Binding of EcoP15i DNA methyltransferase to DNA reveals a large structural distortion within the recognition sequence

Journal of Molecular Biology

Volumn 298, Issue 4, 2000, Pages 597-610

  Reddy, Yeturu V R ^a   Rao, Desirazu N ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Adenine methyltransferase; Base flipping; DNA distortion; DNA protein interactions

Indexed keywords

ADENINE; DNA METHYLTRANSFERASE; DOUBLE STRANDED DNA;

ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA CONFORMATION; DNA FOOTPRINTING; DNA HELIX; DNA METHYLATION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SEQUENCE ANALYSIS;

ESCHERICHIA COLI;

EID: 0034640127     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3673     Document Type: Article

References (48)

1. Interaction of EcoP15I DNA methyltransferase with oligonucleotides containing the asymmetric sequence 5'-CAGCAG-3
2. Chemistry and biology of DNA methyltransferases
3. Functional analysis of conserved motifs in EcoP15I DNA methyltransferase
4. DNA recognition by the EcoP15I and EcoPI modification methylases
5. Targeted base-stacking disruption by the EcoRI DNA methyltransferase
6. Direct real time observation of base flipping by the EcoRI DNA methyltransferase
7. Crystal structure of a G:T/U mismatch-specific DNA glycosylase: Mismatch recognition by complementary-strand interactions. Cell
8. The double role of methyl donor and allosteric effector of S-adenosyl-L-methionine for Dam methylase of E. coli
9. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding
10. The EcoRV modification methylase causes considerable bending of DNA upon binding to its recognition sequence GATATC
11. DNA distortion and base flipping by the EcoRV DNA methyltransferase. A study using interference at dA and T bases and modified deoxynucleosides
12. Finding a basis for flipping bases
13. DNA glycosylases
14. Bacterial DNA methyltransferases
15. 5 methyltransferase
16. 4) methyltransferase, an example of domain permutation and protein folding assignment
17. The selective degradation of pyrimidines in nucleic acids by permanganate oxidation
18. 2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases
19. Protein-mediated base flipping
20. Structure of the DNA repair enzyme Endonuclease IV and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis
21. 6 DNA methyltransferase
22. M.HhaI binds tightly to substrates containing mismatches at the target base
23. HhaI methyltransferase flips its target base out of the DNA helix
24. Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution
25. Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping
28. Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes
29. 6-adenine] methyltranferase with oligonucleotides containing native or modified (defective) recognition sites
30. 6-adenine] methyltransferase
31. M.EcoP15I methylates the second adenine in its recognition sequence
32. High resolution footprinting of a type I methyltransferase reveals a large structural distortion within the DNA recognition site
33. Interaction of the type I methyltransferase M.EcoR124I with modified DNA substrates: Sequence discrimination and base flipping
34. Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base
35. 6-adenine DNA methyltransferase from Thermus aquaticus
36. Probing the role of cysteine residues in the EcoP15I DNA methyltransferase
37. The crystal structure of HaeIII methyl-transferase covalently complexed to DNA: An extrahelical cytosine and rearranged base-pairing
38. Base flipping
39. Chemical display of thymine residues flipped out by DNA methyltransferases
40. Lack of correlation between binding of EcoRII methylase to DNA duplexes containing mismatches and the promotion of C to T mutations
41. A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA
42. Biological implications of the mechanism of action of human DNA (cytosine-5) methyltransferase
43. Crystal structure of the DpnM DNA adenine methyltransferase from the DpnII restriction system of Streptococcus pneumoniae bound to S-adenosyl-L-methionine
44. DNA-repair enzymes
45. Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: Structural basis for damaged DNA recognition
46. Fluorescence studies of nucleotides and polynucleotides. I. Formycin, 2-aminopurine riboside, 2,6-diaminopurine riboside and their derivatives
47. Hha1 and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair