Age-related attenuation in the expression of the major heat shock proteins in human peripheral lymphocytes

Mechanisms of Ageing and Development

Volumn 107, Issue 1, 1999, Pages 105-118

  Rao, D Visala ^a   Watson, Kenneth ^a   Jones, Graham L ^a  

^a UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

Ageing; Heat shock; Heat shock proteins; Human peripheral lymphocytes

Indexed keywords

CHAPERONIN; HEAT SHOCK PROTEIN;

AGING; ARTICLE; FIBROBLAST; HUMAN; HUMAN CELL; PERIPHERAL LYMPHOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SYNTHESIS REGULATION; RECEPTOR BINDING; STRESS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; AUTORADIOGRAPHY; BLOTTING, WESTERN; CELLS, CULTURED; DENSITOMETRY; HEAT-SHOCK PROTEINS; HUMANS; LYMPHOCYTES;

EID: 0033082666     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(98)00143-2     Document Type: Article

References (41)

1. Bratton S.L., Jardine D.S., Mirkes P.E. Constitutitve synthesis of heat shock protein (72 kD) in human peripheral blood mononuclear cells: implications for use as a clinical test of recent thermal stress. Int. J. Hyperthermia. 13:1997;157-168.
2. Deguchi Y., Negoro S., Kishimoto S. Age related changes of heat shock protein gene transcription in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 157:1988;580-584.
3. Effros R.B., Zhu X., Walford R.L. Stress response of senescent T lymphocytes: Reduced hsp 70 is independent of the proliferative block. J. Geront. 49:1994;B65-B70.
4. Ellis R.J. Proteins as molecular chaperones. Nature. 328:1987;378-379.
5. Faassen A.E., O'Leary J.J., Rodysill K.J., Bergh N., Hallgren H.M. Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes from aged donors. Exp. Cell Res. 183:1989;326-334.
6. Fargnoli J., Kunisada T., Fornace A.J., Schneider E.L., Holbrook N.J. Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc. Natl. Acad. Sci. USA. 87:1990;846-850.
7. Franceschi C. et al. Successful immunosenescence and the remodelling of immune responses with ageing. Nephrol. Dial. Transplant. 11:1996;18-25.
8. Freeman B.C., Myers M.P., Schumacher R., Morimoto R.I. Identification of a regulatory motif in hsp 70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO J. 14:1995;2281-2292.
9. Gething M-J., Sambrook J. Protein folding in the cell. Nature. 355:1992;33-45.
10. Gross C., Watson K. Transcriptional and translational regulation of major heat shock proteins and patterns of trehalose mobilization during hyperthermic recovery in repressed and derepressed Saccharomyces cerevisiae. Can. J. Microbiol. 44:1998;341-350.
11. Hartl F.U. Molecular chaperones in cellular protein folding. Nature. 381:1996;571-580.
12. Heydari A.R., Takahashi R., Gutsmann A., You S., Richardson A. Hsp 70 and aging. Experientia. 50:1994;1092-1098.
13. Jones T.S., Liang A.P., Kilbourne E.M. et al. Morbidity and mortality associated with the July 1980 heat wave in St. Louis and Kansas City MO. J. Am. Med. Assoc. 247:1982;3327-3355.
14. Jurivich D.A., Qiu L., Welk J.F. Attenuated stress responses in young and old human lymphocytes. Mech. Ageing Dev. 94:1997;233-249.
15. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
16. Lindquist S., Craig E.A. The heat-shock proteins. Ann. Rev. Genet. 22:1988;631-677.
17. Liu A.Y-C., Choi H., Lee Y., Chen K.Y. Molecular events, involved in transcriptional activation of heat shock genes become progressively refractory to heat stimulation during aging of human diploid fibroblasts. J. Cell. Physiol. 149:1991;560-566.
