HNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex

Gene

Volumn 246, Issue 1-2, 2000, Pages 311-320

  Denson, Lee A ^a   McClure, Mitchell H ^a   Bogue, Clifford W ^a   Karpen, Saul J ^a   Jacobs, Harris C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene regulation; Liver development; Transcription factors

Indexed keywords

LUCIFERASE; NUCLEAR FACTOR I; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; DNA; DNA BINDING PROTEIN; FOXA2 PROTEIN, HUMAN; FOXA2 PROTEIN, MOUSE; FOXA2 PROTEIN, RAT; HEPATOCYTE NUCLEAR FACTOR 3BETA; HHEX PROTEIN, HUMAN; HHEX PROTEIN, MOUSE; HHEX PROTEIN, RAT; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN HEPG2; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; FIBROBLAST; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSFECTION; HOMEOBOX; HUMAN; HUMAN CELL; LIVER DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; ANIMAL; CELL CULTURE; CELL STRAIN COS1; CHEMISTRY; CYTOLOGY; DNA SEQUENCE; GENETICS; LIVER; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; PLASMID; PROTEIN BINDING; RAT; SPRAGUE DAWLEY RAT; TRANSACTIVATION;

ANIMALS; CELL LINE; COS CELLS; DNA; DNA-BINDING PROTEINS; GATA4 TRANSCRIPTION FACTOR; GENES, HOMEOBOX; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOMEODOMAIN PROTEINS; HUMANS; LIVER; LUCIFERASES; MALE; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034603621     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00082-2     Document Type: Article

References (33)

1. Ang S.L., Wierda A., Wong D., Stevens K.A., Cascio S., Rossant J., Zaret K.S. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development. 119:1993;1301-1315.
2. Arceci R.J., King A.A., Simon M.C., Orkin S.H., Wilson D.B. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol. 13:1993;2235-2246.
3. Baumhueter S., Courtois G., Morgan J.G., Crabtree G.R. The role of HNF-1 in liver-specific gene expression. Ann. N. Y. Acad. Sci. 557:1989;272-278 Ann. N. Y. Acad. Sci. 557:1989;279. discussion.
4. Baumhueter S., Courtois G., Morgan J.G., Crabtree G.R. The role of HNF-1 in liver-specific gene expression. Ann. N. Y. Acad. Sci. 557:1989;272-278 Ann. N. Y. Acad. Sci. 557:1989;279. discussion.
5. Birkenmeier E.H., Gwynn B., Howard S., Jerry J., Gordon J.I., Landschulz W.H., McKnight S.L. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev. 3:1989;1146-1156.
6. Blobel G.A., Nakajima T., Eckner R., Montminy M., Orkin S.H. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Natl. Acad. Sci. U. S. A. 95:1998;2061-2066.
7. Bossard P., Zaret K.S. GATA transcription factors as potentiators of gut endoderm differentiation. Development. 125:1998;4909-4917.
8. Cereghini S. Liver-enriched transcription factors and hepatocyte differentiation. Faseb J. 10:1996;267-282.
9. Crompton M.R., Bartlett T.J., MacGregor A.D., Manfioletti G., Buratti E., Giancotti V., Goodwin G.H. Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucleic Acids Res. 20:1992;5661-5667.
10. Denson L.A., Auld K., Schiek D., McClure M., Mangelsdorf D., Karpen S. Interleukin-1b suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. J. Biol. Chem. 375:2000;8885-8893.
11. Doll U., Niessing J. A caudal-type homeobox gene activity associated with the development and regeneration of the liver. Eur. J. Cell Biol. 70:1996;260-268.
12. Dufort D., Schwartz L., Harpal K., Rossant J. The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development. 125:1998;3015-3025.
13. Karpen S.J., Sun A.Q., Kudish B., Hagenbuch B., Meier P.J., Ananthanarayanan M., Suchy F.J. Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J. Biol. Chem. 271:1996;15 211-15 221.
14. Keng V.W., Fujimori K.E., Myint Z., Tamamaki N., Nojyo Y., Noguchi T. Expression of Hex mRNA in early murine postimplantation embryo development. FEBS Lett. 426:1998;183-186.
15. Laverriere A.C., MacNeill C., Mueller C., Poelmann R.E., Burch J.B., Evans T. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol. Chem. 269:1994;23 177-23 184.
16. Matsuda K., Kobune Y., Noda C., Ichihara A. Expression of GATA-binding transcription factors in rat hepatocytes. FEBS Lett. 353:1994;269-722.
17. Mizuguchi T., Mitaka T., Hirata K., Oda H., Mochizuki Y. Alteration of expression of liver-enriched transcription factors in the transition between growth and differentiation of primary cultured rat hepatocytes. J. Cell Physiol. 174:1998;273-284.
18. Molkentin J.D., Lin Q., Duncan S.A., Olson E.N. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11:1997;1061-1072.
19. Myint Z., Inazu T., Tanaka T., Yamada K., Keng V.W., Inoue Y., Kuriyama M., Noguchi T. Genomic organization and promoter analysis of a mouse homeobox gene, hex. J. Biochem. (Tokyo). 125:1999;795-802.
20. Overdier D.G., Porcella A., Costa R.H. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:1994;2755-2766.
21. Pani L., Quian X.B., Clevidence D., Costa R.H. The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation. Mol. Cell. Biol. 12:1992;552-562.
22. Qian X., Samadani U., Porcella A., Costa R.H. Decreased expression of hepatocyte nuclear factor 3 alpha during the acute-phase response influences transthyretin gene transcription. Mol. Cell. Biol. 15:1995;1364-1376.
23. Rausa F., Samadani U., Ye H., Lim L., Fletcher C.F., Jenkins N.A., Copeland N.G., Costa R.H. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev. Biol. 192:1997;228-246.
24. Rosenfeld M.G. POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev. 5:1991;897-907.
25. Sakai Y., Nakagawa R., Sato R., Maeda M. Selection of DNA binding sites for human transcriptional regulator GATA-6. Biochem. Biophys. Res. Commun. 250:1998;682-688.
26. Samadani U., Costa R.H. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:1996;6273-6284.
27. Tanaka T., Inazu T., Yamada K., Myint Z., Keng V.W., Inoue Y., Taniguchi N., Noguchi T. cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein. Biochem. J. 339:1999;111-117.
28. Thomas P.Q., Brown A., Beddington R.S. Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development. 125:1998;85-94.
29. Trauner M., Arrese M., Lee H., Boyer J.L., Karpen S.J. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J. Clin. Invest. 101:1998;2092-2100.
30. Xanthopoulos K.G., Mirkovitch J. Gene regulation in rodent hepatocytes during development, differentiation and disease. Eur. J. Biochem. 216:1993;353-360.
31. Xanthopoulos K.G., Prezioso V.R., Chen W.S., Sladek F.M., Cortese R., Darnell J.E. Jr. The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc. Natl. Acad. Sci. U. S. A. 88:1991;3807-3811.
32. Zaret K.S. Molecular genetics of early liver development. Annu. Rev. Physiol. 58:1996;231-251.
33. Zaret K. Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/Forkhead proteins. in process citation Dev. Biol. 209:1999;1-10.