Toxicology and pharmacokinetics of DT388-GM-CSF, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor (GM-CSF)in C57BL/6 mice

Toxicology and Applied Pharmacology

Volumn 150, Issue 1, 1998, Pages 91-97

  Hall, Philip D ^a   Kreitman, Robert J ^b   Willingham, Mark C ^c   Frankel, Arthur E ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Hollings Cancer Center ^*

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; DIPHTHERIA TOXIN 388 GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; UNCLASSIFIED DRUG; DT(388) GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; DT(388) GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNOGLOBULIN G; IMMUNOTOXIN; PROTEIN SYNTHESIS INHIBITOR;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE KIDNEY TUBULE NECROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RESISTANCE; CELL STRAIN HL 60; DOSE RESPONSE; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LETHAL DOSE; MOUSE; MULTIDRUG RESISTANCE; NEPHROTOXICITY; NONHUMAN; ANIMAL; BONE MARROW; C57BL MOUSE; DRUG EFFECT; HALF LIFE TIME; IMMUNOLOGY; KIDNEY;

ANIMALIA;

ANIMALS; BONE MARROW; DIPHTHERIA TOXIN; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HALF-LIFE; HL-60 CELLS; HUMANS; IMMUNOGLOBULIN G; IMMUNOTOXINS; KIDNEY; MICE; MICE, INBRED C57BL; PROTEIN SYNTHESIS INHIBITORS;

EID: 0031595964     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8389     Document Type: Article

References (32)

1. Bast, R. C., Zalutsky, M. R., and Frankel, A. E. (1997). Monoclonal serotherapy. In Cancer Medicine (J. F. Holland, R. C. Bast, Jr., D. L. Morton, E. Frei, D. W. Kufe, and R. R. Weichselbaum, Eds.), pp. 1245-1262. Williams & Wilkins, Baltimore, MD.
2. Chan, C. H., Blazar, B. R., Eide, C. R., Kreitman, R. J., and Vallera, D. A. (1995). A murine cytokine fusion toxin specifically targeting the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on normal committed bone marrow progenitor cells and GM-CSF-dependent tumor cells. Blood 86, 2732-2740.
3. Chiba, S., Shibuya, K., and Piao, Y. F. (1990). Identification and cellular distribution of distinct proteins forming human GM-CSF receptor. Cell Regul. 1, 327-335.
4. Choe, S., Bennett, M. T., Fuji, G., Curmi, P. M. G. (1992). The crystal structure of diphtheria toxin. Nature. 357, 216-222.
5. Fraker, P. J., and Speck, J. C. (1978). Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenyl-glycoluril. Biochem. Biophys. Res. Commun. 80, 849-857.
6. Frankel, A. E., Hall, P. D., Burbage, C., Vesely, J., Willingham, M. C., Bhalla, K., and Kreitman, R. J. (1997). Modulation of the apoptotic response of human myeloid leukemia cells to diphtheria toxin-granulocyte-macrophage colony stimulating factor fusion protein. Blood 90, 3654-3661.
7. Gordon, V. M., Klimpel, K. R., Arora, N., Henderson, M. A., Leppla, S. H. (1995). Proteolytic activation of bacterial toxins by eukaryocytic cells is performed by furin and by additional cellular proteases. Infect. Immunol. 63, 82-87.
8. Hayashida, K., Kitamura, T., Goman, D. M., Arai, K., Yokota, T., Miyajima, T. (1990). Molecular cloning of a second subunit of the receptor form human granulocyte-macrophage colony-stimulating factor (GM-CSF): Regulation of a high-affinity GM-CSF receptor. Proc. Natl. Acad. Sci. USA 87, 9655-9659.
9. Hooper, K., and Eidels, L. (1995). Localization of a critical diphtheria toxin-binding domain to the C-terminus of the mature heparin-binding EGF-like growth factor region of the diphtheria toxin receptor. Biochem. Biophys. Res. Commun. 206, 710-714.
10. Kelleher, C., Wong, G., Clark, S., Schendel, P., Minden, M., McCulloch, E. (1988). Binding of iodinated recombinant human GM-CSF to the blast cells of acute myeloblastic leukemia. Leukemia 2, 211-215.
11. Kirkman, R. L., Bacha, P., Barrett, L. V., Forte, S., Murphy, J. R., Strom, T. B. Prolongation of cardiac allograft survival in murine recipients treated with a diphtheria toxin-related interleukin-2 fusion protein. Transplantation 47, 327-330.
12. Kreitman, R. J., and Pastan, I. (1997). Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either Pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells. Blood 90, 252-259.
13. Kurata, H., Arai, T., Yokota, T., Arai, K. (1995). Differential expression of granulocyte-macrophage colony-stimulating factor and IL-3 receptor status on human CD34+ cells and leukemic cell lines. J. Allergy Clin. Immunol. 96, 1083-1099.
14. Lakkis, F., Steele, A., Pacheco-Silva, A., Rubin-Kelley, V., Strom, T. B., Murphy, J. R. (1991). Interleukin 4 receptor targeted cytotoxicity: Genetic construction and in vivo immunosuppressive activity of diphtheria toxin-related murine interleukin 4 fusion protein. Eur. J. Immunol. 21, 2253-2258.
15. Mayer, R. J., Davis, R. B., Schiffer, C. A., Berg, D. T., Powell, B. L., Schulman, P., Omura, G. A., Moore, J. O., McIntyre, O. R., Frei, E., for the Cancer and Leukemia Group B. (1994). Intensive postremission chemotherapy in adults with acute myeloid leukemia. N. Engl. J. Med. 331, 896-903.
16. McKinstry, W. J., Li, C. L., Rasko, J. E. J., Nicola, N. A., Johnson, G. R., Metcalf, D. (1997). Cytokine receptor expression on hematopoietic stem and progenitor cells. Blood. 89, 65-71.
17. Metcalf, D. (1986). The molecular biology and functions of granulocyte-macrophage colony stimulating factors. Blood 67, 257-267.
18. McKinstry, W. J., Li, C. L., Rasko, J. E. J., Nicola, N. A., Johnson, G. R., Metcalf, D. (1997). Cytokine receptor expression on hematopoietic stem and progenitor cells. Blood 89, 65-71.
19. Naglich, J. G., Metherall, J. E., Russell, D. W., Eidels, L. (1992). Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 69, 1051-1061.
20. Nicola, N. A., Peterson, L., Hilton, D. J., Metcalf, D. (1988). Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hematopoietic cells and cell lines. Growth Factors 1, 41-49.
21. Pappenheimer, A. M., Harper, A. A., Moynihan, M., Brockes, J. P. (1981). Diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells. J. Infect. Dis. 145, 94-99.
22. Parker, S. L., Tong, T., Bolden, S., Wingo, P. A. (1997). Cancer statistics, 1997. CA Cancer J. Clin. 47, 5-27.
23. Pastore, C. J., Isner, J. M., Bacha, P. A., Kearney, M., Pickering, J. G. (1995). Epidermal growth factor receptor-targeted cytotoxin inhibits neointimal hyperplasia in vivo: Results of local versus systemic administration. Circ. Res. 77, 519-529.
24. Raso, V., McGrath, J. (1989). Cure of experimental human malignant mesothelioma in athymic mice by diphtheria toxin. J. Natl. Cancer Inst. 81, 622-627.
25. Stanley, E., Lieschke, G. J., Grail, D., Metcalf, D., Hodgson, G., Gall, J. A., Maher, D. W., Cebon, J., Sinickas, V., Dunn, A. R. (1994). Granulocyte/ macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc. Natl. Acad. Sci. USA 91, 5592-5596.
26. Strom, T., Kelley, V., Murphy, J., Nichols, J., Woodworth, T. (1994). Interleukin-2 receptor-directed therapies: Antibody- or cytokine-based targeting molecules. Adv. Nephrol. 23, 347-352.
27. Sung, C., Youle, R. J., Dedrick, R. L. (1990). Pharmacokinetic analysis of immunotoxin uptake in solid tumors: Role of plasma kinetics, capillary permeability, and binding. Cancer Res. 50, 77382-7392.
28. van Hess, B. G., Howard, J. B., Bodley, J. W. (1980). ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products. J. Biol. Chem. 255, 10717-10720.
29. Vogler, W. R., Velez-Garcia, E., Weiner, R. S., Flaum, M. A., Bartolucci, A. A., Omura, G. A., Gerber, M. C., Banks, P. L. C. (1992). A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: A southeastern cancer study group study. J. Clin. Oncol. 10, 1103-1111.
30. 486-IL2): Fragment B sequences required for delivery of fragment A to the cytosol of target cells. J. Biol. Chem. 265, 11885-11889.
31. Yamaizumi, M., Mekada, E., Uchida, T., Okada, Y. (1978). One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 15, 245-250.
32. Zittoun, R. A., Mandelli, F., Willemze, R., de Witte, T., Labar, B., Resegotti, L., Leoni, F., Damasio, E., Visani, G., Papa, G., Caronia, F., Hayat, M., Stryckmans, P., Rotoli, B., Leoni, P., Peetermans, M. E., Dardenne, M., Vegna, M. L., Petti, M. C., Solbu, G., Suciu, S., for the European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne Dell' Adulto (GIMEMA) Leukemia Cooperative Groups (1995). Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N. Eng. J. Med. 332, 217-223.