Role of chemokines in the regulation of Th1/Th2 and autoimmune encephalomyelitis

Journal of Clinical Immunology

Volumn 19, Issue 5, 1999, Pages 273-279

  Kennedy, Kevin J ^a   Karpus, William J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autoimmunity; Chemokine; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Review; T helper cells

Indexed keywords

CELL ADHESION MOLECULE; CHEMOATTRACTANT; CHEMOKINE; CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOTOXIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; STAT4 PROTEIN; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; CELL MIGRATION; HELPER CELL; HUMAN; INFLAMMATORY CELL; MONOCYTE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

ANIMALS; CHEMOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; TH1 CELLS; TH2 CELLS;

EID: 0032832699     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020535423465     Document Type: Review

References (64)

1. 1. Amason BG: Relevance of experimental allergic encephalomyelitis to multiple sclerosis. Neurol Clin 1:765-782, 1983
2. 2. McRae BL, Kennedy MK, Tan LJ, Dal Canto MC, Miller SD: Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J Neuroimmunol 38:229-240, 1992
3. 3. Tuohy VK, Sobel RA, Lu Z, Laursen RA, Lees MB: Myelin proteolipid protein: minimum sequence requirements for active induction of autoimmune encephalomyelitis in SWR/J and SJL/J mice. J Neuroimmunol 39:67-74, 1992
4. 4. Whitham RH, Bourdette DN, Hashim GA, Herndon RM, Ilg RC, Vandenbark AA, Offner H: Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis. J Immunol 146:101-107, 1991
5. 5. Hickey WF, Gonatas NK, Kimura H, Wilson DB: Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis. J Immunol 131:2805-2809, 1983
6. 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab Invest 63:162-170, 1990
7. - T cell-mediated pathology. J Immunol 156:4050-4058, 1996
8. 8. Baggiolini M, Dewald B, Moser B: Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv Immunol 55:97-179, 1994
9. 9. Luster AD: Chemokines - Chemotactic cytokines that mediate inflammation. N Engl J Med 338:436-445, 1998
10. 10. Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ, Zlotnik A: Lymphotactin: A cytokine that represents a new class of chemokine. Science 266:1395-1399, 1994
11. 11. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ: A new class of membrane-bound chemokine with a CX,C motif. Nature 385:640-644, 1997
12. 12. Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Van Damme J, Walz A, Marriott D, Chan SY, Roczniak S, Shanafelt AB: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270:27348-27357, 1995
13. 13. Davatelis G, Tekamp-Olson P, Wolpe SD, Hermsen K, Luedke C, Gallegos C, Coit D, Merryweather J, Cerami A: Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokine properties. J Exp Med 167:1939-1944, 1988
14. 14. Schall TJ: Biology of the RANTES/SIS cytokine family. Cytokine 3:165-183, 1991
15. + T cells in response to MIP-1α and MIP-1β. Science 260:355-358, 1993
16. 16. Hedrick JA, Saylor V, Figueroa D, Mizoue L, Xu YM, Menon S, Abrams J, Handel T, Zlotnik A: Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo. J Immunol 158:1533-1540, 1997
17. 17. Mosmann TR, Coffman RL: Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145-174, 1989
18. 18. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 383:787-793, 1996
19. 19. Bradley LM, Asensio VC, Schioetz LK, Harbertson J, Krahl T, Patstone G, Woolf N, Camphell IL, Sarvetnick N: Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol 162:2511-2520, 1999
20. 20. Schrum S, Probst P, Fleischer B, Zipfel PF: Synthesis of the CC-chemokines MIP-1α, MIP-1β, and RANTES is associated with a type 1 immune response. J Immunol 157:3508-3604, 1996
21. 21. Li L, Xia Y, Nguyen A, Feng L, Lo D: Th2-induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation. J Immunol 161:3128-3135, 1998
22. 22. Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA: Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 159:4150-4153, 1997
23. 23. Lukacs NW, Kunkel SL, Strieter RM, Warmington K, Chensue SW: The role of macrophage inflammatory protein 1α in Shistosoma mansoni egg-induced granulomatous inflammation. J Exp Med 177:1551-1559, 1993
24. 24. Chensue SW, Warmington KS, Lukacs NW, Lincoln PM, Burdick MD, Strieter RM, Kunkel SL: Monocyte chemotactic protein expression during schistosome egg granuloma formation. Sequence of production, localization, contribution, and regulation. Am J Pathol 146:130-138, 1995
25. 25. Lukacs NW, Chensue SW, Karpus WJ, Lincoln P, Keefer C, Strieter RM, Kunkel SL: C-C chemokines differentially alter interleukin-4 production from lymphocytes. Am J Pathol 150: 1861-1868, 1997
26. 26. Karpus WJ, Lukacs NW, Kennedy KJ, Smith WS, Hurst SD, Barrett TA: Differential CC chemokine-induced enhancement of T helper cell cytokine production. J Immunol 158:4129-4136, 1997
27. 27. Kim CH, Broxmeyer HE: Chemokines: Signal lamps for trafficking of T and B cells for development and effector function. J Leukoc Biol 65:6-15, 1999
28. 28. Ward SG, Bacon K, Westwick J: Chemokines and T lymphocytes: More than an attraction. Immunity 9:1-11, 1998
29. 29. Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G: Cutting edge: Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J Immunol 162; 5671-5675, 1999
30. 30. Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O: Molecular cloning of a novel human CC chemokine EBH-ligand chemokine that is a specific functional ligand for EBH, CCR7. J Biol Chem 272:13803-13809, 1997
