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Volumn 16, Issue 3, 1996, Pages 277-285

Mutational analysis of the estrogen receptor ligand-binding domain: Influence of ligand structure and stereochemistry on transactivation

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLSTILBESTROL DERIVATIVE; ESTROGEN RECEPTOR; HISTIDINE; INDENESTROL A; LIGAND; METHIONINE; VALINE;

EID: 0029895333     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0160277     Document Type: Article
Times cited : (16)

References (43)
  • 1
    • 0021864852 scopus 로고
    • Diethyl pyrocarbonate, a histidine selective reagent, inhibits estrogen binding to receptor protein in rat uterus cytosol
    • Baker ME, Sklar DH, Terry LS & Hedges MR 1985 Diethyl pyrocarbonate, a histidine selective reagent, inhibits estrogen binding to receptor protein in rat uterus cytosol. Biochemistry International 11 233-238.
    • (1985) Biochemistry International , vol.11 , pp. 233-238
    • Baker, M.E.1    Sklar, D.H.2    Terry, L.S.3    Hedges, M.R.4
  • 2
    • 0027521287 scopus 로고
    • Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
    • Beekman JM, Allan GF, Tsai SY, Tsai M-J & O'Malley BW 1993 Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Molecular Endocrinology 7 1266-1274.
    • (1993) Molecular Endocrinology , vol.7 , pp. 1266-1274
    • Beekman, J.M.1    Allan, G.F.2    Tsai, S.Y.3    Tsai, M.-J.4    O'Malley, B.W.5
  • 3
    • 0029012163 scopus 로고
    • Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
    • Bourguet W, Ruff M, Chambon P, Gronemeyer H & Moras D 1995 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375 377-382.
    • (1995) Nature , vol.375 , pp. 377-382
    • Bourguet, W.1    Ruff, M.2    Chambon, P.3    Gronemeyer, H.4    Moras, D.5
  • 4
    • 0025789760 scopus 로고
    • Estrogen receptor stereochemistry: Ligand binding orientation and influence on biological activity
    • Chae K, Gibson M & Korach K 1991 Estrogen receptor stereochemistry: ligand binding orientation and influence on biological activity. Molecular Pharmacology 40 806-811.
    • (1991) Molecular Pharmacology , vol.40 , pp. 806-811
    • Chae, K.1    Gibson, M.2    Korach, K.3
  • 5
    • 0025267297 scopus 로고
    • Uterine estrogen receptor interaction with estrogen-responsive DNA sequences in vitro: Effects of ligand binding on receptor-DKA complexes
    • Curtis SW & Korach KS 1990 Uterine estrogen receptor interaction with estrogen-responsive DNA sequences in vitro: effects of ligand binding on receptor-DKA complexes. Molecular Endocrinolgy 4 276-286.
    • (1990) Molecular Endocrinolgy , vol.4 , pp. 276-286
    • Curtis, S.W.1    Korach, K.S.2
  • 6
    • 0027464805 scopus 로고
    • Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen
    • Danielian PS, White R, Hoare SA, Fawell SE & Parker MG 1993 Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen. Molecular Endocrinology 7 232-240.
    • (1993) Molecular Endocrinology , vol.7 , pp. 232-240
    • Danielian, P.S.1    White, R.2    Hoare, S.A.3    Fawell, S.E.4    Parker, M.G.5
  • 7
    • 0019725582 scopus 로고
    • Molecular details of receptor binding and hormonal action of steroids derived from X-ray crystallographic investigations
    • Duax WL, Griffen JF, Roher DC. Swenson DC & Weeks CM 1981 Molecular details of receptor binding and hormonal action of steroids derived from X-ray crystallographic investigations. Journal of Steroid Biochemistry 15 41-47
    • (1981) Journal of Steroid Biochemistry , vol.15 , pp. 41-47
    • Duax, W.L.1    Griffen, J.F.2    Roher, D.C.3    Swenson, D.C.4    Weeks, C.M.5
  • 8
    • 0025329841 scopus 로고
    • Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
    • Fawell JA, Lees JA, White R & Parker MG 1990 Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell 60 953-962.
