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Volumn 122, Issue 14, 2000, Pages 3546-3547

Assembly of mesoscopic analogues of nucleic acids [13]

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA;

EID: 0034639926     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja994099p     Document Type: Letter
Times cited : (26)

References (31)
  • 13
    • 33646282924 scopus 로고    scopus 로고
    • The size of the AnBs is large enough to see and manipulate without magnification, and small enough that an interesting number can be incorporated into a single chain and studied in a standard-sized Petri dish
    • The size of the AnBs is large enough to see and manipulate without magnification, and small enough that an interesting number can be incorporated into a single chain and studied in a standard-sized Petri dish.
  • 15
    • 33646330962 scopus 로고    scopus 로고
    • The transparencies were created using Freehand 8.0 (Macromedia) as drawing program and printed using a 3386 dpi laser image setter
    • The transparencies were created using Freehand 8.0 (Macromedia) as drawing program and printed using a 3386 dpi laser image setter.
  • 16
    • 33646300832 scopus 로고    scopus 로고
    • The 3-in. diameter silicon wafers that we used as substrates for photolithography did not allow fabrication of strands of more than 25 AnBs. Longer strands were fabricated by joining several short strands by hand using the dovetail tongue and groove and gluing
    • The 3-in. diameter silicon wafers that we used as substrates for photolithography did not allow fabrication of strands of more than 25 AnBs. Longer strands were fabricated by joining several short strands by hand using the dovetail tongue and groove and gluing.
  • 18
    • 33646314966 scopus 로고    scopus 로고
    • The correction fluid was removed by carefully taking the pieces off the Scotch tape-covered glass slide with tweezers. The dried correction fluid remained stuck to the Scotch tape; separating the strands from this protective film revealed the Hydrophobie faces
    • The correction fluid was removed by carefully taking the pieces off the Scotch tape-covered glass slide with tweezers. The dried correction fluid remained stuck to the Scotch tape; separating the strands from this protective film revealed the Hydrophobie faces.
  • 19
    • 33646304175 scopus 로고    scopus 로고
    • -1 to accelerate collisions, to break up weak structures, and to stimulate annealing
    • -1 to accelerate collisions, to break up weak structures, and to stimulate annealing.
  • 20
    • 33646303842 scopus 로고    scopus 로고
    • Self-assembly takes place by the aggregation of one AnB followed by the assembly of the whole probe along the strand. In case of a mismatch, the probe dissociates from the long strand. This process repeats itself several times (on-off cycling) until the correct assembly generates a stable aggregate
    • Self-assembly takes place by the aggregation of one AnB followed by the assembly of the whole probe along the strand. In case of a mismatch, the probe dissociates from the long strand. This process repeats itself several times (on-off cycling) until the correct assembly generates a stable aggregate.
  • 21
    • 33646273699 scopus 로고    scopus 로고
    • -1. Because the dish had a large diameter, more vigorous agitation resulted in large surface waves and the formation of bubbles of air at the water/PFD interface
    • -1. Because the dish had a large diameter, more vigorous agitation resulted in large surface waves and the formation of bubbles of air at the water/PFD interface.
  • 22
    • 33646325228 scopus 로고    scopus 로고
    • We investigated the self-assembly of small eight-mer probes with two and four mismatches in their sequences: No stable aggregates were observed
    • We investigated the self-assembly of small eight-mer probes with two and four mismatches in their sequences: No stable aggregates were observed.
  • 23
    • 33646327134 scopus 로고    scopus 로고
    • The observation that the probability of pairing is lower in these systems than in molecular DNA can be explained by the different strengths of the agitation, the limitated degrees of freedom of the systems (2D versus 3D) and by the lower probability of collisions between strands
    • The observation that the probability of pairing is lower in these systems than in molecular DNA can be explained by the different strengths of the agitation, the limitated degrees of freedom of the systems (2D versus 3D) and by the lower probability of collisions between strands.
  • 24
    • 33646301824 scopus 로고    scopus 로고
    • We believe that this strategy can be applied to AnBs with smaller dimensions; using these structures will make it possible to explore longer and more complex sequences
    • We believe that this strategy can be applied to AnBs with smaller dimensions; using these structures will make it possible to explore longer and more complex sequences.
  • 30


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.