Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium aches-primed IFN-γ-deficient mice by a concomitant reduction of TNF-α, IL-12, and IL-18 production

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 1049-1055

  Tsuji, Hirokazu ^a   Mukaida, Naofumi ^a,e   Harada, Akihisa ^a,d,e   Kaneko, Shuichi ^a   Matsushita, Eiki ^a   Nakanuma, Yasuni ^a   Tsutsui, Hiroko ^b   Okamura, Haruki ^b   Nakanishi, Kenji ^b   Tagawa, Yoh Ichi ^c   Iwakura, Yoichiro ^c   Kobayashi, Ken Ichi ^a   Matsushima, Kouji ^d,e  

^a KANAZAWA UNIVERSITY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; HOST RESISTANCE; INFECTION RESISTANCE; INFLAMMATORY INFILTRATE; INTERFERON PRODUCTION; KNOCKOUT GENE; LIVER GRANULOMA; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES;

ACUTE DISEASE; ALANINE TRANSAMINASE; ANIMALS; DISEASE MODELS, ANIMAL; HEPATITIS, ANIMAL; IMMUNE SERA; INJECTIONS, INTRAPERITONEAL; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; LIPOPOLYSACCHARIDES; LIVER; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PROPIONIBACTERIUM ACNES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033556254     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Kunkel, S. L., and D. G. Remick, eds. 1992. Cytokines in Health and Disease. Marcel Dekker Inc., New York.
2. Dienes, H. P., G. Hess, M. Woorsdorfer, S. Rossol, H. Gallati, G. Ramadori, and K. H. Meyer zum Buschenfelde. 1991. Ultrastructural localization of interferon-producing cells in the livers of patients with chronic hepatitis B. Hepatology 13:321.
3. Takehara, T., N. Hayashi, K. Katayama, A. Kasahara, H. Fusamoto, and T. Kamada. 1992. Hepatitis B core antigen-specific interferon γ production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B. Scand. J. Gastroenterol. 27:727.
4. Iwata, K., T. Wakita, A. Okumura, K. Yoshioka, M. Takayanagi, J. R. Wands, and S. Kakumu. 1995. Interferon γ production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection. Hepatology 22:1057.
5. Smith, A. L., S. W. Barthold, M. S. de Souza, and K. Bottomly. 1991. The role of γ interferon in infection of susceptible mice with murine coronavirus, MHV-JHM. Arċh. Virol. 121:89.
6. Kusters, S., F. Gantner, G. Kunstle, and G. Tiegs. 1996. Interferon γ plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111:462.
7. -/- mice: role for IFN-γ in activating apoptosis of hepatocytes. J. Immunol. 159:1418.
8. Ferluga, J., and A. C. Allison. 1978. Role of mononuclear infiltrating cells in pathogenesis of hepatitis. Lancet 2:610.
9. Ulich, T. R., K. Z. Guo, B. Irwin, D. G. Remick, and G. N. Davatelis. 1990. Endotoxin-induced cytokine gene expression in vivo: Regulation of tumor necrosis factor and interleukin-1 α/β expression and suppression. Am. J. Pathol. 137:1173.
10. Nagakawa, J., I. Hishinuma, K. Hirota, K. Miyamoto, T. Yamanaka, K. Tsukidate, K. Katayama, and I. Yamatsu. 1990. Involvement of tumor necrosis factor-α in the pathogenesis of activated macrophage-mediated hepatitis in mice. Gastroenterology 99:758.
11. Fujioka, N., N. Mukaida, A. Harada, M. Akiyama, T. Kasahara, K. Kuno, A. Ooi, M. Mai, and K. Matsushima. 1995. Preparation of specific antibodies against murine IL-1ra and the establishment of IL-1ra as an endogenous regulator of bacteria-induced fulminant hepatitis in mice. J. Leukocyte Biol. 58:90.
12. Ikeda, N., N. Mukaida, S. Kaneko, N. Fujioka, S. Su, H. Nariuchi, M. Unoura, K. Harada, Y. Nakanuma, K. Kobayashi, et al. 1995. Prevention of endotoxin-induced acute lethality in Propionibacterium acnes-primed rabbits by an antibody to leukocyte integrin β2 with concomitant reduction of cytokine production. Infect. Immun. 63:4812.
13. Tsuji, H., A. Harada, N. Mukaida, Y. Nakanuma, H. Bluethmann, S. Kaneko, K. Yamakawa, S. Nakamura, K. Kobayashi, and K. Matsushima. 1997. Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. Infect. Immun. 65:1892.
14. Katschinski, T., C. Galanos, A. Coumbos, and M. A. Freudenberg. 1992. γ interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. Infect. Immun. 60:1994.
15. Smith, S. R., A. Calzetta, J. Bankowski, L. Kenworthy Bott, and C. Terminelli. 1993. Lipopolysaccharide-induced cytokine production and mortality in mice treated with Corynebacterium parvum. J. Leukocyte. Biol. 54:23.
16. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Andersson, G. J. Gleich, and J. E. Silver. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
17. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
18. Tanaka, Y., A. Takahashi, K. Watanabe, K. Takayama, T. Yahata, S. Habu, and T. Nishimura. 1996. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int. Immunol. 8:569.
19. Farrar, M. A., and R. D. Schreiber. 1993. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11:571.
20. Dighe, A. S., E. A. Bach, A. C. Greenlund, and R. D. Schreiber. 1997. The molecular basis of interferon-γ action. In Growth Factors and Cytokines in Health and Disease, Vol. 2B. D. LeRoith and C. Bondy, eds. JAI Press, Greenwich, CT, pp. 521-556.
21. Rossol, S., R. Voth, S. Brunner, W. E. Muller, M. Buttner, H. Gallati, K. H. Meyer zum Buschenfelde, and G. Hess. 1990. Corynebacterium parvum (Propionibacterium acnes): an inducer of tumor necrosis factor-α in human peripheral blood mononuclear cells and monocytes in vitro. Eur. J. Immunol. 20: 1761.
22. Tanaka, Y., K. Kobayashi, A. Takahashi, I. Arai, S. Higuchi, S. Otomo, S. Habu, and T. Nishimura. 1993. Inhibition of inflammatory liver injury by a monoclonal antibody against lymphocyte function-associated antigen-1. J. Immunol. 151:5088.
23. Anonymous. 1991. Granulomas and cytokines. Lancet 337:1067.
24. Chensue, S. W., K. S. Warmington, J. H. Ruth, P. Lincoln, and S. L. Kunkel. 1995. Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation: local and regional participation of IFN-γ, IL-10, and TNF. J. Immunol. 154:5969.
25. Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses Th2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
26. Taylor, A. P., and H. W. Murray. 1997. Intracellular antimicrobial activity in the absence of interferon-γ: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice. J. Exp. Med. 185:1231.
27. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 178:2243.
28. Dai, W. J., W. Bartens, G. Kohler, M. Hufnagel, M. Kopf, and F. Brombacher 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-γ receptor-deficient mice. J. Immunol. 158:5297.
29. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
30. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
31. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
32. Stern, A. S., J. Magram, and D. H. Presky. 1996. Interleukin-12: an integral cytokine in the immune response. Life Sci. 58:639.
33. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147.
34. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
35. Chensue, S. W., J. H. Ruth, K. Warmington, P. Lincoln, and S. L. Kunkel. 1995. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J. Immunol. 155:3546.
36. Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 179:1551.
37. Sanchez Bueno, A., V. Verkhusha, Y. Tanaka, O. Takikawa, and R. Yoshida. 1996. Interferon-γ-dependent expression of inducible nitric oxide synthase, interleukin-12, and interferon-γ-inducing factor in macrophages elicited by allografted tumor cells. Biochem. Biophys. Res. Commun. 224:555.
38. Flesch, I. E., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. Kaufmann. 1995. Early interleukin 12 produclion by macrophages in response to mycobactcrial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615.
39. Schijns, V. E., C. M. Wierda, M. van Hoeij, and M. C. Horzinek. 1996. Exacerbated viral hepatitis in IFN-γ receptor-deficient mice is not suppressed by IL-12. J. Immunol. 157:815.
40. Scharton-Kersten, T., T. A. Wynn, E. Y. Denkers, S. Bala, E. G. Grunvald, S. Hieny, R. T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045.
41. Heinzel, F. P., R. M. Rerko, F. Ahmed, and A. M. Hujer. 1996. IFN-γ-independent production of IL-12 during murine endotoxemia. J. Immunol. 157:4521.
42. Tsutsui, H., K. Matsui, N. Kawada, Y. Hyodo, N. Hayashi, H. Okamura, K. Higashino, and K. Nakanishi. 1997. IL-18 accounts for both TNF-α- and Fas ligand-mediated hepatoloxic pathways in endotoxin-induced liver injury in mice. J. Immunol. 159:3961.
43. Gu, Y., K. Kuida, H. Tsutsui, G. Ku, K. Hsiao, M. A. Fleming, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, et al. 1997. Activation of interferon-γ-inducing factor mediated by interleukin-1 β-converting enzyme. Science 275: 206.
44. Ghayur, T., S. Banerjee, M. Hugunin, D. Butler, L. Herzog, A. Carter, L. Quintal, L. Sekut, R. Talanian, M. Paskind, et al. 1997. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386:619.