    • (1990) Cell , vol.60 , pp. 953-962
    • Fawell, J.A.1    Lees, J.A.2    White, R.3    Parker, M.G.4
  • 9
    • 0022899142 scopus 로고
    • Computer modeling of estradiol with the estrogen receptor
    • Gordon MS & Notides AC 1986 Computer modeling of estradiol with the estrogen receptor. Journal of Steroid Biochemistry 25 177-181.
    • (1986) Journal of Steroid Biochemistry , vol.25 , pp. 177-181
    • Gordon, M.S.1    Notides, A.C.2
  • 10
    • 0020645052 scopus 로고
    • Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast
    • Guarente L 1983 Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. Methods In Enzymology 101 181-191.
    • (1983) Methods in Enzymology , vol.101 , pp. 181-191
    • Guarente, L.1
  • 11
    • 0024330337 scopus 로고
    • Identification of cysteine 530 as the covalent attachment site of an affinity-labeling estrogen (ketonoestrol azindine) and antiestrogen (tamoxifen azindine) in the human estrogen receptor
    • Harlow KW. Smith DX, Katzenellenbogen JA, Greene GL & Katzenellenbogen BS 1989 Identification of cysteine 530 as the covalent attachment site of an affinity-labeling estrogen (ketonoestrol azindine) and antiestrogen (tamoxifen azindine) in the human estrogen receptor. Journal of Biological Chemistry 264 17476-17485.
    • (1989) Journal of Biological Chemistry , vol.264 , pp. 17476-17485
    • Harlow, K.W.1    Smith, D.X.2    Katzenellenbogen, J.A.3    Greene, G.L.4    Katzenellenbogen, B.S.5
  • 13
    • 0025242415 scopus 로고
    • Endocrine pharmacology of antiestrogens as antitumor agents
    • Jordan VC & Murphy CS 1990 Endocrine pharmacology of antiestrogens as antitumor agents. Endocrine Reviews 11 578-610.
    • (1990) Endocrine Reviews , vol.11 , pp. 578-610
    • Jordan, V.C.1    Murphy, C.S.2
  • 14
    • 0024296177 scopus 로고
    • A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor
    • Klein-Hitpass L, Ryffel GU, Heitlinger E & Cato AC 1988 A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Research 16 647-663.
    • (1988) Nucleic Acids Research , vol.16 , pp. 647-663
    • Klein-Hitpass, L.1    Ryffel, G.U.2    Heitlinger, E.3    Cato, A.C.4
  • 16
    • 0018773081 scopus 로고
    • Estrogen action in the mouse uterus: Characterization of cytosol and nuclear receptor systems
    • Korach KS 1979 Estrogen action in the mouse uterus: characterization of cytosol and nuclear receptor systems. Endocrinology 104 1324-1332.
    • (1979) Endocrinology , vol.104 , pp. 1324-1332
    • Korach, K.S.1
  • 17
    • 8244254178 scopus 로고
    • Stilbestrol estrogens: Molecular/structural probes for understanding estrogen action
    • Eds M Bohl & W Duax. Boca Raton: CRC Press Inc.
    • Korach KS 1992 Stilbestrol estrogens: molecular/structural probes for understanding estrogen action. In Molecular Structure and Biological Activity of Steroids, pp 209-227. Eds M Bohl & W Duax. Boca Raton: CRC Press Inc.
    • (1992) Molecular Structure and Biological Activity of Steroids , pp. 209-227
    • Korach, K.S.1
  • 19
    • 0018733151 scopus 로고
    • Diethylstilbestrol metabolites and analogs: New probes for the study of hormone action
    • Korach KS, Metzler M & McLachlan JA 1979 Diethylstilbestrol metabolites and analogs: new probes for the study of hormone action. Journal of Biological Chemistry 254 8963-8968.
    • (1979) Journal of Biological Chemistry , vol.254 , pp. 8963-8968
    • Korach, K.S.1    Metzler, M.2    McLachlan, J.A.3
  • 20
    • 0022381978 scopus 로고
    • Diethylstilbestrol metabolites and analogs: Biochemical probes for differential stimulation of uterine estrogen responses
    • Korach KS, Fox-Davies C, Quarmby VE & Swaisgood MH 1985 Diethylstilbestrol metabolites and analogs: biochemical probes for differential stimulation of uterine estrogen responses. Journal of Biological Chemistry 260 15420-15426
    • (1985) Journal of Biological Chemistry , vol.260 , pp. 15420-15426
    • Korach, K.S.1    Fox-Davies, C.2    Quarmby, V.E.3    Swaisgood, M.H.4
  • 21
    • 0023554425 scopus 로고
    • Estrogen receptor stereochemistry: Receptor binding and hormonal responses
    • Korach KS, Levy LA & Sarver PJ 1987 Estrogen receptor stereochemistry: receptor binding and hormonal responses. Journal of Steroid Biochemistry 27 281-290.
    • (1987) Journal of Steroid Biochemistry , vol.27 , pp. 281-290
    • Korach, K.S.1    Levy, L.A.2    Sarver, P.J.3
  • 22
    • 0024584317 scopus 로고
    • Diethylstilbestrol metabolites and analogs: Stereochemical probes for the estrogen receptor binding site
    • Korach KS, Chae K, Levy LA, Duax WL & Sarver PJ 1989 Diethylstilbestrol metabolites and analogs: stereochemical probes for the estrogen receptor binding site. Journal of Biological Chemistry 264 5642-5647.
    • (1989) Journal of Biological Chemistry , vol.264 , pp. 5642-5647
    • Korach, K.S.1    Chae, K.2    Levy, L.A.3    Duax, W.L.4    Sarver, P.J.5
  • 23
    • 0025896525 scopus 로고
    • Estrogen receptor stereochemistry: Ligand binding and hormonal responsiveness
    • Korach KS, Chae K, Gibson M & Curtis S 1991 Estrogen receptor stereochemistry: ligand binding and hormonal responsiveness. Steroids 56 263-270.
    • (1991) Steroids , vol.56 , pp. 263-270
    • Korach, K.S.1    Chae, K.2    Gibson, M.3    Curtis, S.4
  • 24
    • 0022773520 scopus 로고
    • Localization of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor
    • Kumar V, Green S, Staub A & Chambon P 1986 Localization of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. EMBO Journal 5 2231-2236.
    • (1986) EMBO Journal , vol.5 , pp. 2231-2236
    • Kumar, V.1    Green, S.2    Staub, A.3    Chambon, P.4
  • 26
    • 0024318808 scopus 로고
    • Identification of two transactivation domains in the mouse oestrogen receptor
    • Lees JA, Fawell SE & Parker MG 1989 Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Research 17 5477-5488
    • (1989) Nucleic Acids Research , vol.17 , pp. 5477-5488
    • Lees, J.A.1    Fawell, S.E.2    Parker, M.G.3
  • 28
  • 31
    • 0023895442 scopus 로고
    • The human oestrogen receptor functions in yeast
    • Metzger D, White JH & Chambon P 1988 The human oestrogen receptor functions in yeast. Nature 334 31-36.
    • (1988) Nature , vol.334 , pp. 31-36
    • Metzger, D.1    White, J.H.2    Chambon, P.3
  • 32
    • 0023009068 scopus 로고
    • Inhibition of restriction endonuclease NciI cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis
    • Nakamaye K & Eckstein F 1986 Inhibition of restriction endonuclease NciI cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis. Nucleic Acids Research 14 9679-9689.
    • (1986) Nucleic Acids Research , vol.14 , pp. 9679-9689
    • Nakamaye, K.1    Eckstein, F.2
  • 34
    • 0026744710 scopus 로고
    • Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination
    • Pakdel F & Katzenellenbogen BS 1992 Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination. Journal of Biological Chemistry 267 3429-3437.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 3429-3437
    • Pakdel, F.1    Katzenellenbogen, B.S.2
  • 35
    • 0022421656 scopus 로고
    • Separation and detection of enantiomers of stilbestrol analogues by combined high-performance liquid chromatography-thermospray mass spectrometry
    • Parker CE, Levy LA, Smith RW, Yarnaguchi K, Gaskel SJ & Korach KS 1985 Separation and detection of enantiomers of stilbestrol analogues by combined high-performance liquid chromatography-thermospray mass spectrometry. Journal of Chromatography 344 378-384.
