Inhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867

Journal of Endocrinology

Volumn 152, Issue 1, 1997, Pages 155-158

  Cheng, K ^a   Wei, L ^a   Chaung, L Y ^a   Chan, W W S ^a   Butler, B ^a   Smith, R G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; L 756867; SUBSTANCE P ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FEMALE; HORMONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

EID: 0031021761     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1520155     Document Type: Article

References (14)

1. Bitar KG, Bowers CY & Coy DH 1991 Effect of substance P/bombesin antagonists on the release of growth hormone by GHRP and GHRH. Bochemical and Biophysical Research Communications 180 156-161.
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3. 2 on growth honnone(GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124 2791-2798.
4. Cheng K, Chan WWS, Butler B, Wei L, Schoen W, Wyvratt MJ, Fisher MH & Smith RG 1993a Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue. Endocrinology 132 2729-2731.
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7. Cheng K, Wei L, Chaung LY, Chan WWS, Butler B, Pong SS & Smith RG 1994 Substance P antagonist inhibits L-692,429- and GHRP-6-stimulated rat growth hormone release both in vitro and in vivo. Endocrine Society 76th Annual Meeting, Anaheim, CA, USA, p366.
8. Gertz BJ, Barrett JS, Esienhandler R, Krupa DA, Wittreich JM, Seibold JR & Schneider SH 1993 Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone releasing peptide. Journal of Clinical Endocrinology and Metabolism 77 1393-1397.
9. Hickey G, Jacks T, Judith F, Taylor J, Schoen W, Krupa D, Cunningham P, Clark J & Smith RG 1994 In vivo efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue in beagles. Endocrinology 134 695-701.
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