A role for protein kinase C-δ in the regulation of ornithine decarboxylase expression by oxidative stress

Cancer Research

Volumn 60, Issue 16, 2000, Pages 4391-4396

  Otieno, M A ^a   Kensler, T W ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPHOSTIN; HYDROGEN PEROXIDE; LUCIFERASE; MESSENGER RNA; ORNITHINE DECARBOXYLASE INHIBITOR; OXIDIZING AGENT; PROTEIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; CANCER; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GROWTH REGULATION; NONHUMAN; OXIDATIVE STRESS; PLASMID; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ANIMALS; CALCIUM; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HYDROGEN PEROXIDE; ISOENZYMES; MICE; ORNITHINE DECARBOXYLASE; OXIDANTS; OXIDATIVE STRESS; PAPILLOMA; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PROTEIN KINASE C-DELTA; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034662601     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Histamine, polyamines, and cancer
2. Cell transformation, invasion, and angiogenesis: A regulatory role for ornithine decarboxylase and polyamines?
3. Polyamines
4. Ornithine decarboxylase activity is critical for cell transformation
5. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin
6. Polyamine metabolism and function
7. Regulation of mammalian ornithine decarboxylase
8. Interrelation between the charge isoforms of mammalian ornithine decarboxylase
9. Ornithine decarboxylase from mouse epidermis and epidermal papillomas: Differences in enzymatic properties and structure
10. Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney
11. Phosphorylation of ornithine decarboxylase at both serine and threonine residues in the ODC-overproducing, Abelson virus-transformed RAW264 cell line
12. Multisite phosphorylation of ornithine decarboxylase in transformed macrophages results in increased intracellular enzyme stability and catalytic efficiency
13. Involvement of protein kinase C in the transcriptional regulation of 12-O-tetradecanoylphorbol-13-acetate-inducible genes modulated by AP-1 or non-AP-1 transacting factors
14. Prooxidant states and tumor promotion
15. Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors
16. Protein kinase C and lipid signaling for sustained cellular responses
17. Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium
18. Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the ε and δ isoforms of protein kinase C
19. Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol
20. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC δ
21. Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate
22. Characterization of a protein kinase C-δ (PKC-δ) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-δ enzymatic activity
23. Immunolocalization of microsomal glutathione S-transferase in rat tissues
24. Isolation of cDNAs representing dithiolethione-responsive genes
25. Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene
26. Inducible genetic suppression of neuronal excitability
27. Construction of adenovirus vectors through cre-lox recombination
28. Adenovirus-mediated expression of a voltage-gated potassium channel in vitro (rat cardiac myocytes) and in vivo (rat liver). A novel strategy for modifying excitability
29. Quinone methide mediates in vitro induction of ornithine decarboxylase by the tumor promoter butylated hydroxytoluene hydroperoxide
30. 2
31. Ornithine decarboxylase antizyme: A novel type of regulatory protein
32. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin
33. Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: Implications for cellular survival and tumor promotion
34. 2. Role in cell survival following oxidant injury
35. The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells
36. Three distinct mechanisms for translocation and activation of the δ subspecies of protein kinase C
37. 2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain
38. Expression of an ATP binding mutant of PKC-δ inhibits Sis-induced transformation of NIH3T3 cells
39. Tumor promotion by depleting cells of protein kinase C δ
40. Src promotes PKCδ degradation
41. Transgenic mice overexpressing protein kinase Cδ in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
42. Protein kinase Cδ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
43. Differential localization of protein kinase C δ by phorbol esters and related compounds using a fusion protein with green fluorescent protein