Carbon tetrachloride: Genetic effects and other modes of action

Mutation Research - Reviews in Genetic Toxicology

Volumn 366, Issue 3, 1996, Pages 181-195

  McGregor, Douglas ^a   Lang, Matti ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450;

CARCINOGENICITY; GENOTOXICITY; HUMAN; LIVER TOXICITY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; RAT; REVIEW; XENOBIOTIC METABOLISM;

EID: 0030604292     PISSN: 01651110     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1110(96)00027-9     Document Type: Article

References (113)

1. [1] Environmental Protection Agency (1984) Health Assessment Document for Carbon Tetrachloride, EPA-600/8-82-001F, Cincinnati, OH.
2. [2] IARC (1995) Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 63, Dry Cleaning, Some Industrial Solvents and Other Industrial Chemicals, International Agency for Research on Cancer, Lyon, p. 34.
3. [3] United States International Trade Commission (1993) Synthetic Organic Chemicals: United States Production and Sales, 1991. USITC Publication 2607. Washington DC, pp. 15-9.
4. [4] Weast, R.C. (Ed.) (1985) Handbook of Chemistry and Physics, 66th edn., CRC Press, Cleveland, OH, p. C-350.
5. 2 hydrocarbons in the marine environment, Proc. Roy. Soc. Lond. B., 189, 305-332.
6. [6] Neely, W.B., D.R. Branson and G.E. Blau (1974) Partition coefficient to measure bioconcentration potential of organic chemicals in fish, Environ. Sci. Technol., 8, 1113-1115.
7. [7] Rechnagel, R.O., E.A. Glende, Jr., J.A. Dolak and R.L. Waller (1989) Mechanisms of carbon tetrachloride toxicity, Pharmacol. Ther., 43, 139-154.
8. [8] Lamson, P.D. And R. Wing (1926) Early cirrhosis of the liver produced in dogs by carbon tetrachloride, J. Pharmacol. Exp. Ther., 29, 191-202.
9. 4 an adequate model of human cirrhosis? Hepatology, 3, 112-120.
10. [10] Brauer, M., R.A. Towner, I. Renaud, E.G. Janzen and D.L. Foxall (1989) In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage, Magn. Reson. Med., 9, 229-239.
11. 4-induced hepatotoxicity in rats, Can. J. Phys. Pharm., 72, 441-446.
12. 4-induced rat liver injury detected by proton magnetic resonance imaging (MRI) in vivo and electron microscopy (EM), Free Radical Res. Commun., 9, 325-336.
13. [13] Sipes, I.G., A.E. El Sisi, W.W. Simm, S.A. Mobley and D.L. Earnest (1989) Role of reactive oxygen species secreted by activated Kupffer cells in the potentiation of carbon tetrachloride hepatotoxicity by hypervitaminosis A, in: E. Wisse, D.L. Knook and R.S. McCuskey (Eds.), Cells of the Hepatic Sinusoid, Vol. 2, Kupffer Cell Foundation, Rijswijik, pp. 376-379.
14. [14] Edwards, M.J., B.J. Keller, F.C. Kaufman and R.G. Thurman (1993) The involvement of Kupffer cells in carbon tetrachloride toxicity, Toxicol. Appl. Pharmacol., 119, 275-279.
15. [15] El Sisi, A.E.D., D.L. Earnest and J.G. Sipes (1993) Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species, Toxicol. Appl. Pharmacol., 119, 295-301.
16. 4-induced liver injury, in: E. Wisse, D.D. Knook and K. Decker (Eds.), Cells of the Hepatic Sinusoid, Vol. 2, Kupffer Cell Foundation, Rijswijk, pp. 281-283.
17. [17] Jaeschke, H., C.W. Smith and A. Farhood (1991) The pathophysiological role of Kupffer cells and neutrophils in hepatic ischemia reperfusion injury in vivo, in: E. Wisse, D.L. Knook and R.S. McCuskey (Eds.), Cells of the Hepatic Sinusoid, Vol. 3, Kupffer Cell Foundation, Rijswijk, Netherlands, pp. 367-370.