18. Liu A.Y-C., Lin Z., Choi H., Sorhage F., Li B. Attenuated induction of heat shock gene expression in aging diploid fibroblasts. J. Biol. Chem. 264:1989;12037-12045.
19. Luce M.C., Cristofalo V.J. Reduction in heat shock gene expression correlates with increased thermosensitivity in senescent human fibroblasts. Exp. Cell Res. 202:1992;9-16.
20. Macario A.J.L. Heat-shock proteins and molecular chaperones: implications for pathogenesis; diagnostics; and therapeutics. Int. Clin. Lab. Res. 25:1995;59-70.
21. IPK; the cellular inhibitor of PKR. Proc. Natl. Acad. Sci. USA. 94:1997;97-102.
22. Minami Y., Höhfeld J., Ohtsuka K., Hartl F-U. Regulation of the heat shock protein 70 reaction cycle by the mammalian DnaJ homolog, hsp 40. J. Biol. Chem. 271:1996;19617-19624.
23. Morimoto, R.I., Tissieres, A., Georgopoulos, C. (Eds.), 1990. Stress Proteins in Biology and Medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
24. Morimoto, R.I., Tissieres, A., Georgopoulos, C. (Eds.), 1994. The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
25. Mosser D.D., Caron A.W., Bourget L., Denis-Larose C., Massie B. Role of the human heat shock protein hsp 70 in protection against stress induced apoptosis. Mol. Cell. Biol. 17:1997;5317-5327.
26. Muramatsu T., Hatoko M., Tada H., Shirai T., Ohnishi T. Age related decrease in the inductability of heat shock protein 72 in normal human skin. Br. J. Dermatol. 134:1996;1035-1038.
27. Myaishi O., Ito Y., Kozaki K-I., Sato T., Takechi H., Nagata K., Saga S. Age-related attenuation of HSP 47 heat response in fibroblasts. Mech. Ageing Dev. 77:1991;213-226.
28. Pahlavani M.A., Harris M.D., Moore S.A., Richardson A. Expression of heat shock protein 70 in rat spleen lymphocytes is affected by age but not by food restriction. J. Nutr. 126:1996;2069-2075.
29. Pahlavani M.A., Harris M.D., Moore S.A., Weindruch R., Richardson A. The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys. Exp. Cell Res. 218:1995;310-318.
30. Pawelec G., Adibzadeh M., Solana R., Beckman I. The T-cell in the ageing individual. Mech. Ageing Dev. 93:1997;35-45.
31. Polla B. A role for heat shock proteins in inflamation? Immunol. Today. 9:1988;14-137.
32. Rao, D.V., Jones, G.L., Watson, K., 1997. Heat shock protein synthesis in human lymphocytes. Proceedings of the Fifth International Federation of Teratology Societies Scientific Conference, 16-19 Nov, Sydney, Australia.
33. Samali A., Cotter T.G. Heat shock proteins increase resistance to apoptosis. Exp. Cell Res. 223:1996;163-170.
34. Sherman M.Y., Goldberg A.L. Heat shocking Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation. Nature. 357:1992;167-169.
35. Sherman M.Y., Goldberg A.L. Heat shock of Escherichia coli increases binding of dnaK (the hsp 70 homolog) to polypeptides by promoting its phosphorylation. Proc. Natl. Acad. Sci. USA. 90:1993;8452-8468.
36. Sphund S., Gershan D. Alterations in the chaperone activity of hsp 70 in aging organisms. Arch. Gerontol. 24:1997;125-131.
37. Toussaint O., Michiels C., Raes M., Remacle J. Cellular aging and the importance of energetic factors. Exp. Gerontol. 30:1995;1-22.
38. Towbin H., Stachelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
39. van Eden, W. Young, D.B. (Eds.), 1996. Stress Proteins in Medicine. Marcel Dekker, New York.
40. Watson K. Microbial stress proteins. Adv. Microbial Physiol. 31:1990;183-223.
41. Welch W.J. Mammalian stress response: Cell physiology; structure/ function of stress proteins; and implications for medicine and disease. Physiol. Rev. 72:1992;1063-1081.