Endocrine disruption: A critical review of environmental estrogens from a mechanistic perspective

Toxic Substance Mechanisms

Volumn 19, Issue 1, 2000, Pages 53-78

  Witorsch, R J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLPHENOL; ANTIANDROGEN; AROMATIC HYDROCARBON RECEPTOR; BIPHENYLDIOL; CHLORDECONE; CHLORPHENOTANE; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; LIGAND; METHOXYCHLOR; PESTICIDE; PHENOL DERIVATIVE; PHYTOESTROGEN; POLYCHLORINATED BIPHENYL; RALOXIFENE; TAMOXIFEN; UNCLASSIFIED DRUG;

CHIRALITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENDOCRINE DISEASE; ESTROGEN ACTIVITY; ESTROGEN BINDING; HUMAN; NONHUMAN; REVIEW; SCREENING TEST; SEX HORMONE DETERMINATION; SIGNAL TRANSDUCTION;

EID: 0034524675     PISSN: 10769188     EISSN: None     Source Type: Journal    
DOI: 10.1080/10769180051125752     Document Type: Review

References (108)

1. An ovarian hormone: Preliminary report on its localization, extraction and partial purification, and action in test animals
2. The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site
3. Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides
4. Synergistic activation of estrogen receptor with combinations of environmental chemicals
5. The first synthetic estrogen
6. Synergy between synthetic estrogens?
7. Lack of effect for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero
8. Risks and benefits of tamoxifen therapy
9. Targeted antiestrogens for the prevention of breast cancer
10. Use of HRT and the subsequent risk of cancer
11. Relaxin influences growth of MCF-7 cancer cells. Mitogenic and antimitogenic action depends on peptide concentration
12. Estrogenic activity of o,p'-DDT in the mammalian uterus and avian oviduct
13. Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats
14. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: Structural diversity of ligands
15. Molecular basis of agonism and antagonism in the estrogen receptor
16. Normal reproductive organ development in CF-1 mice following prenatal exposure to Bisphenol A
17. Evidence for decreasing quality of semen during past 50 years
18. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
19. Estrogen receptor-β: Implications for the prostate gland
20. A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NcoR) strongly inhibits estrogen-dependent responses in breast cancer cells
21. Interactions of gonadal steroids and pesticides (DDT, DDE) on gonaduct growth of larval tiger salamanders
22. Sex hormones and cancer-producing compounds
23. A synthetic oestrus exciting compound
24. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins
25. Effects of insulin-like growth factors (IGFs) and IGF receptor antibodies on the proliferation of human breast cancer cells
26. Synthetic oestrogenic agents without the phenanthrene nucleus
27. A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and serum lipid profile in healthy postmenopausal women
28. Molecular conformation, receptor binding, and hormone action of natural and synthetic estrogens and antiestrogens
29. Estrogenic activity of the insecticide chlordecone in the reproductive tract of birds and mammals
30. Immunolocalisation of oestrogen receptor-alpha within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood
31. Reproductive effects in birds exposed to pesticides and industrial chemicals
32. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors α and β
33. Organization versus activation: The role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife
34. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals
35. An update on estrogen receptors
36. Comparative toxicology of chloredecone (Kepone) in humans and experimental animals
37. Selective estrogen receptor modulators - A new age of estrogens in cardiovascular disease?
38. Interregional differences undermine sperm trend conclusions
39. Adenocarcinoma of the vagina; Association of maternal stilbestrol therapy with tumor appearance in young women
40. Role of tumor derived fibroblasts in the growth of primary cultures of human breast-cancer cells: Effect of epidermal growth factor and the somatostatin analogue octreotide
41. Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens
42. Interaction of human estrogen receptors alpha and beta with the same naturally occurring response elements
43. Differential regulation of gene expression by estrogenic ligands: A potential basis for the toxicity of environmental estrogens
44. An evaluation of endocrine modulators: Implications for human health
45. Commentary: Structural pervasiveness of estrogenic activity
46. An environmental antiandrogen
47. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist
48. Mutational analysis of the estrogen receptor ligand-binding domain: Influence of ligand structure and stereochemistry on transactivation
49. Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes
50. Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving
51. Comparison of the ligand specificity and transcript tissue distribution of estrogen receptors α and β
52. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
53. Pesticides: Multiple mechanisms of demasculinization
54. Influence of environmental changes on degradation of chiral pollutants in soils
55. Are the differences between estradiol and other estrogens, naturally occurring or synthetic, merely semantical?
56. Synergistic effect of environmental estrogens. Report withdrawn
57. Potency of combined estrogenic pesticides
58. Estrogenic flavonoids: Structural requirements for biologic activity
59. Association of hormone-replacement therapy with various cardiovascular risk factors in post-menopausal women. The atherosclerosis risk in communities study investigators
60. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo activity of the xenoestrogens bisphenol A and octylphenol
61. The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays. Physiology of delivery modes of estrogenic activity
62. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex
63. Peptide antagonists of the human estrogen receptor
64. Modifications of testosterone-dependent behaviors by estrogen receptor-α gene distribution in male mice
65. Debate about sperm count decline
66. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites
67. Estrogen receptor (ER) modulators each induce distinct conformational changes in ERα and ERβ
68. The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups
69. Potency of combined estrogenic pesticides
70. Additive estrogenic activities of a binary mixture of 2′,4′,6′-trichloro- and 2′,3′,4′,5′-tetrachloro-4-biphenylol
71. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: No apparent synergism
72. The relation of estrogenic activity to structure in 4,4′-dihydroxydiphenylmethanes
73. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic
74. Environmental and dietary estrogens and human health: Is there a problem?
75. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related environmental antiestrogens: Characterization and mechanism of action
76. Endocrine disruptors and human health - Is there a problem? An update
77. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression
78. Ah receptor agonists as endocrine disruptors: Antiestrogenic activity and mechanisms
79. Differential expression of estrogen receptor-β and estrogen receptor-α in the rat ovary
80. Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells in the rat testis
81. Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements
82. Another DDT connection
83. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
84. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
85. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
86. Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract
87. The E-screen assay as a tool to identify estrogens: An update on estrogenic environmental pollutants
88. Toxicity of endogenous and environmental estrogens: What is the role of elemental interactions?
89. News and comment: Environmental estrogens stir debate
90. The clinical aspects of estrogen and the cardiovascular system
91. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment
92. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β
93. Have sperm densities declined? A reanalysis of global trend data
94. Response: A reanalysis of sperm density data
95. Structural requirements of para-alkylphenols to bind to estrogen receptor
96. Relationship of growth stimulated by lithium, estradiol, and EGF to phospholipase C activity in MCF-7 human breast cancer cells
97. Editorial
98. Animals as sentinels of human health hazards of environmental chemicals
99. Ontogeny of estrogen receptor-β expression in rat testis
100. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses
101. A molecular modeling analysis of diethylstilbestrol conformations and their similarity to estradiol-17β
102. Comparative analyses of mechanistic differences among antiestrogens
103. Environmental organochlorine exposure as a potential etiologic factor in breast cancer
104. Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2′-bis(p-chlorophenyl) ethylene