18. [18] MacPhee, P.J. and P.A. Keown (1989) Mechanisms of hepatic injury in viral (MHV-3) hepatitis: role of macrophage production of excited oxygen radicals, in: E. Wisse, D.L. Knook and K. Decker (Eds.), Cells of the Hepatic Sinusoid, Vol. 2, Kupffer Cell Foundation, Rijswijk, pp. 363-364.
19. [19] Spitzer, J.A., Z. Spolaries, A.P. Bautista, A. Schuler and C.H. Long (1991) Metabolic and functional activation of hepatic nonparenchymal cells following endotoxin or TNF administration or latex phagocytosis, in: E. Wisse, D.L. Knook and R.S. McCuskey (Eds.), Cells of the Hepatic Sinusoid, Vol. 3, Kupffer Cell Foundation, Rijswijk, pp. 68-72.
20. [20] Shiratori, Y., T. Kawase, S. Shiina, K. Okano, T. Sugimoto, H. Teraoka, S. Matano, K. Matsumoto and K. Kamii (1988) Modulation of hepatotoxicity by macrophages in the liver, Hepatology, 8, 815-821.
21. [21] Shiratori, Y., H. Takada, K. Hai, H. Kiriyama, K. Matsumoto, K. Kamii and M. Tanaka (1991) Generation of chemotactic factor by hepatocytes exposed to ethanol. A possible mechanism of Kupffer cell and neutrophil accumulation in the rat after ethanol feeding, in: E. Wisse, D.L. Knook and R.S. McCuskey (Eds.), Cells of the Hepatic Sinusoid, Vol. 3, Kupffer Cell Foundation, Rijswijk, pp. 476-479.
22. [22] Przybocki, J.M., K.R. Reuhl, R.G. Thurman and F.C. Kauffman (1992) Involvement of nonparenchymal cells in the oxygen-dependent hepatic injury by allyl alcohol, Toxicol. Appl. Pharmacol., 115, 57-63.
23. [23] Gunawardhana, L., S.A. Mobley and I.G. Sipes (1993) Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavanger of superoxide anions and an inhibitor of Kupffer cells, Toxicol. Appl. Pharmacol., 119, 205-213.
24. [24] Hooser, S.B., R.J. Rosengren, D.A. Hill, S.A. Mobley and I.G. Sipes (1994). Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents, Environ. Health Perspect., 102, 39-43.
25. [25] Lans, M., J. de Gerlache, H.S. Taper, V. Préat and M.B. Roberfroid (1983) Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis, Carcinogenesis, 4, 141-144.
26. [26] Mirsalis, J.C., C.K. Tyson, E.N. Loh, K.L. Steinmetz, J.P. Bakke, C.M. Hamilton, D.K. Spak and J.W. Spalding (1985) Induction of hepatic cell proliferation and unscheduled DNA synthesis in mouse hepatocytes following in vivo treatment, Carcinogenesis, 6, 1521-1524.
27. [27] Doolittle, D.J., G. Müller and H.E. Scribner (1987) Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride, J. Toxicol. Environ. Health, 22, 63-78.
28. [28] Puri, E.C. and D. Müller (1989) Testing of hydralazine in in vivo-in vitro hepatocyte assays for UDS and stimulation of replicative DNA synthesis, Mutation Res., 218, 13-19.
29. [29] Asakura, S., S. Sawada, H. Daimon, T. Fukuda, K. Ogura, K. Yamatsu and C. Furihata (1994) Effects of dietary restriction on induction of unscheduled DNA synthesis (UDS) and replicative synthesis (RDS) in rat liver, Mutation Res., 322, 257-264.
30. [30] IARC (1979) Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 20, Some Halogenated Hydrocarbons. International Agency for Research on Cancer, Lyon, pp. 371-399.
31. 4 nel ratto, Arch. De Vecchi Anat. pat., 39, 302-356.
32. [32] National Cancer Institute (1976a) Report on the Carcinogenesis Bioassay of Chloroform. Carcinogenesis Program, Division of Cancer Cause and Prevention, Bethesda, MD.
33. [33] National Cancer Institute (1976b) Carcinogenesis Bioassay of Trichloroethylene (CAS No. 79-01-6) NCI TR 2, DHEW Publ. No. 76-802, Bethesda, MD.
