Changes in tactile stimuli-induced behavior and c-Fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush

Journal of Comparative Neurology

Volumn 428, Issue 1, 2000, Pages 45-61

  Bester, Hervé ^a   Beggs, Simon ^a   Woolf, Clifford J ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Allodynia; Dorsal horn; Nerve injury; Pain, plasticity; Parabrachial area

Indexed keywords

PROTEIN C FOS;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; MALE; MECHANORECEPTOR; NERVE CELL; NERVE CELL PLASTICITY; NERVE REGENERATION; NOCICEPTION; NONHUMAN; PAIN; PARABRACHIAL NUCLEUS; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCIATIC NERVE; SPINAL CORD DORSAL HORN; TACTILE STIMULATION; TOUCH;

ANIMALS; CELL COUNT; MALE; MESENCEPHALON; NERVE CRUSH; NERVE REGENERATION; NEURONAL PLASTICITY; NOCICEPTORS; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; PONS; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; TOUCH;

EID: 0034606571     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9861(20001204)428:1<45::AID-CNE5>3.0.CO;2-A     Document Type: Article

References (105)

1. Organization of the efferent projections from the pontine parabrachial area to the bed nucleus of the stria terminalis and neighboring regions: A PHA-L study in the rat
2. Modality-specific hyper-responsivity of regenerated cat cutaneous nociceptors
3. Altered c-fos expression in the parabrachial nucleus in a rodent model of CFA-induced peripheral inflammation
4. NGF but not NT-3 or BDNF prevents the A fiber sprouting into lamina II of the spinal cord that occurs following axotomy
5. An animal model of neuropathic pain: A review
6. A possible spino (trigemino)-ponto-amygdaloid pathway for pain
7. The spino(trigemino)pontoamygdaloid pathway: Electrophysiological evidence for an involvement in pain processes
8. The organization of the efferent projections from the pontine parabrachial area to the amygdaloid complex: A Phaseolus vulgaris leucoagglutinin (PHA-L) study in the rat
9. The parabrachial area: Electrophysiological evidence for an involvement in visceral nociceptive processes
10. Organization of the efferent projections from the spinal cervical enlargement to the parabrachial area and periaqueductal gray: A PHA-L study in the rat
11. Involvement of the spinoparabrachio-amygdaloid and -hypothalamic pathways in the autonomic and affective-emotional aspects of pain
12. Spino (trigemino) parabrachiohypothalamic pathway: Electrephysiological evidence for an involvement in pain processes
13. Organization of efferent projections from the parabrachial area to the hypothalamus: A Phaseolus vulgaris-leucoagglutinin study in the rat
14. Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat
15. Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: A PHA-L study in the rat
16. Physiological properties of the lamina I spinoparabrachial neurons in the rat
17. Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat
18. Involvement of the spinoparabrachial pathway in inflammatory nociceptive processes: A c-Fos protein study in the awake rat
19. Myelinated afferents signal the hyperalgesia associated with nerve injury
20. Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat?
21. Topographic organization of cardiovascular responses to electrica and glutamate microstimulation of the parabrachial nucleus in the rat
22. Differential effects of morphine along the spino-parabrachial nociceptive pathway in the rat
23. Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat
24. Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat
25. Spinal neurons specifically excited by noxious or thermal stimuli: Marginal zone of the dorsal horn
26. Central changes in primary afferent fibers following peripheral nerve lesions
27. Distribution of brainstem projections from spinal lamina I neurons in the cat and the monkey
28. An ascending general homeostatic afferent pathway originating in lamina I
29. Spinothalamic lumbosacral lamina I cells responsive to skin and muscle stimulation in the cat
30. Retrograde slowing of conduction in sensory axons central to a sciatic nerve neuroma
31. Type of sensory nerve fibre sprouting to form a neuroma
32. Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat
33. Intact sciatic myelinated primary afferent terminals collaterally sprout in the adult rat dorsal horn following section of a neighbouring peripheral nerve
34. Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in the rat
35. Topographic organization of spinal and trigeminal somatosensory pathways to the rat parabrachial and Kolliker-Fuse nuclei
36. TrkB-like immunoreactivity in rat dorsal root ganglia following sciatic nerve injury
37. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat
38. Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: Possible substrate for autonomic regulation of feeding
39. Expression of c-fos-like protein in the rat brain after injection of interleukin-1-beta into the gingiva
40. Using c-fos as a neural marker of pain
41. Morphology and dendritic domains of neurons in the lateral parabrachial nucleus of the rat
42. Subnuclear localization of FOS-like immunoreactivity in the rat parabrachial nucleus after nociceptive stimulation
