Analysis of the antigen-specific T cell response in reactive arthritis by flow cytometry

Arthritis and Rheumatism

Volumn 43, Issue 12, 2000, Pages 2834-2842

  Thiel, Andreas ^a   Wu, Peihua ^a   Lauster, Roland ^b   Braun, Jrgen ^a   Radbruch, Andreas ^b   Sieper, Joachim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b German Rheumatology Research Center   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BREFELDIN A; CD28 ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 60; INTERLEUKIN 10; INTERLEUKIN 4; OUTER MEMBRANE PROTEIN; T LYMPHOCYTE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CHLAMYDIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; PRIORITY JOURNAL; REACTIVE ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; YERSINIA;

ADULT; ANTIGENS, BACTERIAL; ARTHRITIS, REACTIVE; CHLAMYDIA; CYTOKINES; EPITOPES; FEMALE; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; SYNOVIAL FLUID; T-LYMPHOCYTES; YERSINIA;

EID: 0034538408     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200012)43:12<2834::AID-ANR25>3.0.CO;2-7     Document Type: Article

References (30)

1. Reactive arthritis
2. Identification of 2 Chlamydia trachomatis antigens recognized by synovial fluid T cells from patients with Chlamydia induced reactive arthritis
3. Identification and characterization of a DR4-restricted T cell epitope within Chlamydia heat shock protein 60
4. Report on the Fourth International Workshop on Reactive Arthritis, Berlin, Germany, July 1999
5. A single nonamer from the Yersinia 60kd heat shock protein is the target of HLA-B27 restricted CTL response in Yersinia-induced reactive arthritis
6. Characterization of the synovial T cell response to various recombinant Yersinia antigens in Yersinia enterocolitica-triggered reactive arthritis: Heat-shock protein 60 drives a major immune response
7. Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: Overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles
8. Divergent T cell cytokine patterns in arthritis
9. The elevated ratio of IFNγ/IL-4-positive T cells found in synovial fluid and synovial membrane of rheumatoid arthritis patients can be changed by IL-4 but not by IL-10 or TGFβ
10. A low secretion of tumor necrosis factor α, but no other Th1 or Th1 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis
11. Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis
12. Antigen-specific cytometry
13. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
14. T cell epitope mapping by flow cytometry
15. Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry
16. Detection of hybridomas secreting monoclonal antibodies to human gamma interferon using a rapid screening technique and specificity of certain monoclonal antibodies to gamma interferon
17. Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes
18. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
19. T cells are responsible for the enhanced synovial cellular immune response to triggering antigen in reactive arthritis
20. Bacteria-specific lymphocyte proliferation in peripheral blood in reactive arthritis and related diseases
21. Sexually acquired reactive arthritis synovial T cell clones respond to Chlamydia trachomatis 60kDa heat shock protein: Identification of CD4+ T cell epitopes
22. Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiter's syndrome are viable but show aberrant gene expression
23. Induction of HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein of Chlamydia trachomatis in human genital tract infections
24. IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection
25. IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-gamma production in NK cells and CD4+ T cells
26. Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum
27. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
28. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
29. Recent advances in the pathogenesis of reactive arthritis
30. Lack of correlation between the detection of Chlamydia trachomatis DNA in synovial fluid from patients with a range of rheumatic diseases and the presence of an antichlamydial immune response