Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 11, 2000, Pages 1167-1169

  Fotouhi, Nader ^a   Joshi, Pramod ^a   Tilley, Jefferson W ^a   Rowan, Karen ^a   Schwinge, Virginia ^a   Wolitzky, Barry ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CYCLIC SULFIDE; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

INTEGRIN ALPHA4BETA1; INTEGRINS; MOLECULAR MIMICRY; PEPTIDES, CYCLIC; RECEPTORS, LYMPHOCYTE HOMING; SULFIDES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0034608594     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00175-X     Document Type: Article

References (8)

1. Elices, M. Curr. Opin. in Antiinflammat. and Immunomodulat. Investigat. Drugs 1999, 1, 14. Elices, M. In Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases, Mousa, S. A. Ed.; Springer-Verlag: 1998, pp 133-147.
2. Elices, M. Curr. Opin. in Antiinflammat. and Immunomodulat. Investigat. Drugs 1999, 1, 14. Elices, M. In Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases, Mousa, S. A. Ed.; Springer-Verlag: 1998, pp 133-147.
3. Lin K.-C., Castro A.C. Curr. Opin. Chem. Biol. 2:1998;453.
4. Lin, K.-c., Ateeq, H. S.; Hsiung, S. H.; Chong, L. T.; Zimmerman, C. N.; Castro, A.; Lee. W.-c.; Hammond C. E.; Kalkunte, S.; Chen, L.-L.; Pepinsky, R. B.; Leone, D. R.; Sprague, A. G.; Abraham, W. M.; Gill, A.; Lobb, R. A.; Adams, S. P. J. Med. Chem. 1999, 42, 920.
5. Lobb R.R., Adams S.P. Exp. Opin. Invest. Drugs. 8:1999;935.
6. Fotouhi N., Joshi P., Fry D., Cook C., Tilley J.W., Kaplan G., Hanglow A., Rowan R., Schwinge V., Wolitzky B. Bioorg. Med. Chem. Lett. 10:2000;1171.
7. Jackson D., Quan C., Artis D.R., Rawson T., Blackburn B., Struble M., Fitzgerald G., Chan K., Mullins S., Burnier J.P., Fairbrother W.J., Clark K., Berisini M., Chui H., Renz M., Jones S., Fong S. J. Med. Chem. 40:1997;3359.
8. Chen, L.; Guthrie, R. W.; Huang, T.-N.; Hull, K. G.; Sidduri, A.; Tilley, J. W. WO 9910312, 1999.