CCR5 and CXCR4 chemokine receptor expression and β-chemokine production during early T cell repopulation induced by highly active anti-retroviral therapy

Clinical and Experimental Immunology

Volumn 118, Issue 1, 1999, Pages 87-94

  Giovannetti, A ^a   Ensoli, F ^a   Mazzetta, F ^a   De Cristofaro, M ^a   Pierdominici, M ^a   Muratori, D S ^a   Fiorelli, V ^a   Aiuti, F ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Chemokine receptors; HIV HAART; chemokines

Indexed keywords

ANTIRETROVIRUS AGENT; BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; MACROPHAGE INFLAMMATORY PROTEIN 1; RANTES;

ADULT; ANTIBODY PRODUCTION; ANTIVIRAL ACTIVITY; ARTICLE; CELL COMPARTMENTALIZATION; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; HUMAN; MALE; MEMORY CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION; TARGET CELL; VIRUS LOAD;

EID: 0032881352     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01033.x     Document Type: Article

References (30)

1. 1 Dragic T, Litwin V, Allaway GP et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667-73.
2. 2 Deng H, Liu R, Ellmeier W et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996; 381:661-6.
3. 3 Choe H, Farzan M, Sun Y et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996; 85:1135-48.
4. 4 Carroll RG, Riley JL, Levine BL, Blair PJ, St LD, June CH. The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes. Semin Immunol 1998; 10:195-202.
5. 5 Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272:872-7.
6. 6 Ruiz ME, Cicala C, Arthos J et al. Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV. J Immunol 1998; 161:4169-76.
7. 7 Schuitemaker H, Koot M, Kootstra NA et al. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol 1992; 66:1354-60.
8. 8 Zhu T, Mo H, Wang N et al. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 1993; 261:1179-81.
9. 9 Xiao L, Rudolph DL, Owen SM, Spira TJ, Lal RB. Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progression. Aids 1998; 12:F137-43.
10. 10 Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997; 94: 1925-30.
11. 11 Wu L, Paxton WA, Kassam N et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 1997; 185:1681-91.
12. 12 Mo H, Monard S, Pollack H et al. Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood. Aids Res Hum Retrovir 1998; 14:607-17.
13. 13 Ostrowski MA, Justement SJ, Catanzaro A et al. Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals. J Immunol 1998; 161:3195-201.
14. 14 Pakker NG, Notermans DW, de Boer BR et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 1998; 4:208-14.
15. 15 Autran B, Carcelain G, Li TS et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997; 277:112-6.
16. 16 Pakker NG, Roos MT, van Leeuwen LR et al. Patterns of T-cell repopulation, virus load reduction, and restoration of T-cell function in HIV-infected persons during therapy with different antiretroviral agents. J Acquir Immune Defic Syndr Hum Retrovir 1997; 16:318-26.
17. 17 Li TS, Tubiana R, Katlama C, Calvez V, Ait MH, Autran B. Longlasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 1998; 351:1682-6.
18. 18 Komanduri KV, Viswanathan MN, Wieder ED et al. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nat Med 1998; 4:953-6.
19. 19 Pandolfi F, Alario C, Girardi E et al. The Italian quality control study for evaluation of CD4 cells in centres involved in the treatment of HIV-1 patients. Italian CD4 Quality Control Group. Clin Exp Immunol 1998; 111:564-73.
20. 20 Mulder JRR, Saget B, Scheibel S, Herman S, Payne H, Harrigan R, Kwok S. A rapid and simple method for extracting human immunodeficiency virus type 1 RNA from plasma: enhanced sensitivity. J Clin Microbiol 1997; 35:1278-80.
21. 21 Schockmel GA, Yerly S, Perrin L. Detection of low HIV-1 RNA levels in plasma. J Acquir Immune Defic Syndr Hum Retrovir 1997; 14:179-83.
22. 22 Fiorelli V, Gendelman R, Samaniego F, Markham PD, Ensoli B. Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. J Clin Invest 1995; 95:1723-34.
23. 23 Bunce C, Bell EB. CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. J Exp Med 1997; 185:767-76.
24. 24 Bell EB, Sparshott SM, Bunce C. CD4+ T-cell memory, CD45R subsets and the persistence of antigen - a unifying concept. Immunol Today 1998; 19:60-64.
25. 25 Picker LJ, Treer JR, Ferguson-Darnell B, Collins PA, Buck D, Terstappen LW. Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J Immunol 1993; 150:1105-21.
26. 26 Mackay CR. T-cell memory: the connection between function, phenotype and migration pathways. Immunol Today 1991; 12:189-92; 184-192.
27. 27 Bermejo M, Martin SJ, Oberlin E et al. Activation of blood T lymphocytes down-regulates CXCR4 expression and interferes with propagation of X4 HIV strains. Eur J Immunol 1998; 28:3192-204.
28. 28 Cocchi F, DeVico AL, Garzino DA, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995; 270:1811-5.
29. 29 Andersson J, Fehniger TE, Patterson BK et al. Early reduction of immune activation in lymphoid tissue following highly active HIV therapy. Aids 1998; 12:F123-9.
30. 30 Miller MD, Krangel MS. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 1992; 12:17-46.