Fievet C. Immunological properties of apoB-containing lipoprotein particles in human atherosclerotic arteries. J Lipid Res. 1993;34:719-728.
21. 2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity. J Biol Chem. 1996;271:26307-26314.
22. 2 in human atherosclerotic plaques. Atherosclerosis. 1995;118:173-181.
23. 2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins. Arterioscler Thromb Vasc Biol. 1997;17: 300-309.
24. 2 in atherosclerotic and nonatherosclerotic regions of human arteries. Arterioscler Thromb Vasc Biol. 1998;18:519-525.
25. 2 only aggregation, of low density lipoprotein particles. J Biol Chem. 1998;273: 29127-29134.
26. Camejo G, Hurt E, Wiklund O, Rosengren B, Lopez F, Bondjers G. Modification of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6-sulfate. Biochim Biophys Acta. 1991;1096:253-261.
27. Pentikäinen MO, Lehtonen EMP, Öörni K, Lusa S, Somerharju P, Jauhiainen M, Kovanen PT. Human arterial proteoglycans increase the rate of proteolytic fusion of low density lipoprotein particles. J Biol Chem. 1997;272:25283-25288.
28. Hurt-Camejo E, Camejo G, Rosengren B, López F, Ahlström C, Fager G, Bondjers G. Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells. Arterioscler Thromb. 1992;12:569-583.
29. Bihari-Varga M, Camejo G, Christiane-Horn M, Szabo D, López F, Gruber E. Structure of low density lipoprotein in complexes formed with arterial matrix components. Int J Biol Macromol. 1983;5:59-65.
30. Mateu L, Àvila EM, Leòn V, Liscano N. The structural stability of lo-density lipoprotein. A kinetic X-ray scattering study of its interaction with arterial proteoglycans. Biochim Biophys Acta. 1984;795:525-534.
31. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345-1353.
32. Radding CM, Steinberg D. Studies on the synthesis and secretion of serum lipoproteins by rat liver slices. J Clin Invest. 1960;39:1560-1569.
33. 125I-containing acylating agent. Biochem J. 1973;133:529-539.
34. Kovanen PT, Kokkonen JO. Modification of low density lipoproteins by secretory granules of rat serosal mast cells. J Biol Chem. 1991;266: 4430-4436.
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
36. Forte T, Nichols AV. Application of electron microscopy to the study of plasma lipoprotein structure. Adv Lipid Res. 1972;10:1-42.
37. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-917.
38. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
39. 2 alters the expression of selected apo B-100 epitopes and the interaction of LDL with cells. J Lipid Res. 1988;29:729-743.
40. 2. A spin-label study. Biochim Biophys Acta. 1996;1300:103-113.
41. 2. J Biol Chem. 1976;251:3823-3830.
42. Lottin H, Motta C, Simard G. Differential effects of glycero- and sphingophospholipolysis on human high-density lipoprotein fluidity. Biochim Biophys Acta. 1996;1301:127-132.
43. Camejo G, Hurl E, Bondjers G. Effect of proteoglycans on lipoprotein-cell interactions: possible contribution to atherogenesis. Curr Opin Lipidol. 1990;1:431.
44. Cherchi G, Formato M, Demuro P, Masserini M, Varani I, DeLuca G. Modification of low density lipoprotein induced by the interaction with human plasma glycosaminoglycan-protein complexes. Biochim Biophys Acta. 1994;1212:345-352.
45. Hurt-Camejo E, Olsson U, Wiklund O, Bondjers G, Camejo G. Cellular consequences of the association of apoB lipoproteins with proteoglycans. Potential contribution to atherogenesis. Arterioscler Thromb Vasc Biol. 1997;17:1011-1017.
46. Guyton JR, Klemp KF. Development of lipid-rich core in human atherosclerosis. Arterioscler Thromb Vasc Biol. 1996;16:4-11.
47. Hoff HF, O'Neil J. Lesion derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation. Arterioscler Thromb. 1991;11: 1209-1222.
48. 2 mimics cell-mediated oxidative modification. J Lipid Res. 1988;29: 745-753.
49. Schissel SL, Jiang X, Tweedie-Hardman J, Jeong T, Hurt-Camejo E, Najib J, Rapp JH, Williams KJ, Tabas I. Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. J Biol Chem. 1998;273:2738-2746.