Low secretion of tumor necrosis factor α, but no other Th1 or Th2 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis

Arthritis and Rheumatism

Volumn 42, Issue 10, 1999, Pages 2039-2044

  Braun, Jürgen ^a   Yin, Zhinan ^b   Spiller, Inge ^a   Siegert, Stefanie ^a   Rudwaleit, Martin ^a   Liu, Lanzhen ^a   Radbruch, Andreas ^a   Sieper, Joachim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA B27 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CHRONICITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PERSISTENT INFECTION; PRIORITY JOURNAL; REACTIVE ARTHRITIS; T LYMPHOCYTE SUBPOPULATION;

ADULT; ARTHRITIS, REACTIVE; BIOLOGICAL MARKERS; CHRONIC DISEASE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MONOCYTES; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033503038     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199910)42:10<2039::AID-ANR3>3.0.CO;2-6     Document Type: Article

References (20)

1. Glennås A, Kvien TK, Melby K, Øverbø A, Andrup O, Karstensen B, et al. Reactive arthritis: a favourable 2 year course and outcome, independent of triggering agent and HLA-B27. J Rheumatol 1994;21:2274-80.
2. Keat A, Thomas B, Dixey J, Osborn M, Sonnex C, Taylor Robinson D. Chlamydia trachomatis and reactive arthritis: the missing link. Lancet 1987;1:72-4.
3. Granfors K, Jalkanen S, von Essen R, Lahesmaa Rantala R, Isomaki O, Pekkola Heino K, et al. Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. N Engl J Med 1989;320:216-21.
4. Wilkinson NZ, Kingsley GH, Sieper J, Braun J, Ward ME. Lack of correlation between the detection of Chlamydia trachomatis DNA in synovial fluid from patients with a range of rheumatic diseases and the presence of an antichlamydial immune response. Arthritis Rheum 1998;41:845-54.
5. Sieper J, Kingsley G, Palacios-Boix A, Pitzalis C, Treharne J, Hughes R, et al. Synovial T lymphocyte-specific immune response to Chlamydia trachomatis in Reiter's disease. Arthritis Rheum 1991;34:588-98.
6. Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U, et al. Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum 1997;40:1788-97.
7. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
8. Assenmacher M, Schmitz J, Radbruch A. Flow cytometry determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in imterleukin-4-expressing cells. Eur J Immunol 1994;24:1097-101.
9. Sieper J, Braun J. Pathogenesis of spondylarthropathies: persistent bacterial antigen, autoimmunity, or both? Arthritis Rheum 1995; 38:1547-54.
10. Autenrieth IB, Beer M, Bohn E, Kaufmann SH, Heesemann J. Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect Immun 1994;62:2590-9.
11. Holland MJ, Bailey RL, Conway DJ, Culley F, Miranpuri G, Byrne GI, et al. T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring. Clin Exp Immunol 1996;105:429-35.
12. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-93.
13. Clerici M, Shearer GM. A Th1-Th2 switch is the critical step in the etiology of HIV infection. Immunol Today 1993;14:107-11.
14. McGuire W, Hill AVS, Allsopp CEM, Greenwood BM, Kwiatkowski D. Variation in the TNF-α promoter region associated with cerebral malaria. Nature 1994;371:508-11.
15. Westendorp RGJ, Langermans JAM, Huizinga TWJ, Elouali AH, Verweij CL, Boomsma DI, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349: 170-3.
16. Simon AK, Seipelt E, Sieper J. Divergent T-cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci U S A 1994;91: 8562-6.
17. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumour necrosis factor α promoter on transcriptional activation. Proc Natl Acad Sci U S A 1997;94:3195-9.
18. Höhler T, Schäper T, Schneider PM, Meyer zum Büschenfelde K-H, Märker-Hermann E. Association of different tumor necrosis factor α promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 1998;41:1489-92.
19. Siegert S, Yin Z, Radbruch A, Sieper J, Braun J. Evidence for a different cytokine secretion pattern of peripheral blood mononuclear cells of HLA B27+ patients with ankylosing spondylitis and HLA B27+ healthy controls compared to HLA B27-negative controls [abstract]. Arthritis Rheum 1998;41 Suppl 9:S287.
20. Leino R, Vuento R, Koskimies S, Viander M, Toivanen A. Depressed lymphocyte transformation by yersinia and E. coli in yersinia arthritis. Ann Rheum Dis 1983;42:176-81.