Structure and regulation of L-type calcium channels: A current assessment of the properties and roles of channel subunits

Trends in Cardiovascular Medicine

Volumn 6, Issue 8, 1996, Pages 265-273

  Hosey, M Marlene ^a   Chien, Andy J ^a   Puri, Tipu S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL;

ARTICLE; CALCIUM CURRENT; CHANNEL GATING; ENZYME SUBUNIT; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0030480470     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(96)00109-0     Document Type: Review

References (58)

1. Beam KG, Adams BA, Niidome T, Numa S, Tanabe T: 1992. Function of a truncated dihydropyridine receptor as both voltage sensor and calcium channel. Nature 360:169-171.
2. Birnbaumer L, Campbell KP, Catterall WA, et al.: 1994. The naming of voltage-gated calcium channels. Neuron 13:505-506.
3. 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel. J Biol Chem 267:18,218-18,223.
4. 2+ channel β-subunits. Biochem Soc Trans 22:483-488.
5. Catterall WA: 1995. Structure and function of voltage-gated ion channels. Annu Rev Biochem 64:493-531.
6. Chang FC, Hosey MM: 1988. Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different. J Biol Chem 263:18,929-18,937.
7. Chang CF, Gutierrez LM, Mundina-Weilenmann C, Hosey MM: 1991. Dihydropyridine-sensitive calcium channels from skeletal muscle. II. Functional effects of differential phosphorylation of channel subunits. J Biol Chem 266:16,395-16,400.
8. 2+ channels. J Biol Chem 270:30,036-30,044.
9. 2α subunit and effects on channel function. J Biol Chem 271:26465-26469.
10. De Jongh KS, Warner C, Colvin AA, Catterall WA: 1991. Characterization of the two size forms of the alpha 1 subunit of skeletal muscle L-type calcium channels. Proc Natl Acad Sci USA 88:10,778-10,782.
11. De Waard M, Gurnett CA, Campbell KP: 1996. Structural and functional diversity of voltage-activated calcium channels. In Narahashi T, ed. Ion Channels. New York, Plenum Press, pp 41-87.
12. 1A. J Biol Chem 271:11,745-11,749.
13. 2δ subunit of a calcium channel. J Biol Chem 271:5768-5776.
14. George AL: 1995. Molecular genetics of ion channel diseases. Kidney Int 48:1180-1190.
15. Gerhardstein B, Puri TS, Zhao X-L, Hosey MM: 1996. In vitro phosphorylation of subunits of cardiac L-type Ca channels by protein kinase A and protein kinase C [abst]. Biophys J 70: A186.
16. Grabner M, Wang Z, Hering S, Striessnig J, Glossman H: 1996. Transfer of 1, 4-dihydropyridine sensitivity from L-type to class A (B1) calcium channels. Neuron 16:207-218.
17. 2δ subunit in current stimulation and subunit interaction. Neuron 16:431-440.
18. 1-subunit. Biochem Biophys Res Commun 202:857-865.
19. Haase H, Karczewski P, Beckert R, Krause EG: 1993. Phosphorylation of the L-type calcium channel beta subunit is involved in beta-adrenergic signal transduction in canine myocardium. FEBS Lett 335:217-222.
20. Hell JW, Westenbroek RE, Breeze LJ, Wang KKW, Chavkin C, Catterall WA: 1996. N-Methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proc Natl Acad Sci USA 93:3362-3367.
21. Hockerman GH, Johnson BD, Scheuer T, Catterall WA: 1995. Molecular determinants of high affinity block of L-type calcium channels by phenylalkylamines. J Biol Chem 270: 22,119-22,122.
22. Huang JM, Xian H, Bacaner M: 1992. Long-chain fatty acids activate calcium channels in ventricular myocytes. Proc Natl Acad Sci USA 89:6452-6456.
23. Jay SD, Ellis SB, McCue AF, et al.: 1990. Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle. Science 248:490-492.
24. 2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase. Proc Natl Acad Sci USA 91:11,492-11,496.
25. Josephson IR, Varadi G: 1996. The subunit increases Ca currents and gating charge movements of human cardiac L-type Ca channels. Biophys J 70:1285-1293.
26. Juntti-Berggren L, Larsson O, Rorsman P, et al.: 1993. Increased activity of L-type calcium channels exposed to serum from patients with type I diabetes. Science 261:86-90.
27. 1 subunits of L-type calcium channels in rat skeletal muscle cell. J Biol Chem 265:20,839-20,848.
28. Lang B, Newsom-Davis J: 1995. Immunopathology of the Lambert-Eaton myasthenic syndrome. Springer Semin Immunopathol 17:3-15.
