Isolation and quantification of fluoroacetate in rat tissues, following dosing of 2-Phe-Ala-CH2-F, a peptidyl fluoromethyl ketone protease inhibitor

Journal of Pharmaceutical and Biomedical Analysis

Volumn 16, Issue 3, 1997, Pages 459-467

  Eichhold, Thomas H ^a   Hookfin, Erin B ^a   Taiwo, Yetunde O ^a   De, Biswanath ^a   Wehmeyer, Kenneth R ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Fluoroacetate; Fluoromethyl ketones; Mass spectrometry; Proteinase inhibitors; Two dimensional gas chromatography

Indexed keywords

FLUOROACETIC ACID; PEPTIDE FLUOROMETHYL KETONE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG ISOLATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SOLID PHASE EXTRACTION;

ANIMALS; CALIBRATION; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; FLUOROACETATES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KETONES; LIVER; RATS; RODENTICIDES;

EID: 0030832784     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(97)00102-7     Document Type: Article

References (16)

1. Roughly P.J., Barrett A.J. J. Biochem. 167:1977;629-637.
2. Roughly P.J. J. Biochem. 167:1977;639-646.
3. Rasnick D. Anal. Biochem. 149:1985;461-465.
4. Ahmed N.K., Martin L.A., Watts L.M. Biochem. Pharmacol. 44:1992;1201-1207.
5. Esser R.E., Watts L.M., Angelo R.A., Thornburg L.P., Prior J.J., Palmer J.T. J. Rheumatol. 20:1993;1176-1183.
6. Casper H.H., McMahon T.L., Paulson G.D. J. Assoc. Off. Anal. Chem. 68:1985;772-775.
7. Okuno I., Meeker D.L., Felton R.R. J. Assoc. Off. Anal. Chem. 65:1982;1102-1105.
8. Kimble B.A., Mishalanie E.A. J. Chromatogr. 634:1993;289-296.
9. Allender W.J. J. Anal. Toxicol. 14:1990;45-49.
10. Burke D.G., Lew D.K.T., Cominos X. J. Assoc. Off. Anal. Chem. 72:1989;503-507.
11. Okuna I., Meeker D.L. J. Assoc. Off. Anal. Chem. 63:1980;49-55.
12. Vartaiainen T., Kauranen P. Anal. Chim. Acta. 157:1984;91-97.
13. W. Dale Snyder, in: K.J. Hyver (Ed.), High Resolution Gas Chromatography, ch. 5, 1989, pp. 1-12.
14. Deans D. Chromatographia. 1:1968;19-22.
15. R.C. Murphy and K.L. Clay, in: W.E.M. Lands, W.L. Smith (Eds.), Methods in Enzymology, vol. 86, 1982, pp. 547-551.
16. Mak A.Y., Swinney D.C. J. Am. Chem. Soc. 114:1992;8309-8310.