A pharmacokinetic model of anaerobic in vitro carbon tetrachloride metabolism

Chemico-Biological Interactions

Volumn 101, Issue 1, 1996, Pages 13-31

  Andersen, Nancy J ^a   Waller, Chris L ^a   Adamovic, Joseph B ^a   Thompson, Daniel J ^b   Allis, John W ^a   Andersen, Melvin E ^a,c   Simmons, Jane Ellen ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b ALION SCIENCE AND TECHNOLOGY   (United States)

^c ICF Kaiser   (United States)

Author keywords

Anaerobic; Carbon tetrachloride; Cytochrome P450; In vitro; Metabolism; Pharmacokinetic model

Indexed keywords

CARBON TETRACHLORIDE; CHLOROFORM; CYTOCHROME P450 INHIBITOR; DIALLYLSULFONE; UNCLASSIFIED DRUG;

ANAEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEEDING; FOOD DEPRIVATION; GAS CHROMATOGRAPHY; LIVER MICROSOME; MALE; METABOLIC RATE; MODEL; NONHUMAN; PHARMACOKINETICS; RAT; TOXICOKINETICS;

ANIMALIA;

EID: 0029973640     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(96)03708-8     Document Type: Article

References (41)

1. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Carbon Tetrachloride, US Department of Health and Human Services, Public Health Service, 1994.
2. H.J. Kim, J.V. Bruckner, C.E. Dallas and J.M. Gallo, Effect of dosing vehicles on the pharmacokinetics of orally administered carbon tetrachloride in rats, Toxicol. Appl. Pharmacol., 102 (1990) 50-60.
3. J.S.L. Fowler, Carbon tetrachloride metabolism in the rabbit, Br. J. Pharmacol., 37 (1969) 733-737.
4. D.J. Paustenbach, G.P. Carlson, J.E. Christian and G.S. Born, A comparative study of the phar-macokinetics of carbon tetrachloride in the rat following repeated inhalation exposures of 8 and 11.5 h/day, Fundam. Appl. Toxicol., 6 (1986) 484-487.
5. D.J. Paustenbach, J.E. Christian, G.P. Carlson and G.S. Born, The effect of an 11.5-h/day exposure schedule on the distribution and toxicity of inhaled carbon tetrachloride in the rat, Fundam. Appl. Toxicol., 6 (1986) 472-483.
6. M.L. Gargas, M.E. Andersen and H.J. Clewell III, A physiologically based simulation approach for determining metabolic constants from gas uptake data, Toxicol. Appl. Pharmacol., 86 (1986) 341-352.
7. N. Uemitsu, Inhalation pharmacokinetics of carbon tetrachloride in rats based on arterial blood: inhaled air concentration ratios, Toxicol. Appl. Pharmacol., 83 (1986) 20-29.
8. M.E. Andersen, Tissue dosimetry in risk assessment, or What's the problem here anyway?, in: Pharmacokinetics in Risk Assessment. Vol. 8 Drinking Water and Health, National Academey Press, Washington, DC, 1987, pp. 8-26.
9. I.G. Sipes, G. Krishna and Gillette J.R., Bioactivation of carbon tetrachloride, chloroform, and bromodichloromethane: role of cytochrome P-450, Life Sci., 20 (1977) 1541-1548.
10. T.C. Butler, Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents, J. Pharmacol. Exp. Ther., 134 (1961) 311-319.
11. R.O. Recknagel, E.A. Glende, J.A. Dolak and R.L. Waller, Mechanisms of carbon tetrachloride toxicity, Pharmacol. Ther., 43 (1989) 139-154.
12. F.P. Guengerich, D.H. Kim and M. Iwasaki, Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects, Chem. Res. Toxicol., 5 (1991) 168-179.
13. J.F. Brady, M.H. Nang, J.Y. Hong, F. Xiao, Y. Li, H.J.S. Yoo, S.M. Ning, M.J. Lee, J.M. Fukoto, J.M. Gapac and C.S. Yang, Modulation of rat hepatic microsomal monoxygenase enzymes and cytotoxicity by diallyl sulfide, Toxicol. Appl. Pharmacol., 108 (1991) 342-354.
14. J.F. Brady, F. Xiao, M.H. Wang, Y. Li, S.M. Ning, J.M. Gapac and C.S. Yang, Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes and hepatotoxicity in rats, Toxicol. Appl. Pharmacol., 108 (1991) 366-373.
15. J.E.A. Leakey, R. Hume and B. Burchell, Development of multiple activities of UDP-Glucoronyltransferase in human liver, Biochem. J., 243 (1987) 859-861.
16. O.H. Lowry, N.J. Rosenbrough, A.L. Farr and R.J. Randall, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
17. J. Drozd, Z. Vodakova and P. Koupil, Systematic errors with the use of internal standard calibration in gas chromatographic headspace analysis, J. Chromatogr., 518 (1990) 1-8.
18. SAS Institute, Inc. SAS/STAT User's Guide, PROC GLM, version 6, 4th ed., Vol. 2. Cary, N.C.: SAS Institute, Inc, 1989.