34. [34] National Cancer Institute (1977) Bioassay of 1,1,1-Trichloroethane for Possible Carcinogenicity (CAS No. 71-55-6) NCI TR 3, DHEW (NIH) Publ. No. 77-803, Bethesda, MD.
35. [35] Della Porta, G., B. Terracini and P. Shubik (1961) Induction with carbon tetrachloride of liver-cell carcinomas in hamsters, J. Natl. Cancer Inst., 26, 855-863.
36. [36] Reuber, M.D. And E.L. Glover (1970) Cirrhosis and carcinoma of the liver in male rats given subcutaneous carbon tetrachloride, J. Natl. Cancer Inst., 44, 419-427.
37. [37] Zalatnai, A., I. Sáosi, A. Rot and K. Lapsis (1991) Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats, Cancer Lett., 57, 67-73.
38. [38] Zalantnai, A. and K. Lapis (1994) Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model, Exp. Toxicol. Pathol., 46, 215-222.
39. [39] Cho, K.-J., J.J. Jang (1993) Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats, Cancer Lett., 70, 33-39.
40. [40] Sone, H., K. Wakabayashi, H. Kushida, T. Sugimura and M. Nagao (1992) Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride, Carcinogenesis, 13, 793-797.
41. 4 reactive metabolites and liver DNA or nuclear protein fractions, Carcinogenesis, 10, 289-294.
42. [42] Wagner III, V.O. and R.D. Blevins (1993) Chemically-induced histone modification as a predictor of carcinogenicity, Arch. Environ. Contam. Toxicol. 25, 260-266.
43. [43] Wang, M.Y. and J.G. Liehr (1995) Lipid hydroperoxide-induced endogenous DNA adducts in hamsters: possible mechanism of lipid hydroperoxide-mediated carcinogenesis, Arch. Biochem. Biophys., 316, 38-46.
44. [44] Nath, R.G., D.H. Li and K. Randerath (1990) Acute and long-term effects of carbon tetrachloride on DNA modifications (I-compounds) in male mouse liver, Chem. Biol. Interact., 76, 343-357.
45. [45] Nakamura, S.I., Y. Oda, T. Shimada, I. Oki and K. Sugimoto (1987) SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals [published erratum appears in Mutation Res. 1988, 207, 213], Mutation Res. 192, 239-246.
46. [46] Brams, A., J.P. Buchet, M.C. Crutzen Fayt, C. De Meester, R. Lauwerys and A. Leonard (1987) A comparative study, with 40 chemicals, of the efficiency of the Salmonella assay and the SOS chromotest (kit procedure), Toxicol. Lett., 38, 123-133.
47. [47] Roldán-Arjona, T., M.D. Garcia-Pedrajas, F.L Luque-Romero, C. Hera and C. Pueyo (1991) An association between mutagenicity of the Ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons, Mutagenesis, 6, 199-205.
48. [48] Roldán-Arjona, T. and C. Pueyo (1993) Mutagenic and lethal effects of halogenated methanes in the Ara test of Salmonella typhimurium: quantitative relationship with chemical reactivity, Mutagenesis, 8, 127-131.
49. [49] Simmon, V.F., K. Kauhanen and R.G Tardiff (1977) Mutagenic activity of chemicals identified in drinking water, in: D. Scott, B.A. Bridges and F.H. Sobels (Eds.) Progress in Genetic Toxicology, Elsevier/North-Holland, Amsterdam, pp. 249-258.
50. [50] Zeiger, E., B. Anderson, S. Haworth, T. Lawlor and K. Mortelmans (1988) Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals, Environ. Mol. Mutagen. 11 Suppl. 12, 1-157.
51. [51] De Flora, S. (1981) Study of 106 organic and inorganic compounds in the Salmonella/microsome test, Carcinogenesis, 2, 283-298.
52. [52] Barber, E.D., W.H. Donish and K.R. Mueller (1981) A procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames Salmonella/microsome assay, Mutation Res., 90, 31-48.
53. [53] McCann, J., E. Choi, E. Yamasaki and B.N. Ames (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals, Proc. Natl. Acad. Sci., 72, 5135-5139.
54. [54] Uehleke, H., T. Werner, H. Greim and M. Kramer (1977) Metabolic activation of haloalkanes and tests in vitro for mutagenicity, Xenobiotica, 7, 393-400.
