Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus 1 or gp120 mediated by endogenous transforming growth factor β1

Journal of Experimental Medicine

Volumn 183, Issue 1, 1996, Pages 99-108

  Zauli, Giorgio ^a   Vitale, Marco ^b,c   Gibellini, Davide ^d   Capitani, Silvano ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c c/o Inst of Res Codivilla Putti ^*  (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GLYCOPROTEIN GP 120; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL GROWTH; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; CYTOPENIA; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NORMAL HUMAN; PRIORITY JOURNAL;

ANTIGENS, CD34; BASE SEQUENCE; CELL CYCLE; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; FEMALE; HEMATOPOIETIC STEM CELLS; HIV ENVELOPE PROTEIN GP120; HIV SEROPOSITIVITY; HIV-1; HUMANS; LEUKOPENIA; MALE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 0030071481     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.1.99     Document Type: Article

References (44)

1. Zon, L.I., C. Arkin, and J.E. Groopman. 1987. Haematologic manifestation of the human immune deficiency virus (HIV). Br. J. Haematol. 66:251-256.
2. Zauli, G., and B.R. Davis. 1993. Role of HIV infection in the hematologic manifestations of HIV seropositive subjects. Crit. Rev. Oncol. Hematol. 15:271-283.
3. Davis, B.R., J.C. Marx, C.E. Johnson, J.M. Berry, J. Lyding, A. Zander, T.C. Merigan, and J. Schwartz. Absent or rare HIV infection of bone marrow stem/progenitor cells in vivo. J. Virol. 65:1985-1990.
4. +) progenitor cells in AIDS patients. J. Infect Dis. 166:710-716.
5. + bone marrow cells are infected with HIV in a subset of seropositive individuals. J. Immunol. 149:689-697.
6. + progenitor cells are not infected by HIV-1 in vivo but show impaired clonogenesis. Br. J Haematol. 85:20-28.
7. +) hematopoietic progenitors in HIV-1 seropositive thrombocytopenic individuals. Blood. 79:2680-2687.
8. + hematopoietic progenitor cells are not a major reservoir of the human immunodeficiency virus. Blood. 76:1281-1286.
9. Molina, J.M., D.T. Scadden, M. Sakaguchi, B. Fuller, A. Woon, and J.E. Groopman. 1990. Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus. Blood. 76:2476-2482.
10. Folks, T.M., S.W. Kessler, J.M. Orenstein, J.S. Justment, E. Laffe, and A.S. Fauci. 1988. Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow. Science (Wash. DC). 242:919-922.
11. Kitano, K., C.N. Abboud, D.H. Ryan, S.G. Quan, G.C. Baldwin, and D.W. Golde. 1991. Macrophage-active colony-stimulating factors enhance human immunodeficiency virus type 1 infection in bone marrow stem cells. Blood. 77: 1699-1706.
12. Steinberg, H.N., C.S. Crumpacker, and P.A. Chatis. 1991. In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J. Virol. 65: 1765-1769.
13. Chelucci, C., H.J. Hassan, C. Locar, D. Bulgarini, C. Pelosi, G. Mariani, U. Testa, M. Federico, M. Valtieri, and C. Peschle. 1995. In vitro human immunodeficiency virus-1 infection of purified hematopoietic progenitors in single-cell culture. Blood. 85:1181-1187.
14. + cells). J. Gen. Virol. 73:417-421.
15. Maciejwski, J.P., F.F. Weichold, and N.S. Young. 1994. HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-α. J. Immunol. 53:4303-4310.
16. Zauli, G., M. Vitale, M.C. Re, G. Furlini, L. Zamai, E. Falcieri, D. Gibellini, G. Visani, B.R. Davis, S. Capitani, and M. La Placa. 1994. In vitro exposure to human immunodeficiency virus type-1 (HIV-1) induces apoptotic cell death of the factor-dependent TF-1 hematopoietic cell line. Blood. 83: 167-175.
17. + hematopoietic progenitors express low levels of CD4, the high affinity receptor for human immunodeficiency virus-type 1. Blood. 84:1896-1905.
18. Louache, F., N. Debili, A. Marandin, L. Coulombel, and W. Vainchenker. 1994. Expression of CD4 by human hematopoietic progenitors. Blood. 84:3344-3355.
19. Hatzfeld, J., M.L. Li, E.L. Brown, H. Sookdeo, J.P. Levesque, T. O'Toole, C. Gurney, S.C. Clark, and A. Hatzfeld. 1991. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth β1 or Rb oligonucleotides. J. Exp. Med. 174:925-929.
20. - human umbilical cord blood cells reveals their potentiality to engraft adults. Proc. Natl. Acad. Sci. USA. 90:8707-8711.
21. Keller, J.R., G.K. Sing, L.R. Ellingsworth, and F.W. Ruscetti. 1989. Transforming growth factor-β: possible roles in the regulation of normal and leukemic hematopoietic cell growth. J. Cell. Biochem. 39:175-183.
22. Robinson, J.D. 1993. Handbook of Flow Cytometry Methods. Wiley-Liss, New York.
23. Kekow, J., W. Wachsman, A. McCutchan, M. Cronin, D.A. Carson, and M. Lotz. 1990. Transforming growth factor-β and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc. Natl. Acad. Sci. USA. 87:8321-8325.
24. Derynck, R., J.A. Jarrett, E.Y. Chen, D.H. Heaton, J.R. Bell, R K. Assoian, A.B. Roberts, M.B. Sporn, and D.V. Goeddel. 1985. Human transforming growth factor β complementary DNA sequence and expression in normal and transformed cells. Nature (Lond.). 316:701-705.
25. Hanks, S.K., R. Armour, J.H. Baldwin, F. Maldonado, J. Spiess, and R.W. Holley. 1988. Amino acid sequences of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of cDNA. Proc. Natl. Acad. Sci USA. 85:79-82.
26. Tucker, R.F., G.D. Shipley, H.L. Moses, and R.W. Holley. 1984. Growth inhibitor from BSC-1 cells closely related to platelet type β transforming growth factor. Science (Wash. DC). 226:705-707.
27. Zauli, G., B.R. Davis, M.C. Re, G. Visani, G. Furlini, and M. La Placa. 1992. Tat protein stimulates production of transforming growth factor-beta 1 by marrow macrophages: a potential mechanism for HIV-1 induced hematopoietic suppression. Blood. 80:3036-3043.
28. + cells in the presence of various combinations of recombinant cytokines under serum-free culture conditions. Br. J. Haematol. 86:461-467.
29. Ohta, M., J.S. Greenberger, P. Anklesaria, A. Bassols, and J. Massagué. 1987. Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells. Nature (Lond.). 329:539-541.
30. + human hematopoietic progenitor cells through different kinetic mechanisms depending on the applied stimulus. Exp. Hematol. 22:903-909.
31. Li, C.Y., L. Suardet, and J.B. Little. 1995. Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. J. Biol. Chem. 270:4971-4974.
32. Selvakumaran, M., H.K. Lin, T. Miyashita, H.G. Wang, S. Krajewki, J.C. Reed, B. Hoffman, and D. Liebermann. 1994. Immediate early up-regulation of bax expression by p53 but not TGFβ1: a paradigm for distinct apoptotic pathways. Oncogene. 9:1791-1798.
33. Krystal, G., V. Lam, W. Dragowska, C. Takahashi, J. Appel, A. Gontier, A. Jenkins, H. Lam, L. Quon, and P. Lansdorp. 1994. Transforming growth β1 is an inducer of erythroid differentiation. J. Exp. Med. 180:851-860.
34. Allen, J.B., H.L. Wong, P.M. Guyre, G.L. Simon, and S.M Wahl. 1991. Association of circulating receptor FcgRIII-positive monocytes in AIDS patients with elevated levels of transforming growth factor-β. J. Clin. Invest. 87:1773-1779.
35. Kim, S.J., P. Angel, R. Lafyatis, K. Hattori, K.Y. Kim, M.B Sporn, M. Karin, and A.B. Roberts. 1990. Autoinduction of transforming growth factor β1 is mediated by the AP-1 complex. Mol. Cell. Biol. 10:1492-1501.
36. Moore, M.A.S., D. Phil, and F. Shapiro. 1994. Regulation and function of hematopoietic stem cells. Curr. Opin. Hematol. 1:180-186.
37. Laiho, M., J.A. DeCaprio, J.W. Ludlow, D.M. Livingston, and J. Massagué. 1990. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation Cell. 62:125-134.
38. Furukawa, Y., S. Uenoyama, M. Ohta, A. Tsunoda, J.D Griffin, and M. Saito. 1992. Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-1. J. Biol. Chem. 267:17121-17127.
39. Ando, K., and J.D. Griffin. 1995. Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells. Oncogene. 10:751-755.
40. de Vos, S., M.A. Brach, Y. Asano, W.D. Ludwig, P. Bettelheim, H.J. Gruss, and F. Herrmann. 1993. Transforming growth factor-β1 interferes with the proliferation-inducing activity of stem cell factor in myelogenous leukemia blasts through functional down-regulation of the c-kit proto-oncogene product. Cancer Res. 53:3638-3645.
41. Fauci, A.S. 1993. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science (Wash. DC). 262:1011-1018.
42. Wahl, S.M., J.B. Allen, N. McCartney-Francis, M.C Morganti-Kossman, T. Kossman, L. Ellingsworth, U.E. Mai, S.E. Mergenhagen, and J.M. Orenstein. 1991. Macrophage- and astrocyte-derived transforming growth factor β as a mediator of the central nervous system dysfunction in acquired immunodeficiency syndrome. J. Exp. Med. 173:981-991.
43. Gibellini, D., G Zauli, M.C. Re, D. Milani, G. Furlini, E. Caramelli, S. Capitani, and M. La Placa. 1994. Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially upregulates IL-6 and TGF-β1 mRNA expression and protein synthesis in peripheral blood monocytes. Br. J. Haematol. 88:261-267.
44. Louache F., A. Henri, A. Bettaieb, E. Oksenhendler, G. Raguin, M. Tulliez, and W. Vainchenker. 1992. Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors. Blood. 80:2991-2999.