Influence of disease severity on nitrite and cytokine production by peripheral blood mononuclear cells (PBMC) from patients with pulmonary tuberculosis (TB)

Clinical and Experimental Immunology

Volumn 122, Issue 3, 2000, Pages 343-349

  Dlugovitzky, D ^a   Bay, M L ^a   Rateni, L ^a   Fiorenza, G ^a   Vietti, L ^a   Farroni, M A ^b   Bottasso, O A ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^b Hospital Carrasco de Rosario   (Argentina)

Author keywords

Cytokines; Disease severity; Immunoregulation; Nitrite; Tuberculosis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; NITRITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; IMMUNOREGULATION; LUNG TUBERCULOSIS; MALE; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ADOLESCENT; ADULT; AGED; CELLS, CULTURED; CYTOKINES; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; NITRITES; TRANSFORMING GROWTH FACTOR BETA; TUBERCULOSIS, PULMONARY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034535335     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01394.x     Document Type: Article

References (53)

1. Global epidemiology of tuberculosis: Morbidity and mortality of a worldwide epidemic
2. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
3. Purified protein derivative of Mycobacterium tuberculosis and excretory/secretory antigen(s) of Toxocara canis expand in vitro human T cell with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
4. In vitro synthesis of interferon-γ, interleukin-4, transforming growth factor-β, and interleukin 1-β by peripheral blood mononuclear cells from tuberculosis patients. Relationship with the severity of pulmonary involvement
5. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptative immunity
6. Functional diversity of helper T lymphocytes
7. Human endothelial cell costimulation of T cell IFN-γ production
8. Enhancement of intracellular growth of M. tuberculosis in human monocytes by transforming growth factor beta
9. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
10. Tumor necrosis factor: A pleiotropic cytokine and therapeutic target
11. Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis
12. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages
13. Mycobacterium tuberculosis (MTB)-stimulated production of nitric oxide by human alveolar macrophages and relationship of nitric oxide production to growth inhibition of MTB
14. The role of TNFα, IFNγ, TGFβ and NO in the expression of immunosuppressive functions of splenic macrophages induced by M. avium complex infection
15. The role of TGF-β in the pathogenesis of human tuberculosis
16. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection
17. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
18. Immunity to mycobacteria
19. Treatment of multidrug-resistant pulmonary tuberculosis with interferon-γ via aerosol
20. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
21. Increased expression of IL-12 receptor mRNA in active pulmonary tuberculosis and sarcoidosis
22. Expression of the IL-12 receptor β1 and β2 subunits in human tuberculosis
23. T-cell cytokine responses in human infection with Mycobacterium tuberculosis
24. Cytokine production in children with tuberculosis infection and disease
25. IFN-γ and IL-12 are increased in active compared with inactive tuberculosis
26. Absence of a prominent Th2 cytokine response in human tuberculosis
27. Increased numbers of interleukin-12-producing cells in human tuberculosis
28. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
29. Cytokine levels correlate with a radiologic score in active pulmonary tuberculosis
30. Intracellular antimicrobial activity in the absence of IFN gamma: Effect of IL-12 in experimental visceral Leishmaniasis in IFN-gamma gene-disrupted mice
31. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor β and interleukin-10
32. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls
33. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens
34. Selective deactivation of human monocyte functions by TGF-beta
35. Role of interferon-γ in counteracting the suppressive effects of transforming growth factor-β2 and glucocorticoids on the production of tumor necrosis factor-α
36. Transforming growth factor β and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype
37. On the mechanism by which transforming growth factor-β2 alters antigen-presenting abilities of macrophages on T cell activation
38. Enhanced production of TGF-β by blood monocytes from patients with active tuberculosis and presence of TGF-β in tuberculous granulomatous lung lesions
39. Cross modulation by transforming growth factor β in human tuberculosis: Suppression of antigen-driven blastogenesis and interferon γ
40. In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor β
41. Low dose TGF-β attenuates IL-12 responsiveness in murine T cells
42. Regulation of interleukin-12 by interleukin-10, transforming growth factor-β, tumor necrosis factor-α, and interferon-γ in human monocytes infected with Mycobacterium tuberculosis H37Ra
43. Recombinant tumor necrosis factor-alpha decreases whereas recombinant interleukin-6 increases growth of a virulent strain of Mycobacterium avium in human macrophages
44. Interleukin-6 antagonizes tumor necrosis factor-mediated mycobacteriostatic and mycobactericidal activities in macrophages
45. 2 by peripheral blood mononuclear cells from tuberculosis patients
46. Clinical and serological studies of tuberculosis patients receiving immunotherapy with Mycobacterium vaccae
47. Thalidomide treatment reduces tumor necrosis factor α production and enhances weight gain in patients with pulmonary tuberculosis
48. NO inhibitions: Anti-microbial properties of nitric oxide
49. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis
50. Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages
51. IFN-γ and TNT-α induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages
52. Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes
53. Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium: Killing effector mechanism depends on the generation of reactive nitrogen intermediates