A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase

Biochemistry

Volumn 37, Issue 20, 1998, Pages 7096-7102

  Williams, Angela W ^a   Bruce Dunlap, R ^a   Berger, Sondra H ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; LIGAND BINDING; PRIORITY JOURNAL; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANTIBODIES, MONOCLONAL; CATALYSIS; COLONIC NEOPLASMS; DITHIONITROBENZOIC ACID; FLUORODEOXYURIDYLATE; GENETIC COMPLEMENTATION TEST; HUMANS; HYDROXYL RADICAL; KINETICS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE; TITRIMETRY; TUMOR CELLS, CULTURED;

BACTERIA (MICROORGANISMS); FELIS CATUS;

EID: 0344734178     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972562+     Document Type: Article

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