31. 31. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR: The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 94:1925-1930, 1997
32. 32. Loetscher P, Seitz M, Baggiolini M, Moser B: Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 184:569-577, 1996
33. 33. Baggiolini M: Chemokines and leukocyte traffic. Nature 392:565-568, 1998
34. 34. Sallusto F, Mackay CR, Lanzavecchia A: Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277:2005-2007, 1997
35. 35. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187:875-883, 1998
36. 36. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA: High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J Clin Invest 100:1137-1143, 1997
37. 37. Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard, Mackay CR: Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils [see comments]. J Exp Med 183:2437-2448, 1996
38. 38. Imai T, Nagira M, Takagi S, Kukizaki M, Nishimura M, Wang J, Gray PW, Mutsushima K, Yoshie O: Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 11:81-88, 1999
39. 39. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type I T helper cells (Th1s) and Th2s. J Exp Med 187:129-134, 1998
40. 40. Luster AD, Ravetch JV: Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). J Exp Med 166:1084-1097, 1987
41. 41. Farber JM: Mig and IP-10: CXC chemokines that target lymphocytes. J Leukocyte Biol 61:246-257, 1997
42. 42. Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K: Interferon-inducible T cell alpha chemoattractant (I-TAC): A novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med 187:2009-2021, 1998
43. 43. Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, Dayer JM: CCR5 is characteristic of Th1 lymphocytes. Nature 391:344-345, 1998
44. 44. Siveke JT, Hamann A: T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol 160:550-554, 1998
45. 45. Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammalory reactions. J Clin Invest 101:746-754, 1998
46. + T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci USA 96:6873-6878, 1999
47. 47. Sorensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik VA, Qin S, Rottman J, Sellebjerg E, Strieter RM, Frederiksen JL, Ransohoff RM: Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103:807-815, 1999
48. 48. Bennetts BH, Teutsch SM, Buhler MM, Heard RN, Stewart GJ: The CCR5 deletion mutation fails to protect against multiple sclerosis. Hum Immunol 58:52-59, 1997
49. 49. Jiang Y, Salafranca MN, Adhikari S, Xia Y, Feng L, Sonntag MK, deFiebre CM, Pennell NA, Streit WJ, Harrison JK: Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. J Neuroimmunol 86:1-12, 1998
50. 50. Hulkower K, Brosnan CF, Aquino DA, Cammer W, Kulshrestha S, Guida MP, Rapoport DA, Berman JW: Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis. J Immunol 150:2525-2533, 1993
51. 51. Ransohoff RM, Hamilton TA, Tani M, Stoler MH, Shick HE, Major JA, Estes ML, Thomas DM, Tuohy VK: Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J 7:592-600, 1993
52. 52. Godiska R, Chantry D, Dietsch GN, Gray PW: Chemokine expression in murine experimental allergic encephalomyelitis. J Neuroimmunol 58:167-176, 1995
53. 53. Glabinski AR, Tani M, Tuohy VK, Tuthill RJ, Ransohoff RM: Central nervous system chemokine mRNA accumulation follows initial leukocyte entry at the onset of acute murine experimental autoimmune encephalomyelitis. Brain Behav Immun 9:315-330, 1995
54. 54. Glabinski AR, Tuohy VK, Ransohoff RM: Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis. Neuroimmunomodulation 5:166-171, 1998
55. 55. Miyagishi R, Kikuchi S, Takayuma C, Inoue Y, Tashiro K: Identification of cell types producing RANTES, MIP-1α, and MIP-1β in rat experimental autoimmune encephalomyelitis by in situ hybridization. J Neuroimmunol 77:17-26, 1997
56. 56. Glabinski AR, Tani M, Strieter RM, Tuohy VK, Ransohoff RM: Synchronous synthesis of α and β-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Am J Pathol 150:617-630, 1997
57. 57. Karpus WJ, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD: An important role for the chemokine macrophage inflammatory protein-1α in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 155:5003-5010, 1995
58. 58. Kennedy KJ, Strieter RM, Kunkel SL, Lukacs NW, Karpus WJ: Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1α and monocyte chemotactic protein-1. J Neuroimmunol 92:98-108, 1998
59. 59. Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB: Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J Immunol 142:1523-1527, 1989
60. 60. Karpus WJ, Kennedy KJ: MIP-1alpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J Leukocyte Biol 62:681-687, 1997
61. 61. Yu M, Nishiyama A, Trapp BD, Tuohy VK: Inrerferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol 64:91-100, 1996
62. 62. Ransohoff RM, Glabinski A, Tani M: Chemokines in immune-mediated inflammation of the central nervous system. Cytokine Growth Factor Rev 7:35-46, 1996
63. 63. Glabinski AR, Krakowski M, Han Y, Owens T, Ransohoff RM: Chemokine expression in GKO mice (lacking interferon-gamma) with experimental autoimmune encephalomyelitis. J Neurovirol 5:95-101, 1999
64. 64. Karpus WJ, Ransohoff RM: Chemokine regulation of experimental autoimmune encephalomyelitis: Temporal and spatial expression patterns govern disease pathogenesis. J Immunol 161:2667-2671, 1998