29. Lehmann-Horn F, Rudel R: 1995. Hereditary nondystrophic myotonias and periodic paralyses. Curr Opin Neurol 8:402-410.
30. Lipton SA: 1994. AIDS-related dementia and calcium homeostasis. Ann NY Acad Sci 747: 205-224.
31. Ma J, Gutierrez LM, Hosey MM, Rios E: 1992. Dihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. Part 3: Effects of phosphorylation by protein kinase C. Biophys J 63:39-647.
32. McDonald TF, Pelzer S, Trautwein W, Pelzer DJ: 1994. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74:365-507.
33. 1-subunits by site directed mutagenesis [abst]. Biophys J 70:A187.
34. 2+ currents in a motoneuron cell line. Ann Neurol 37:102-109.
35. Mundina-Weilenmann C, Chang CF, Gutierrez LM, Hosey MM: 1991a. Demonstration of the phosphorylation of dihydropyridine-sensitive calcium channels in chick skeletal muscle and the resultant activation of the channels after reconstitution. J Biol Chem 266:4067-4073.
36. Mundina-Weilenmann C, Ma J, Rios E, Hosey MM: 1991b. Dihydropyridine-sensitive skeletal muscle Ca channels in polarized planar bilayers. II. Effects of phosphorylation by cAMP-dependent protein kinase. Biophys J 60:902-909.
37. Neely A, Wei X, Olcese R, Birnbaumer L, Stefani E: 1993. Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel. Science 262:575-578.
38. Olcese R, Qin N, Schneider T, et al: 1994. The amino terminus of a calcium channel β subunit sets rates of inactivation independently of the subunit's effect on activation. Neuron 13:1433-1438.
39. 1E [abst]. Biophys J 70:A184.
40. Orlov SN, Li JM, Tremblay J, Hamet P: 1995. Genes of intracellular calcium metabolism and blood pressure control in primary hypertension. Semin Nephrol 15:569-592.
41. 1C subunit. FEBS Lett 384: 189-192.
42. Perez-Garcia MT, Kamp TJ, Marban E: 1995. Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells: roles of alpha 1 and beta subunits. J Gen Physiol 105:289-305.
43. 2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location. J Biol Chem 268:9275-9279.
44. Rotman EI, De Jongh KS, Florio V, Lai Y, Catterall WA: 1992. Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase. J Biol Chem 267:16,100-16,105.
45. Rotman EI, Murphy BJ, Catterall WA: 1995. Sites of selective cAMP-dependent phosphorylation of the L-type calcium channel alpha 1 subunit from intact rabbit skeletal muscle myotubes. J Biol Chem 270:16,371-16,377.
46. Roux MJ, Tareilus E, Qin N, Birnbaumer L, Stefani E: 1996. Molecular cloning of a functional Xenopus oocyte calcium channel β subunit [abst]. Biophys J 70:A317.
47. Scott VES, De Waard M, Liu H, et al.: 1996. β-Subunit heterogeneity in N-type Ca channels. J Biol Chem 271:3207-3217.
48. + channel surface expression through effects early in biosynthesis. Neuron 16:843-852.
49. 2+ current enhancement by alpha 2/delta and beta subunits in Xenopus oocytes: contribution of changes in channel gating and alpha 1 protein level. J Physiol 489:55-62.
50. Shulman D, Levinson SR, Chaudhari N, Beam K: 1996. The full-length isoform of the alpha1 subunit of the skeletal muscle calcium channel is present in the sarcolemma and declines in abundance during development [abst]. Biophys J 70:A183.
51. Singer-Lahat D, Lotan I, Biel M, Flockerzi V, Hofmann F, Dascal N: 1994. Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation. Receptors Channels 2:215-226.
52. 2+ channel splice variants. J Biol Chem 270:10,540-10,543.
53. 2+ channel complex purified from brain. Science 261:486-489.
54. Yamada Y, Masuda K, Li Q, et al.: 1995. The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. Genomics 27:312-319.
55. 2+ channels with beta 1-adrenoceptors. Circ Res 76:335-342.
56. Yoshida A, Takahashi M, Nishimura S, Takeshima H, Kokubun S: 1992. Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel. FEBS Lett 309:343-349.
57. Zhao XL, Gutierrez LM, Chang CF, Hosey MM: 1994. The alpha 1-subunit of skeletal muscle L-type Ca channels is the key target for regulation by A-kinase and protein phosphatase-1C. Biochem Biophys Res Commun 198:166-173.
58. Zong X, Schreieck J, Mehrke G, et al.: 1995. On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation. Pflügers Arch 430:340-347.