19. M. Gargas, R.J. Burgess, D.E. Voisard, G.H. Cason and M.E. Andersen, Partition coefficients of low-molecular-weight volatile chemical in various liquids and tissues, Toxicol. Appl. Pharmacol., 98 (1989) 87-99.
20. I. Johansson and M. Ingelman-Sundberg, Carbon tetrachloride induced lipid peroxidation dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P-450, FEBS Lett., 183 (1985) 265-269.
21. T. Noguchi, K.L. Fong, E.K. Lai, S.S. Alexander, M.M. King, L. Olson, J.L. Poyer and P.B. McCay, Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical, Biochem. Pharmacol., 31 (1982) 615-624.
22. 4-treated rats. Relationship to cytochrome P-450 content, Biochem. Pharmacol., 31 (1982) 609-614.
23. P.T. Liu, P.A. Kentish, A.M. Symons and D.V. Parke, The effects of ether anesthesia on oxidative stress in rats - dose response, Toxicology, 80 (1993) 37-49.
24. D.J. Paustenbach, H.J. Clewell and M.L. Gargas, A physiologically based pharmacokinetic model for inhaled carbon tetrachloride, Toxicol. Appl. Pharmacol., 96 (1988) 192-211
25. M.V. Evans, W.D. Crank, H.-M. Yang and J.E. Simmons, Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats, Toxicol. Appl. Pharmacol., 128 (1994) 36-44.
26. 14C) carbon tetrachloride to exhaled, excreted and bound metabolites. Dose response, time-course and pharmacokinetics, Biochem. Pharmacol., 33 (1984) 3363-3374.
27. T. Nakajima, E. Elovaara, T. Okino, H.V. Gelboin, M. Klockars, V. Riihimaki, T. Aoyama and H. Vainino, Different contribution of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat, Toxicol. Appl. Pharmacol., 133 (1995) 215-222.
28. R.N. Harris and M.W. Anders, Effect of fasting, diethyl maleate and alcohols on carbon tetrachloride-induced hepatotoxicity, Toxicol. Appl. Pharmacol., 56 (1980) 192-198.
29. R.J. Jaeger, R.B. Conolly and S.D. Murphy, Short-term inhalation toxicity of halogenated hydrocarbons, Arch. Environ. Health, 30 (1974) 26-31.
30. 4 activation and of lipid peroxidation, Toxicol. Appl. Pharmacol., 34 (1975) 102-114.
31. A. Sato and T. Nakajima, Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study, Xenobiotica, 15(1) (1985) 67-75.
32. O. Strubelt, E. Dost-Kempf, C.P. Siegers, M. Younes, M. Volpel, U. Preuss and J. Dreckmann, The influence of fasting on the susceptibility of mice to hepatotoxic injury, Toxicol. Appl. Pharmacol., 60 (1981) 66-88
33. T. Nakajima and A. Sato, Enhanced activity of liver drug-metabolizing enzymes for aromatic and chlorinated hydrocarbons following food deprivation, Toxicol. Appl. Pharmacol., 50 (1979) 549-556.
34. B.L. Brown, J.W. Allis, J.E. Simmons and D.E. House, Fasting for less than 24 h induces cytochrome P450 2E1 and 2B1/2 activities in rats, Toxicol. Lett., 81 (1995) 39-44.
35. J. Hong, J. Pan, H.V. Gelboin and C.S. Yang, The induction of a specific form of Cytochrome P-450 (P-450) by fasting, Biochem. Biophys. Res. Commun., 142 (1987) 1077-1083.
36. I. Johansson, G. Ekstrom, B. Sholte, D. Puzycki, H. Jornvall and M. Ingleman-Sundberg, Ethanol-, fasting-, and acetone-inducible cytochrome P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies, Biochemistry, 27 (1988) 1925-1934.
37. R. Pentz and O. Strubelt, Fasting increases the concentration of carbon tetrachloride and of its metabolite chloroform in the liver of mice, Toxicol. Lett., 15 (1983) 231-234.
38. K. Krishnan and M.E. Andersen, Physiologically-Based Pharmacokinetic Modeling in Toxicology, in: A. Wallace Hayes (Ed.), Principles and Methods of Toxicology, 3rd edn. Raven Press, Ltd. New York, 1994.
39. R.J. Smialowicz, J.E. Simmons, R.W. Luebke and J.W. Allis, Immunotoxicologic assessment of subacute exposure of rats to carbon tetrachloride with comparison to hepatotoxicity and nephrotoxicity, Fundam. Appl. Toxicol., 17 (1991) 186-196.
40. International Life Sciences Institute (ILSI), Physiological Parameter Values for PB-PK Models. Risk Science Institute, U.S. Environmental Protection Agency. Office of Health and Environmental Assessment, 1994.
41. M.L. Gargas, H.J. Clewell and M.E. Andersen, Gas uptake inhalation techniques and the rates of metabolism of chloromethanes, chloroethanes, and chloroethylenes in the rat, Inhal. Toxicol., 2 (1990) 295-319.