Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK

Nucleic Acids Research

Volumn 28, Issue 23, 2000, Pages 4634-4641

  Turchi, J J ^a   Henkels, K M ^a   Zhou, Y ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; KU ANTIGEN; NUCLEASE; NUCLEOTIDE; OLIGONUCLEOTIDE; STREPTAVIDIN;

ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; DNA DAMAGE; DNA PROTEIN COMPLEX; DNA REPAIR; DNA STRAND BREAKAGE; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBUNIT; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN INTERACTION;

ANTIGENS, NUCLEAR; CISPLATIN; DNA; DNA ADDUCTS; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; KINETICS; MODELS, MOLECULAR; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES;

EID: 0034548910     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/28.23.4634     Document Type: Article

References (23)

1. DNA-Dependent Protein Kinase: DNA Binding and Activation in the Absence of Ku
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3. Interaction of Ku Protein and DNA-Dependent Protein Kinase Catalytic Subunit With Nucleic Acids
4. Photocross-Linking of an Oriented DNA Repair Complex - Ku Bound at a Single DNA End
5. HeLa Nuclear Protein Recognizing DNA Termini and Translocating on DNA Forming a Regular DNA-Multimeric Protein Complex
6. Analysis of the Mechanism of Interaction of Simian Ku Protein With DNA
7. The Autoantigen Ku Is Indistinguishable From NF IV, a Protein Forming Multimeric Protein-DNA Complexes
8. Geometry of a Complex Formed by Double Strand Break Repair Proteins at a Single DNA End: Recruitment of DNA-PKcs Induces Inward Translocation of Ku Protein
9. Structure of DNA-Dependent Protein Kinase: Implications for Its Regulation by DNA
10. Cisplatin, Radiation, and Adjuvant Hysterectomy Compared With Radiation and Adjuvant Hysterectomy for Bulky Stage IB Cervical Carcinoma
11. Modulation of Radiation-Induced Strand Break Repair by Cisplatin in Mammalian Cells
12. Concomitant Low Dose-Rate Irradiation and Cisplatin Treatment in Ovarian Carcinoma Cell Lines Sensitive and Resistant to Cisplatin Treatment
13. Human Ku Autoantigen Binds Cisplatin-Damaged DNA but Fails to Stimulate Human DNA-Activated Protein Kinase
14. Mechanism of DNA-Dependent Protein Kinase Inhibition by Cis-Diamminedichloroplatinum (II)-Damaged DNA
15. Cisplatin-DNA Binding Specificity of Calf High-Mobility Group 1 Protein
16. Replication Protein A (RPA) Binding to Duplex Cisplatin-Damaged DNA Is Mediated Through the Generation of Single-Stranded DNA
17. Overexpression and Purification of Human XPA Using a Baculovirus Expression System
18. DNA End-Joining Catalyzed by Human Cell-Free Extracts
19. Ku Selectively Transfers Between DNA Molecules With Homologous Ends
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21. Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini
22. Ku Proteins Join DNA Fragments As Shown by Atomic Force Microscopy
23. The DNA-Dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA