Apoptosis induced by 1′-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation

Carcinogenesis

Volumn 21, Issue 12, 2000, Pages 2151-2157

  Moffatt, Jerry ^a   Hashimoto, Makiko ^a   Kojima, Akiko ^a   Kennedy, David Opare ^a   Murakami, Akira ^b   Koshimizu, Koichi ^b   Ohigashi, Hajime ^c   Matsui Yuasa, Isao ^a  

^a Osaka Prefecture University   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1' ACETOXYCHAVICOL ACETATE; ACYLTRANSFERASE; AMINO ACID; ANTINEOPLASTIC AGENT; CASPASE 3; DNA FRAGMENT; ENZYME INHIBITOR; GAMMA INTERFERON; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NATURAL PRODUCT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; ORNITHINE DECARBOXYLASE; ORNITHINE DECARBOXYLASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; POLYAMINE DERIVATIVE; PROTEINASE; PURINE; PUTRESCINE; REACTIVE OXYGEN METABOLITE; SPERMIDINE; SPERMINE; SUPEROXIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL MEMBRANE; CELL NUCLEUS; CELL SIZE; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG EFFICACY; EHRLICH ASCITES TUMOR CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; POLYAMINE METABOLISM; PRIORITY JOURNAL;

EID: 0034523991     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.12.2151     Document Type: Article

References (50)

1. A potent inhibitor of tumor promoter-induced Epstein-Barr virus activation, 1′-acetoxychavicol acetate from Languas galanga, a traditional Thai condiment
2. Inhibitors of xanthine oxidase from Alpinia galanga
3. 1′-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin
4. Chemopreventive effect of a xanthine oxidase inhibitor, 1′-acetoxychavicol acetate, on rat oral carcinogenesis
5. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine inhibitor, 1′-acetoxychavicol acetate
6. A xanthine oxidase inhibitor 1′-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats
7. Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1′-acetoxychavicol acetate
8. Prevention by 1′-acetoxychavicol of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid defined diet
9. Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1′-acetoxychavicol acetate
10. Inhibition by 1′-acetoxychavicol acetate of lipopolysaccharide- and interferon-γ-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW 264 cells
11. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy
12. Polyamines
13. Polyamine metabolism and function
14. 1-acetyltransferase, the turning point in polyamine metabolism
15. Polyamines as target for therapeutic invention
16. Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells
17. Properties of spermine N-acetyltransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermine into putrescine
18. Apoptosis of interleukin-2-dependent mouse T cell line by protein tyrosine phosphorylation and polyamines
19. Is polyamine decrease a common feature of apoptosis? Evidence from gamma ray- and heat shock-induced cell death
20. Different prooxidant levels stimulate growth, trigger apoptosis or produce necrosis of insulin secreting RINm5F cells. The role of intracellular polyamines
21. Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells
22. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis
23. Molecular and cellular functions of polyamines
24. Modulation of antineoplastic drug action by inhibitors of polyamine synthesis
25. Apoptosis: The molecular basis of cell death
26. Caspases: Enemies within
27. Caspases: The executioners of apoptosis
28. Control by hyperthemia of ornithine decarboxylase in Ehrlich ascites tumor cells
29. A rapid and sensitive method for the quantities of protein utilizing the principle of protein-dye binding
30. 1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells
31. Determination of nucleic acids in tissues by pentose analysis
32. Neutral red assay for cell viability and xenobiotic-induced cytotoxicity in primary cultures of human and rat hepatocytes
33. Resistance of aberrant crypt foci to apoptosis induced by azoxymethane in rats chronically fed cholic acid diet
34. Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: Effects on esophageal cell proliferation and apoptosis
35. P44/42 mitogen activated protein kinase is involved in the expression of ornithine decarboxylase in leukemia L1210 cells
36. Effects of antioxidants on ornithine decarboxylase in mitogenically-activated T lymphocytes
37. 11-bis(ethyl)norspermine
38. 1-acetyltransferase stably expressed in Chinese hamster ovary cells
39. The role of polyamine catabolism in polyamine analogue-induced programme cell death
40. 1-acetyltransferase by polyamines
41. Spermine prevents endonuclease activation and apoptosis in thymocyte
42. Induction of apoptotic cell death in three human osteosarcoma cell lines by polyamine synthesis inhibitor, methylglyoxal bis(cyclopentyl-amidinohydrazone) (MGBCP)
43. Effects of methylacetylenic putrescine, an ornithine decarboxylase inhibitor and potential novel anticancer agent on human and mouse cancer cell lines
44. Polyamine acetylation and apoptosis
45. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
46. A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD
47. Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in bcl-2-overproducing cells
48. Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons
49. Resistance of Ehrlich tumor cells to apoptosis can be due to accumulation of heat shock proteins
50. Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by Melphalan (L-phenylalanine mustard) in human colorectal cancer cells