Genomic organization and promoter analysis of a mouse homeobox gene, Hex

Journal of Biochemistry

Volumn 125, Issue 4, 1999, Pages 795-802

  Myint, Zaw ^a   Inazu, Tetsuya ^a   Tanaka, Takashi ^a   Yamada, Kazuya ^a   Keng, Vincent W ^a   Inoue, Yoshiko ^a   Kuriyama, Masaru ^a   Noguchi, Tamio ^a,b  

^a UNIVERSITY OF FUKUI   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Gene structure and regulation; Hepatocyte; Hex; Homeobox; Tissue specificity

Indexed keywords

LUCIFERASE; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL SPECIFICITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DNA FLANKING REGION; DNA TRANSFECTION; EXON; FUSION GENE; GENE STRUCTURE; HELA CELL; HOMEOBOX; HUMAN; HUMAN CELL; INTRON; LIVER CELL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REPORTER GENE; START CODON; TRANSCRIPTION REGULATION;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0032962926     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022351     Document Type: Article

References (37)

1. Levine, M. and Hoey, T. (1988) Homeobox proteins as sequence-specific transcription factors. Cell 55, 537-540
2. Gehring, W.J. (1987) Homeoboxes in the study of development. Science 236, 1245-1252
3. Chisaka, O. and Capecchi, M.R. (1991) Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350, 473-479
4. Joyner, A.L., Herrup, K., Auerbach, B.A., Davis, C.A., and Rossant, J. (1991) Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251, 1239-1243
5. Frain, M., Swart, G., Monaci, P., Nicosia, A., Stampfli, S., Frank, R., and Cortese, R. (1989) The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 59, 145-157
6. Guazzi, S., Price, M., DeFelice, M., Damante, G., Mattei, M.-G., and DiLauro, R. (1990) Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 9, 3631-3639
7. Karlsson, O., Thor, S., Norberg, T., Ohlsson, H., and Edlund, T. (1990) Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344, 879-882
8. Bedford, F.K., Ashworth, A., Enver, T., and Wiedemann, L.M. (1993) HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 21, 1245-1249
9. Crompton, M.R., Bartlett, T.J., MacGregor, A.D., Manfioletti, G., Buratti, E., Giancotti, V., and Goodwin, G.H. (1992) Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucleic Acids Res. 20, 5661-5667
10. Hromas, R., Radich, J., and Collins, S. (1993) PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells. Biochem. Biophys. Res. Commun. 195, 976-983
11. Manfioletti, G., Gattei, V., Buratti, E., Rustighi, A., De Iuliis, A., Aldinucci, D., Goodwin, G.H., and Pinto, A. (1995) Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells. Blood 85, 1237-1245
12. Keng, V.W., Fujimori, K.E., Myint, Z., Tamamaki, N., Nojyo, Y., and Noguchi, T. (1998) Expression of Hex mRNA in early murine postimplantation embryo development. FEBS Lett. 426, 183-186
13. Newman, C.S., Chia, F., and Krieg, P.A. (1997) The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Mech. Dev. 66, 83-93
14. Thomas, P.Q., Brown, A., and Beddington, R.S.P. (1998) Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 125, 85-94
15. Benton, W.D. and Davis, R.W. (1977) Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science 196, 180-182
16. Southern, E.M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503-517
17. Sanger, F., Nicklen, S., and Coulsen, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467
18. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
19. Ghosh, P.K., Reddy, V.B., Piatak, M., Lebowitz, P., and Weissman, S.M. (1980) Determination of RNA sequences by primer directed synthesis and sequencing of their cDNA transcripts. Methods Enzymol. 65, 580-595
20. Berk, A.J. and Sharp, P.A. (1977) Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. Cell 12, 721-732
21. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, pp. 1633-1636, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
22. Kunkel, T.A. (1985) Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82, 488-492
23. Sharp, P.A. (1981) Speculations on RNA splicing. Cell 23, 643-646
24. Mount, S.M. (1982) A catalogue of splice junction sequences. Nucleic Acids Res. 10, 459-472
25. Breathnach, R. and Chambon, P. (1981) Organization and expression of eukaryotic split genes coding for proteins. Annu. Rev. Biochem. 50, 349-383
26. Quandt, K., Frech, K., Karas, H., Wingender, E., and Werner, T. (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23, 4878-4884
27. Lowy, D.R. and Willumsen, B.M. (1993) Function and regulation of ras. Annu. Rev. Biochem. 62, 851-891
28. Edlund, T., Walken, M.M., Barr, P.J., and Rutter, W.J. (1985) Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science 230, 912-916
29. Widen, S.G. and Papaconstantinou, J. (1986) Liver-specific expression of the mouse alpha-fetoprotein gene is mediated by cis-acting DNA elements. Proc. Natl. Acad. Sci. USA 83, 8196-8200
30. Hagen, G., Muller, S., Beato, M., and Suske, G. (1992) Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 20, 5519-5525
31. Hagen, G., Muller, S., Beato, M., and Suske, G. (1994) Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J. 13, 3843-3851
32. Kingsley, C. and Winoto, A. (1992) Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12, 4251-4261
33. Majello, B., De Luca, P., and Lania, L. (1997) Sp3 is a bifunctional transcriptional regulator with modular independent activation and repression domains. J. Biol. Chem. 272, 4021-4026
34. Hromas, R., Collins, S.J., Hickstein, D., Raskind, W., Deaven, L.L., O'Hara, P., Hagen, F.S., and Kaushansky, K. (1991) A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J. Biol. Chem. 266, 14183-14187
35. Cereghini, S. (1996) Liver-enriched transcription factors and hepatocyte differentiation. FASEB J. 10, 267-282
36. Mitchell, P.J., Wang, C., and Tjian, R. (1987) Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell 50, 847-861
37. Santoro, C., Mermod, N., Andrews, P.C., and Tjian, R. (1988) A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature 334, 218-224