Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine

European Journal of Neuroscience

Volumn 8, Issue 3, 1996, Pages 446-454

  Parsons, C G ^a  

^a MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

(+) MK 801; AMPA; Concentration clamp; GABA; Ketamine; Kinetics

Indexed keywords

AMANTADINE; DIZOCILPINE; KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; CORPUS STRIATUM; HIPPOCAMPUS; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

AMANTADINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; KETAMINE; MEMANTINE; MEMBRANE POTENTIALS; N-METHYLASPARTATE; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0029971255     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb01228.x     Document Type: Article

References (2)

1. Bresink, I., Danysz, W., Parsons, C. G. and Mutschler, E. (1995) Different binding affinities of NMDA receptor channel blockers in various brain regions - indication of NMDA receptor heterogeneity. Neuropharmacology, 34, 533-540.
2. Burnashev, N., Schocpfer, R., Monyer, H., Ruppersberg, J. P., Gunther, W., Seeburg, P. H. and Sakmann, B. (1992) Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science, 257, 1415-1419.