55. [55] Norpoth, K.A. Reisch and A. Heinecke (1980) Biostatistics of Ames-test data, in: K.H. Norpoth and R.C. Garner (Eds.), Short-Term Test Systems for Detecting Carcinogens. Springer-Verlag, New York, pp. 312-322.
56. [56] Callen, D.F., C.R. Wolf and R.M. Philpot (1980) Cytochrome P-450 mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in Saccharomyces cerevisiae, Mutation Res. 77, 55-63.
57. [57] Schiestl, R.H., R.D. Gietz, R.D. Mehta and P.J. Hastings (1989) Carcinogens induce intrachromosomal recombination in yeast, Carcinogenesis, 10, 1445-1455.
58. 2 cell cycle arrested yeast cells, Carcinogenesis, 16, 659-663.
59. [59] Whittaker, S.G., F.K. Zimmermann, B. Dicus, W.W. Piegorsch, S. Fogel and M.A. Resnick (1989) Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae - an interlaboratory study, Mutation Res., 224, 31-78.
60. 4 and lipoperoxide in Aspergillus nidulans, Mutation Res., 136, 109-114.
61. [61] Sina, J.F., C.L. Bean, G.R. Dysart, V.I. Taylor and M.O. Bradley (1983) Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential, Mutation Res., 113, 357-391.
62. [62] Dean, B.J. and G. Hodson-Walker (1979) An in vitro chromosome assay using cultured rat-liver cells, Mutation Res., 64, 329-337.
63. [63] Loveday, K.S., B.E. Anderson, M.A. Resnick and E. Zeiger (1990) Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals, Environ. Mol. Mutagenesis, 16, 272-303.
64. [64] Önfelt, A. (1987) Spindle disturbances in mammalian cells. III. Toxicity, c-mitosis and aneuploidy with 22 different compounds. Specific and unspecific mechanisms, Mutation Res., 182, 135-154.
65. [65] Coutino, R.R. (1979) Analysis of anaphase in cell culture: an adequate test system for the distinction between compounds which selectively alter the chromosome structure or the mitotic apparatus, Environ. Health Perspect., 31, 131-136.
66. [66] Amacher, D.E. and I. Zelljadt (1983) The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to Salmonella typhimurium, Carcinogenesis, 4, 291-295.
67. [67] Garry, V.F., R.L. Nelson, J. Griffith and M. Harkins (1990) Preparation for human study of pesticide applicators: sister chromatid exchanges and chromosomal aberrations in cultured human lymphocytes exposed to selected fumigants, Teratogen. Carcinogen. Mutagen., 10, 21-29.
68. [68] Braun, R. and J. Schöneich (1981) The influence of ethanol and carbon tetrachloride on the mutagenic effectivity of cyclophosphamide in the host-mediated assay with Salmonella typhimurium, Mutation Res., 31, 191-194.
69. [69] Bermudez, E., J.C. Mirsalis and H.C. Eales (1982) Detection of DNA damage in primary cultures of rat hepatocytes following in vivo and in vitro exposure to genotoxic agents, Environ. Mutagen., 4, 667-679.
70. [70] Schwarz, M., J. Hummel, K.E. Appel, R. Rickart and W. Kunz (1979) DNA damage induced in vivo evaluated with a non-radioactive alkaline elution technique, Cancer Lett., 6, 221-226.
71. [71] Barbin, A., J.C. Bereziat and H. Bartsch (1983) Evaluation of DNA damage by the alkaline elution technique in liver, kidneys and lungs of rats and hamsters treated with N-nitrosodialkylamines, Carcinogenesis, 4, 541-545.
72. [72] Brambilla, G., P. Carlo, R. Finollo, F.A. Bignone, A. Ledda and E. Cajelli (1983) Viscometric detection of liver DNA fragmentation in rats treated with minimal doses of chemical carcinogens, Cancer Res., 43, 202-209.
73. [73] Kitchen, K.T. and J.L. Brown (1989) Biochemical effects of three carcinogenic chlorinated methanes in rat liver Teratogen. Carcinogen. Mutagen., 9, 61-69.
