Inhibition of IgE-dependent histamine release from human peripheral blood basophils by humanized Fab fragments that recognize the membrane proximal domain of the human FcεRI α-chain

International Archives of Allergy and Immunology

Volumn 123, Issue 4, 2000, Pages 308-318

  Takai, Toshiro ^a,b   Yuuki, Toshifumi ^b   Ra, Chisei ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ASAHI BREWERIES LTD   (Japan)

Author keywords

Allergy; CDR grafting; Degranulation; Fab fragments; High affinity IgE receptor; Humanized antibody; IgE; IgE network

Indexed keywords

AMINO ACID; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CRA2; MONOCLONAL ANTIBODY CRA4; UNCLASSIFIED DRUG;

ALLERGY; ALPHA CHAIN; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BASOPHIL; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CROSS LINKING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE LOCUS; HISTAMINE RELEASE; HUMAN; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; BASOPHILS; HISTAMINE RELEASE; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, IGE; RECOMBINANT FUSION PROTEINS;

EID: 0034515128     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053643     Document Type: Article

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