    • (1985) Journal of Chromatography , vol.344 , pp. 378-384
    • Parker, C.E.1    Levy, L.A.2    Smith, R.W.3    Yarnaguchi, K.4    Gaskel, S.J.5    Korach, K.S.6
  • 36
    • 0023792645 scopus 로고
    • Mammalian glucocorticoid receptor derivatives enhance transcription in yeast
    • Shena M & Yamamoto KR 1988 Mammalian glucocorticoid receptor derivatives enhance transcription in yeast. Science 241 965-967.
    • (1988) Science , vol.241 , pp. 965-967
    • Shena, M.1    Yamamoto, K.R.2
  • 37
    • 0026030413 scopus 로고
    • New vectors for constitutive and inducible gene expression in yeast
    • Shena M, Picard D & Yamamoto KR 1990 New vectors for constitutive and inducible gene expression in yeast. Methods in Enzymology 194 389-398.
    • (1990) Methods in Enzymology , vol.194 , pp. 389-398
    • Shena, M.1    Picard, D.2    Yamamoto, K.R.3
  • 38
    • 0024553005 scopus 로고
    • Effect of the substitution Ala-Gly at each of five residue positions in the C-peptide helix
    • Strehlow KG & Baldwin RL 1989 Effect of the substitution Ala-Gly at each of five residue positions in the C-peptide helix. Biochemistry 28 2130-2133.
    • (1989) Biochemistry , vol.28 , pp. 2130-2133
    • Strehlow, K.G.1    Baldwin, R.L.2
  • 39
    • 0028786569 scopus 로고
    • Yeast two-hybrid system demonstrates that estrogen receptor dimerization is ligand-dependent in vivo
    • Wang H, Peters GA, Zeng X, Tang M, Ip W & Khan SA 1995 Yeast two-hybrid system demonstrates that estrogen receptor dimerization is ligand-dependent in vivo. Journal of Biological Chemistry 270 23322-23329.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 23322-23329
    • Wang, H.1    Peters, G.A.2    Zeng, X.3    Tang, M.4    Ip, W.5    Khan, S.A.6
  • 40
    • 0023628759 scopus 로고
    • Structural organization and expression of the mouse estrogen receptor
    • White R, Lees JA. Needham M & Parker M 1987 Structural organization and expression of the mouse estrogen receptor. Molecular Endocrinology 1 735-744.
    • (1987) Molecular Endocrinology , vol.1 , pp. 735-744
    • White, R.1    Lees, J.A.2    Needham, M.3    Parker, M.4
  • 41
    • 0025168330 scopus 로고
    • Ligand-specific activation of gene expression by a derivative of the human glucocorticoid receptor expressed in yeast
    • Wright APH, Carlstedt-Duke J & Gustafsson J-A 1990 Ligand-specific activation of gene expression by a derivative of the human glucocorticoid receptor expressed in yeast. Journal of Biological Chemistry 265 14763-14769.
    • (1990) Journal of Biological Chemistry , vol.265 , pp. 14763-14769
    • Wright, A.P.H.1    Carlstedt-Duke, J.2    Gustafsson, J.-A.3
  • 42
    • 0021710272 scopus 로고
    • Use of lacZ fusions to delimit regulatory elements of inducible divergent Gall-Cal 10 promoter in S. cerevisiae
    • Yocum RR, Hanley S, West Jr RW & Ptashne M 1984 Use of lacZ fusions to delimit regulatory elements of inducible divergent Gall-Cal 10 promoter in S. cerevisiae. Molecular and Cellular Biology 4 1985-1998.
    • (1984) Molecular and Cellular Biology , vol.4 , pp. 1985-1998
    • Yocum, R.R.1    Hanley, S.2    West Jr., R.W.3    Ptashne, M.4
  • 43
    • 0027048595 scopus 로고
    • Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors
    • Yoshmaga SK, Peterson CL, Herskowitz I & Yamamoto KR 1992 Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors Science 258 1598-1603.
    • (1992) Science , vol.258 , pp. 1598-1603
    • Yoshmaga, S.K.1    Peterson, C.L.2    Herskowitz, I.3    Yamamoto, K.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.