Significant evidence for linkage disequilibrium over a 5-cM region among Afrikaners

Genomics

Volumn 66, Issue 1, 2000, Pages 87-92

  Gordon, Derek ^a   Simonic, Ingrid ^b   Ott, Jurg ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME 2; DNA DETERMINATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; HUMAN; PRIORITY JOURNAL; SOUTH AFRICA;

EID: 0034657998     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6190     Document Type: Article

References (32)

1. Broman K. W., Murray J. C., Sheffield V. C., White R. L., Weber J. L. Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am. J. Hum. Genet. 63:1998;861-869.
2. Crouau-Roy B., Service S., Slatkin M., Freimer N. A fine scale comparison of the human and chimpanzee genomes: Linkage, linkage disequilibrium and sequence analysis. Hum. Mol. Genet. 5:1996;1131-1137.
3. Freimer N. B., Service S. K., Slatkin M. Expanding on population studies. Nat. Genet. 17:1997;371-373.
4. Groenewald J. Z., Liebenberg J., Groenewald I. M., Warnich L. Linkage disequilibrium analysis in a recently founded population: Evaluation of the variegate porphyria founder in South African Afrikaners. Am. J. Hum. Genet. 62:1998;1254-1258.
5. Guo S. W. Linkage disequilibrium measures for fine-scale mapping: A comparison. Hum. Hered. 47:1997;301-314.
6. Guo S. W., Thompson E. A. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics. 48:1992;361-372.
7. Jenkins T. Medical genetics in South Africa. J. Med. Genet. 27:1990;760-779.
8. Jenkins T. The South African malady. Nat. Genet. 13:1996;7-9.
9. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat. Genet. 22:1999;139-144.
10. Laan M., Pääbo S. Demographic history and linkage disequilibrium in human populations. Nat. Genet. 17:1997;435-438.
11. Lazzeroni, L. C, and, Lange, K. 1995, Markov Chains for Monte Carlo Tests of Genetic Equilibrium in Multidimensional Contingency Tables, Technical Report No. 178, Division of Biostatistics, Stanford University.
12. Lewontin R. C. The interaction of selection and linkage. I. General considerations: Heterotic models. Genetics. 49:1964;49-67.
13. Maiste P. J. Comparison of Statistical Tests for Independence at Genetic Loci with Many Alleles. 1993;North Carolina State UniversityDepartment of Statistics.
14. Maiste P. J., Weir B. S. A comparison of tests for independence in the FBI RFLP data bases. Genetica. 96:1995;125-138.
15. Meissner P. N., Dailey T. A., Hift R. J., Ziman M., Corrigall A. V., Roberts A. G., Meissner D. M., Kirsch R. E., Dailey H. A. A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria. Nat. Genet. 13:1996;95-97.
16. Morton N. E., Wu D. Alternative bioassays of kinship between loci. Am. J. Hum. Genet. 42:1988;173-177.
17. Ott J. Analysis of Human Genetic Linkage. 1999;Johns Hopkins Univ. Press, Baltimore.
18. Peterson A. C., Di Rienzo A., Lehesjoki A. E., de la Chapelle A., Slatkin M., Freimer N. B. The distribution of linkage disequilibrium over anonymous genome regions. Hum. Mol. Genet. 4:1995;887-894.
19. Schneider, S, Kueffer, J-M, Roessli, D, and, Excoffier, L. 1997, Arlequin Version 1.1: A Software for Population Genetic Data Analysis, Genetics and Biometry Laboratory, University of Geneva, Switzerland.
20. Simonic I., Gericke G. S., Ott J., Weber J. L. Identification of genetic markers associated with Gilles de la Tourette syndrome in an Afrikaner population. Am. J. Hum. Genet. 63:1998;839-846.
21. Slatkin M. Linkage disequilibrium in growing and stable populations. Genetics. 137:1994;331-336.
22. Slatkin M., Excoffier L. Testing for linkage disequilibrium in genotypic data using the EM algorithm. Heredity. 76:1996;377-383.
23. Starfield M., Hennies H. C., Jung M., Jenkins T., Wienker T., Hull P., Spurdle A., Kuster W., Ramsay M., Reis A. Localization of the gene causing keratolytic winter erythema to chromosome 8p22-p23, and evidence for a founder effect in South African Afrikaans-speakers. Am. J. Hum. Genet. 61:1997;370-378.
24. Terwilliger J. D., Ott J. Handbook of Human Genetic Linkage. 1994;Johns Hopkins Univ. Press, Baltimore.
25. Terwilliger J. D., Zollner S., Laan M., Paabo S. Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion. Hum. Hered. 48:1998;138-154.
26. Torrington M., Botha J. L., Pilcher G. J., Baker S. G. Association between familial hypercholesterolaemia and church affiliation. S. A. Med. J. 65:1984;762-767.
27. Warnich L., Meissner P. N., Hift R. J., Louw J. H., van Heerden C. J., Retief A. E. Mapping of variegate porphyria (VP) gene: Contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32. Hum. Genet. 97:1996;690-692.
28. Weir B. S. Disequilibrium on chromosome 21 in some Utah families. Cytogenet. Cell. Genet. 59:1992;128-129.
29. Weir B. S., Cockerham C. C. Testing hypotheses about linkage disequilibrium with multiple alleles. Genetics. 88:1978;633-642.
30. Xie X., Ott J. Testing linkage disequilibrium between a disease gene and marker loci. Am. J. Hum. Genet. 53:1993.
31. Zaykin D., Zhivotovsky L., Weir B. S. Exact tests for association between alleles at arbitrary numbers of loci. Genetica. 96:1995;169-178.
32. Zouros E., Golding G. B., Mackay T. F. C. The effect of combining alleles into electrophoretic classes on detecting linkage disequilibrium. Genetics. 85:1977;543-556.