Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils

Blood

Volumn 96, Issue 6, 2000, Pages 2199-2205

  Miura, Katsushi ^a   MacGlashan Jr , Donald W ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; HISTAMINE; IMMUNOGLOBULIN E; INTERLEUKIN 4; LEUKOTRIENE C4; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P21; PROTEIN P85;

ARTICLE; BASOPHIL; CELL STIMULATION; CROSS LINKING; CYTOKINE PRODUCTION; ENZYME REGULATION; HISTAMINE RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0034665773     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2199     Document Type: Article

References (48)

1. Cytokine generation by human basophils
2. The role of the basophil in allergic inflammation
3. Signal transduction in the activation of mast cells and basophils
4. Downstream signals initiated in mast cells by Fc epsilon RI and other receptors
5. Extracellular signal-regulated kinases (ERKs) regulate leukotriene C4 generation, but not histamine release nor interleukin-4 (IL-4) production from human basophils
6. Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils
7. Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells
8. Syk-dependent phosphorylation of Shc: A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2
9. A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor
10. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
11. Downstream of phosphatidylinositol-3 kinase, a multifunctional signaling molecule, and its regulation in cell responses
12. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
13. The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production
14. Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking
15. Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells
16. Aggregation of the FcεRI on mast cells stimulates c-Jun amino-terminal kinase activity: A response inhibited by wortmannin
17. Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils
18. Differential activation of human ha: Sophils by anti-IgE and formyl-methionyl-leucylphenylalanine: Indications for protein kinase C-dependent and -independent activation pathways
19. Characteristics of human basophil sulfidopeptide leukotriene release: Releasability defined as the ability of the basophil to respond to dimeric cross-links
20. Secretion of interleukin-4 from human basophils: The relationship between IL-4 mRNA and protein in resting and stimulated basophils
21. Expression of protein kinase C isozymes in human basophils: Regulation by physiological and nonphysiological stimuli
22. Early interleukin-4: Its role in the switch towards a Th2 response and IgE-mediated allergy
23. Basophil counting with a new staining method using Alcian blue
24. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production
25. Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: Difference in characteristics between acute and late priming effects
26. Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: Novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade
27. Cell cycle-dependent activation of Ras
28. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
29. Measuring leukotrienes of slow-reacting substance of anaphylaxis: Development of a specific radioimmuno-assay
30. An automated continuous-flow system for the extraction and fluorometric analysis of histamine
31. IgE-dependent IL-4 secretion by human basophils: The relationship between cytokine production and histamine release in mixed leukocyte cultures
32. Interleukin-3 alters free arachidonic acid generation in C5a-stimulated human basophils
33. ++ changes in human lung mast cells: Graded vs. all-or-nothing elevations after IgE-mediated stimulation
34. PI 3-kinase: A pivotal pathway in T-cell activation?
35. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: Role in activation of reduced nicotinamide adenine dinucleotide oxidase
36. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
37. The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling
38. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
39. The role of phosphoinositide 3-kinase lipid products in cell function
40. Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway
41. Phosphatidylinositol-3-OH kinase as a direct target of Ras
42. Interaction of Ras with phosphoinositide 3-kinase gamma
43. Desensitization of IgE-mediated IL-4 release from human basophils
44. ++ responses in human basophils: Evidence that the initial transient elevation associated with mobilization of intracellular calcium is an insufficient signal for degranulation
45. + mobilization in antigen-stimulated mast cells
46. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation
47. Phosphatidylinositol-3,4,5-trisphosphate (Ptdlns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
48. + following B-cell receptor activation