Retroviral immunotoxin gene therapy of acute myelogenous leukemia in mice using cytotoxic T cells transduced with an interleukin 4/Diphtheria toxin gene

Cancer Research

Volumn 60, Issue 4, 2000, Pages 976-984

  Vallera, Daniel A ^a   Jin, Ni ^a   Baldrica, James M R ^a   Panoskaltsis Mortari, Angela ^b   Chen, Si Yi ^c   Blazar, Bruce R ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Div of Bone Marrow Transplantation   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; IMMUNOTOXIN; INTERLEUKIN 4; VIRUS VECTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RETROVIRUS;

3T3 CELLS; ANIMALS; DIPHTHERIA TOXIN; GENE THERAPY; GENE TRANSFER TECHNIQUES; IMMUNOTOXINS; INTERLEUKIN-4; KIDNEY; LEUKEMIA, MYELOCYTIC, ACUTE; LIVER; MICE; MICE, INBRED C57BL; RETROVIRIDAE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034652579     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Yee, C., Riddell, S. R., and Greenberg, P. D. Prospects for adoptive T cell therapy. Curr. Opin. Immunol., 9: 702-708, 1997.
2. Pardoll, D., and Topalian, S. L. The role of CD4+ T cell responses in antitumor immunity. Curr. Opin. Immunol., 10: 588-594, 1998.
3. Romano, G., Pacilio, C., and Giordano, A. Gene transfer technology in therapy: current applications and future goals. Oncologist, 3: 225-236, 1998.
4. Pawelec, G., Rees, R. C., Kiessling, R., Madrigal, A., Dodi, A., Baxevanis, C., Gambacorti-Passerini, C., Masucci, G., and Zeuthen, J. Cells and cytokines in immunotherapy and gene therapy of cancer. Crit. Rev. Oncog., 10: 83-127, 1999.
5. Collier, R. J. Diphtheria toxin: mode of action and structure. Bacteriol. Rev., 39: 54-85, 1975.
6. Honjo, T., Nishizuka, Y., and Hayaishi, O. Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J. Biol. Chem., 243: 3553-3555, 1968.
7. Murphy, J. R., and vanderSpek, J. C. Targeting diphtheria toxin to growth factor receptors. Semin. Cancer Biol., 6: 259-267, 1995.
8. Foss, F. M., Borkowski, T. A., Gilliom, M., Stetler-Stevenson, M., Jaffe, E. S., Figg, W. D., Tompkins, A., Bastian, A., Nylen, P., and Woodworth, T. Chimeric fusion protein toxin DAB486IL-2 in advanced mycosis fungoides and the Sezary syndrome: correlation of activity and interleukin-2 receptor expression in a Phase II study. Blood, 84: 1765-1774, 1994.
9. Parker, S., Tong, T., Bolden, S., and Wingo, P. Cancer statistics. CA Cancer J. Clin., 47: 5-12, 1997.
10. Wagteveld, A. J., van Zanten, A. K., Esselink, M. T., Halie, M. R., and Vellenga, E. Expression and regulation of IL-4 receptors on human monocytes and acute myeloblastic leukemic cells. Leukemia (Baltimore), 5: 782-788, 1991.
11. Debinski, W., Puri, R. K., Kreitman, R. J., and Pastan, I. A wide range of human cancers express interleukin 4 (IL-4) receptors that can be targeted with chimeric toxin composed of IL-4 and Pseudomonas exotoxin. J. Biol. Chem., 268: 14065-14070, 1993.
12. Puri, R. K., Hoon, D. S., Lelan, P., Snoy, P., Rand, R. W., Pastan, I., and Kreitman, R. J. Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. Cancer Res., 56: 5631-5637, 1996.
13. Buchsbaum, D. J., Laffoon, K. Rogers, B. E., Curiel, D. T., Khazaeli, M. B., McLean, S., Puri, R. K., Blazar, B. R., and Vallera, D. A. Radiolabeled DT390-mIL-4 fusion toxin binding and cytotoxicity to tumor cell induced to express mIL-4 receptor. Cancer Gene Ther., 4: S41, 1997.
14. Frankel, A. E., Tagge, E. P., and Willingham, M. C. Clinical trials of targeted toxins. Semin. Cancer Biol., 6: 307-317, 1995.
15. Saleh, M. N., LeMaistre, C. F., Kuzel, T. M., Foss, F., Platanias, L. C., Schwartz, G., Ratain, M., Rook, A., Freytes, C. O., Craig, F., Reuben, J., Sams, M. W., and Nichols, J. C. Antitumor activity of DAB3891L-2 fusion toxin in mycosis fungoides. J. Am. Acad. Dermatol., 39: 63-73, 1998.
16. Foss, F. M., Saleh, M. N., Krueger, J. G., Nichols, J. C., and Murphy, J. R. Diphtheria toxin fusion proteins. Curr. Top. Microbiol. Immunol., 234: 63-81, 1998.