74. [74] Craddock, V.M. and A.R. Henderson (1978) De novo and repair replication of DNA in liver of carcinogen-treated animals, Cancer Res., 38, 2135-2143.
75. [75] Mirsalis, J.C., C.K. Tyson and B.E. Butterworth (1982) Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay, Environ. Mutagen., 4, 553-562.
76. [76] Mirsalis, J.C. and B.E. Butterworth (1980) Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo-in vitro assay for potential carcinogens and mutagens, Carcinogenesis, 1, 621-625.
77. [77] Gans, J.H. and R. Korson (1984) Liver nuclear DNA synthesis in mice following carbon tetrachloride administration or partial hepatectomy, Proc. Soc. Exp. Biol. Med., 175, 237-242.
78. [78] Sawada, S., T. Yamanaka, K. Yamatsu, C. Furihata, and T. Matsushima (1991) Chromosome aberrations, micronuclei and sister-chromatid exchanges (SCEs) in rat liver induced in vivo by hepatocarcinogens including heterocyclic amines, Mutation Res., 251, 59-69.
79. [79] Lil'p, I.G. (1983) Instability of the chromosomes in 101/H and C57B1/6 mice during aging, Soviet Genet, 18, 1467-1472.
80. [80] Topham, J.C. (1980) Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens? Mutation Res., 74, 379-387.
81. [81] Ashby, J. and D. Paton (1993) The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures, Mutation Res., 286, 3-74.
82. [82] Varela-Moreiras, G., E. Alonso-Aperte, M. Gasso, R. Deulofeu, L. Alvarez, J. Caballera, J. Rodés and J.M. Mato (1995) Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment, Hepatology, 22, 1310-1315.
83. [83] Sanzgiri, U.Y., H.J. Kim, S. Muralidhara, C.E. Dallas and J.V. Bruckner (1995) Effect of route and pattern of exposure on the pharmacokinetics and acute hepatotoxicity of carbon tetrachloride, Toxicol. Appl. Pharmacol., 134, 148-154.
84. [84] Harris, R.N. and M.W. Anders (1981) 2-Propanol treatment induces selectively the metabolism of carbon tetrachloride to phosgene, Drug Metab. Dispos., 9, 551-556.
85. [85] Anders, M.W. and I. Jakobson (1985) Biotransformation of halogenated solvents, Scand. J. Work Environ. Health, 11 (Suppl. 1), 23-32.
86. [86] Slater, T.F. (1984) Free radical mechanisms in tissue injury, Biochem. J., 222, 1-15.
87. [87] Halliwell, B. and J. Gutteridge (1984) Oxygen toxicity, oxygen radicals, transition metals and disease, Biochem. J., 219, 1-14.
88. [88] Castro, G.D., M.I. Díaz-Gómez and J.A. Castro (1990) Biotransformation of carbon tetrachloride and lipid peroxidation promotion by liver nuclear preparations from different animal species, Cancer Lett., 53, 9-15.
89. 4 oxidation, J. Appl. Toxicol., 14, 453-455.
90. [90] Fanelli, S.L. and J.A. Castro (1993) Carbon tetrachloride promoted malonaldehyde formation in liver microsomal and nuclear preparations from Sprague Dawley or Osborne Mendel male rats, Res. Commun. Chem. Pathol. Pharmacol., 82, 233-236.
91. [91] Pohl, L.R., R.D. Schulick, R.J. Highet and J.W. George (1984) Reductive-oxygenation mechanism of metabolism of carbon tetrachloride to phosgene by cytochrome P-450, Mol. Pharmacol., 25, 318-321.
92. [92] Raucy, J.L., J.C. Kraner and J.M. Lasker (1993) Bioactivation of halogenated hydrocarbons by cytochrome P4502E1, Crit. Rev. Toxicol., 23, 1-20.
93. [93] Suarez, K.A., G.P. Carlson and G.C. Fuller (1975) Effect of phenobarbital or 3-methylcholanthrene pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver, Toxicol. Appl. Pharmacol., 34, 314-319.
94. [94] Lindstrom, T.D., M.W. Anders and H. Remmer (1978) Effect of phenobarbital and diethyl maleate on carbon tetrachloride toxicity in isolated rat hepatocytes, Exp. Mol. Pathol., 28, 48-57.