43. Morphine depresses the transmission of noxious messages in the spino(trigemino)-ponto-amygdaloid pathway
44. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
45. Spinal lamina I neurons projecting to the parabrachial area of the cat midbrain
46. Physiology and morphology of the lamina I spinomesencephalic projection
47. Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons
48. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
49. Long-term effects of axotomy on beta-tubulin and NF gone expression in rat DRG neurons
50. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
51. Central sprouting and functional plasticity of regenerated primary afferents
52. Ultrastructural analysis of ectopic synaptic boutons arising from peripherally regenerated primary afferent fibers
53. Synaptic reorganization in the substantia gelatinosa after peripheral nerve neuroma formation: Aberant innervation of lamina II neurons by A beta afferents
54. Dynamic and static components of mechanical hyperalgesia in human hairy skin
55. Dynamic changes of mechanical hyperalgesia in neuropathic pain states and healthy subjects depend on the ongoing activity of unmyelinated nociceptive afterents
56. The mechanism of the pain in trigeminal neuralgia
57. Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: Indications of their place in dorsal horn functional organization
58. Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins
59. Hindbrain structures involved in pain processing as revealed by the expression of c-Fos and other immediate early gone proteins
60. Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions
61. Cutaneous sensory receptors in the rat foot
62. Physiological and morphological characteristics of spinal neurons projecting to the parabrachial region of the cat
63. Sensory dysfunction and pain after clinical nerve injury studied by means of graded mechanical and thermal stimulation
64. Sensory functions in chronic neuralgia
65. Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat
66. Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat
67. Changes in the responsiveness of parabrachial neurons in the arthritic rat: An electrophysiological study
68. Pain mechanisms: A new theory
69. Parabrachial area: Electrephysiological evidence for an involvement in cold nociception
70. Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in preicellular baskets, and in projections to deep dorsal horn and dorsal column nuclei
71. The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord
72. Changing pattern of c-FOS expression in spinal cord neurons after electrical stimulation of the chronically injured sciatic nerve in the rat
73. Distribution of c-fos expressing dorsal horn neurons after electrical stimulation of low threshold sensory fibers in the chronically injured sciatic nerve
74. Somatotopic redistribution of c-fos expressing neurons in the superficial dorsal horn after peripheral nerve injury
75. Transmission of chronic nociception by spinal neurons expressing the substance P receptor
76. Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons
77. Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation
78. Tissue acidosis in nociception and pain
79. Pain as a visceral sensation
80. Efferent connections of the parabrachial nucleus in the rat
81. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
82. The time-course of Abeta-evoked c-fos expression in neurons of the dorsal horn and gracile nucleus after peripheral nerve injury
83. Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord
84. The contribution of GABA(A) and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord
85. Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin
86. Neuronal model of tactile allodynia produced by spinal strychnine: Effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist
87. Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin
88. The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord
89. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
90. Spinal modulation of the induction of central sensitization
91. Fos expression in the medullary dorsal horn of the rat after chronic constriction injury to the infraorbital nerve
92. Evidence for a central component of post-injury pain hypersensitivity
93. The pathophysiology of chronic pain - Increased sensitivity to low threshold A beta-fibre inputs
94. The properties of neurones recorded in the superficial dorsal horn of the rat spinal cord
95. Somatotopic organization of cutaneous afferent terminals and dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord
96. Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord
97. Neuropathic pain: Aetiology, symptoms, mechanisms, and management
98. Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones
99. Peripheral nerve injury triggers central sprouting of myelinated afferents
100. Sensitization of high mechano-threshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation
101. Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy
102. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
103. Ethical guidelines for investigations of experimental pain in conscious animals