17. Chan, C. H., Blazar, B. R., Eide, C. R., Kreitman, R. J., and Vallera, D. A. A murine cytokine toxin specifically targeting the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on normal committed bone marrow progenitor cells and GM-CSF-dependent tumor cells. Blood, 86: 2732-2738, 1995.
18. Chen, J. D., Bai, X., Yang, A. G., Cong, Y., and Chen, S. Y. Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy. Nat. Med., 3: 1110-1116, 1997.
19. 390-mIL-3, with bone marrow progenitor cells. Blood, 88: 1445-1451, 1996.
20. Durham, L. J., and Stewart, H. L. A survey of transplantable and transmissible animal tumors. J. Natl. Cancer Inst., 13: 1299-1377, 1953.
21. Bradner, W. T., and Pindell, M. H. Myeloid leukemia C1498 as a screen for cancer chemotherapeutic agents. Cancer Chemother. Screening Data, 43: 375-390, 1966.
22. Boyer, M. W., Vallera, D. A., Taylor, P. A., Gray, G. S., Katsanis, E., Gorden, K., Orchard, P. J., and Blazar, B. R. The role of B7 by murine acute myeloid leukemia cells in the generation and function of a CD8+ T cell line with potent in vivo graft-versus-leukemia properties. Blood, 89: 3477-3485, 1997.
23. Ohara, J., and Paul, W. E. Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression. Proc. Natl. Acad. Sci. USA, 85: 8221-8227, 1988.
24. 390-anti-CD3sFv, a single chain Fv fusion immunotoxin specifically targeting the CD3 epsilon moiety of the T cell receptor. Blood, 88: 2342-2353, 1996.
25. Matzinger, P. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods, 145: 185-192, 1991.
26. Kirkman, R. L., Bacha, P., Barrett, L. V, Forte S., Murphy, J. R and Strom, T. B. Prolongation of cardiac allograft survival in murine recipients treated with a diphtheria-toxin related interleukin-2 fusion protein. Transplantation, 47: 327-330, 1989
27. Lakkis, F., Steele, A., Pacheco-Silva, A., Rubin-Kelley, V., Strom, T. B., and Murphy, J. R. Interleukin-4 receptor targeted cytotoxicity: genetic construction and in vivo immunosuppressive activity of a diphtheria toxin-related murine IL-4 fusion protein. Eur. J. Immunol., 21: 2253-2258, 1991.
28. Hall, P. D., Kreitman, R. J., Willingham, M. C., and Frankel, A. E. Toxicology and pharmacokinetics of DT388-GM-CSF, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor (GM-CSF) in C57BL/6 mice. Toxicol. Appl. Pharmacol., 150: 91-97, 1998.
29. Rapoport, T. A., Rolls, M., and Jungnickel, B. Approaching the mechanism of protein transport across the ER membrane. Curr. Opin. Cell Biol., 8: 499-504, 1996.
30. Walter, P., and Johnson, A. E. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu. Rev. Cell Biol., 10: 87-119, 1994.
31. Miller, D. G., Adam, M. A., and Miller, A. D. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol., 10: 4239-4242, 1990.
32. Roe, T., Reynolds, T. C., Yu, G., and Brown, P. O. Integration of murine leukemia virus DNA depends on mitosis. EMBO J., 12: 2099-2108, 1993.
33. Chen, S-Y., Yang, A-G., Chen, J-D., Kute, T., King, R., Collers, J., Cong, Y., and Huang, X. Potent antitumour activity of a new class of tumour-specific killer cells. Nature (Lond.), 385: 78-82, 1997.
34. Cheever, M. A., Thompson, D. B., Klarnet, J. P., and Greenberg, P. D. Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory cells. J. Exp. Med., 163: 1100-1112, 1986.
35. Klarnet, J. P., Matis, L. A., Kern, D. E., Mizuno, M. T., Peace, D. J., Thomso, J. A, Greenberg, P. D., and Cheever, M. A. Antigen-driven T cell clones can proliferate in vivo, eradicate disseminated leukemia, and provide specific immunologic memory. J. Immunol., 138: 4012-4017, 1987.
36. Salgaller, M. L., and Lodge, P. A. Use of cellular and cytokine adjuvants in the immunotherapy of cancer. J. Surg. Oncol., 68: 122-138, 1998.
37. Kreitman, R. J., Puri, R. K., and Pastan, I. Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma. Cancer Res., 55: 3357-3363, 1995.
38. Jain, R. K. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl. Cancer Inst., 81: 570-576, 1989.