95. [95] Johansson, I. and M. Ingelman-Sundberg (1985) Carbon tetrachloride-induced lipid peroxidation dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P-450, FEBS Lett., 183, 265-269.
96. [96] Gadeholt, G. (1984) Ethanol-inducible cytochrome P-450 is more susceptible to in vitro carbon tetrachloride-mediated descruction than phenobarbital-inducible and β-naphtoflavone-inducible cytochromes P-450, Acta Pharmacol. et Toxicol., 55, 216-223.
97. [97] Pellinen, P., F. Stenbäck, A. Rautio, O. Pelkonen, M. Lang and M. Pasanen (1993) Response of mouse liver coumarin 7-hydroxlase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases, Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 435-443.
98. [98] Camus-Randon, A.-M., F. Raffalli, J.-C. Béréziat, D. McGregor and M.A. Lang (1996) Liver injury and expression of cytochromes P450: evidence that regulation of CYP2A5 is different from that of other xenobiotic metabolizing CYP enzymes, Toxicol. Appl. Pharmacol., 138, 140-148.
99. 4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding, Hepatology, 22, 1474-1481.
100. [100] Gruebele, A., K. Zawaski, D. Kaplan and R.F. Novak (1996) Cytochrome P4502E1-and cytochrome P4502B1/2B2-catalysed carbon tetrachloride metabolism. Effects on signal transduction as demonstrated by altered immediate-early (c-Fos and c-Jun) gene expression and nuclear AP-1 and NF-κ B transcription factor levels, Drug Metab. Disp., 24, 15-22.
101. [101] Koop, D.R., A. Chernosky and E.P. Brass (1991) Identification and induction of cytokine P450 2E1 in rat Kupffer cells, J. Pharmacol. Exp. Ther., 258, 1072-1076.
102. [102] Schreck, R., B. Meier, D.N. Männel, W. Dröge and P. Baeuerle (1992) dithiocarbamates as potent inhibitors of nuclear factor κ B activation in intact cells, J. Exp. Med., 175, 1181-1194.
103. [103] Czaja, M.J., J. Xu and E. Alt (1995) Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor, Gastroenterology, 108, 1849-1854.
104. [104] Brady, J.F., M.-H. Wang, J.-Y. Hong, F. Xiao, Y. Li, J.-S.H. Yoo, S.M. Ning, M.-J. Lee, J.M. Fukuto, J.M. Gapac and C.S. Yang (1991) Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide, Toxicol. Appl. Pharmacol., 108, 342-354.
105. [105] Yang, C.S., T.J. Smith and J.-Y. Hong (1994) Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations, Cancer Res. (Suppl.), 54, 1982s-1986s.
106. [106] Nakayama, T., M. Kaneko and M. Kodama (1986) Detection of DNA damage in cultured human fibroblasts induced by methyl linoleate hydroperoxide, Agric. Biol. Chem., 50, 261-262.
107. [107] Sevanian, A. and H. Peterson (1989) Induction of cytotoxicity and mutagenesis is facilitated by fatty acid hydroperoxidase activity in Chinese hamster lung fibroblasts (V79 cells), Mutation Res., 224, 185-196.
108. [108] Chaudhary, A.K., M. Nokubo, G.R. Reddy, S.N. Yeola, J.D. Morrow, I.A. Blair and L.J. Marnett (1994) Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver, Science, 265, 1580-1582.
109. [109] Park, E.M., M.K. Shigenaga P. Degan, T.S. Korn, J.W. Kitzler, C.M. Wehr, P. Kolachana and B.N. Ames (1992) Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column, Proc. Natl. Acad. Sci. USA, 89, 3375-3379.
110. 1 Mice (Gavage Studies), NTP TR 331, NIH Publ. No.89-2587, Research Triangle Park, NC.
111. [111] Vaca, C.E., J. Wilhelm and M. Harms-Ringdahl (1988) Interaction of lipid peroxidation products with DNA. A review, Mutation Res., 195, 137-149.
112. [112] IARC (1987) Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Vols. 1 to 42. International Agency for Research on Cancer, Lyon, pp. 152-154.
113. [113] Angel, P. and M. Karin (1991) The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation, Biochim. Biophys. Acta, 1072, 129-157.