Dictyostelium discoideum: A model system for differentiation and patterning

International Journal of Developmental Biology

Volumn 44, Issue 8, 2000, Pages 819-835

  Escalante, R ^a   Vicente, J J ^a  

^a CSIC   (Spain)

Author keywords

Aggregation; Culmination; Dictyostelium discoideum; Differentiation; Signal transduction pathways; Slug migration; Sporulation

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE;

CELL DIFFERENTIATION; CHEMOTAXIS; DICTYOSTELIUM DISCOIDEUM; EXPRESSED SEQUENCE TAG; GENE DISRUPTION; GENE EXPRESSION REGULATION; MOLECULAR DYNAMICS; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SPOROGENESIS;

ANIMALS; BODY PATTERNING; CELL DIFFERENTIATION; CHEMOTAXIS; DICTYOSTELIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TIME FACTORS;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; FUNGI; GASTROPODA;

EID: 0034495874     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (170)

1. Isolation of Dictyostelium discoideum cytokinesis mutants by restriction enzyme-mediated integration of the Blasticidin S resistance marker
2. The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
3. Discoidin proteins of Dictyostelium are necessary for normal cytoskeletal organization and cellular morphology during aggregation
4. Production and activity of spore differentiation factors (SDFs) in Dictyostelium
5. Overexpression of DdPK2 protein kinase causes rapid development and affects the intracellular cAMP pathway of Dictyostelium discoideum
6. Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum
7. Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor
8. Serum response factor is essential for mesoderm formation during mouse embryogenesis
9. Spalten, a protein containing G alpha-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium
10. Origin and evolution of the slime molds (Mycetozoa)
11. Cyclic AMP is an inhibitor of stalk cell differentiation in Dictyostelium discoideum
12. Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum
13. Diffusible signal molecules controlling cell differentiation and patterning in Dictyostelium
14. Efficient control of gene expression by a tetracycline-dependent transactivator in single Dictyostelium discoideum cells
15. Phospholipase C in Dictyostelium discoideum - Identification of stimulatory and inhibitory surface receptors and G-proteins
16. Cell density sensing mediated by a G protein-coupled receptor activating phospholipase C
17. Dictyostelium mucoroides. Ein neuer Organismus aus der Verwandtschaft der Myxomyceten. Abhandlungen der Senckenbergischen
18. A cell-counting factor regulating structure size in Dictyostelium
19. A Dictyostelium mutant with defective aggregate size determination
20. Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in Dictyostelium
21. A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression
22. PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium
23. Analysis of the prestarvation response in growing cells of Dictyostelium discoideum
24. Initial cell-type choice in a simple eukaryote: Cell-autonomous or morphogen-gradient dependent?
25. Organization of the ribosomal genes of Dictyostelium
26. Dictyostelium rDNA consists of nonchromosomal palindromic dimers containing 5S and 36S coding regions
27. The Dictyostelium discoideum mitochondrial genome: A primordial system using the universal code and encoding hydrophilic proteins atypical of metazoan mitochondrial DNA
28. Identification of the cell fate gene stalky in Dictyostelium
29. A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium
30. The target of ammonia action in Dictyostelium
31. An unusual adenosine 3′,5′-phosphate dependent protein kinase from Dictyostelium discoideum
32. The 'prespore-like cells' of Dictyostelium have ceased to express a prespore gene: Analysis using short-lived beta-galactosidases as reporters
33. Optimization and in situ detection of Escherichia coli beta-galactosidase gene expression in Dictyostelium discoideum
34. Analysis of cell movement during the culmination phase of Dictyostelium development
35. Propagating waves control Dictyostelium discoideum morphogenesis
36. Role of phospholipase C in Dictyostelium- formation of inositol 1,4,5-triphosphate and normal development in cells lacking phospholipase C activity
37. LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium
38. Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in Dictyostelium
39. Two distinct populations of prestalk cells within the tip of the migratory Dictyostelium slug with differing fates at culmination
40. A Dictyostelium prespore-specific gene is transcriptionally repressed by DIF in vitro
41. Regulation of functionally related enzymes during alternative developmental programs
42. Whole-mount in situ hybridization of cell-type-specific mRNAs in Dictyostelium
43. A serum response factor homolog is required for spore differentiation in Dictyostelium
44. Chemotaxis to cAMP and slug migration in Dictyostelium both depend on MigA, a BTB protein
45. Dictyostelium: A model for regulated cell movement during morphogenesis
46. Sequence of the Dictyostelium discoideum spore coat gene Sp96
47. Spore coat genes SP60 and SP70 of Dictyostelium discoideum
48. Coordinate regulation of the spore coat genes in Dictyostelium discoideum
49. Cyclic nucleotide phosphodiesterase of Dictyostelium discoideum and its glycoprotein inhibitor - Structure and expression of their genes
50. The isolation and characterization of a component of the surface sheath of Dictyostelium discoideum
51. The role of the fibrillar component of the surface sheath in the morphogenesis of Dictyostelium discoideum
52. cudA: A Dictyostelium gene with pleiotropic effects on cellular differentiation and slug behaviour
53. Immunolocalization and separation of multiple prestalk cell types in Dictyostelium
54. Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium
55. Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase
56. Cellular and subcellular distribution of a cAMP-regulated prestalk protein and prespore protein in Dictyostelium discoideum: A study on the ontogeny of prestalk and prespore cells
57. Nitrogen metabolism of the slime mold Dictyostelium discoideum during growth and morphogenesis
58. The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system
59. Developmental and spatial regulation of a Dictyostelium prespore gene - cis-acting elements and a cAMP-induced, developmentally regulated DNA binding activity
60. The role of the cyclic nucleotide phosphodiesterase of Dictyostelium discoideum during growth, aggregation, and morphogenesis: Overexpression and localization studies with the separate promoters of the pde
61. The homeobox-containing gene Wariai regulates anterior-posterior patterning and cell-type homeostasis in Dictyostelium
62. Multiple roles for cAMP-dependent protein kinase during Dictyostelium development
63. Culmination in Dictyostelium is regulated by the cAMP-dependent protein kinase
64. Glycogen synthase kinase 3 regulates cell fate in Dictyostelium
65. A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes
66. Activation of the prespore and spore cell pathway of Dictyostelium differentiation by cAMP-dependent protein kinase and evidence for its upstream regulation by ammonia
67. Protein kinase A is a positive regulator of spore coat gene transcription in Dictyostelium
68. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
69. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium
70. Two cAMP receptors activate common signaling pathways in Dictyostelium
71. DIF-1 induces its own breakdown in Dictyostelium
72. The initiation of basal disc formation in Dictyostelium discoideum is an early event in culmination
73. An analysis of culmination in Dictyostelium using prestalk and stalk-specific cell autonomous markers
74. Localization of the G protein βγ complex in living cells during chemotaxis
75. Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development
76. Evidence that a combined activator-repressor protein regulates Dictyosteliumstalk cell differentiation
77. SH2 signaling in a lower eukaryote: A STAT protein that regulates stalk cell differentiation in Dictyostelium
78. Morphogen hunting in Dictyostelium
79. Mound-cell movement and morphogenesis in Dictyostelium
80. A novel adenylyl cyclase detected in rapidly developing mutants of Dictyostelium
81. The novel Tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification
82. A chemoattractant receptor controls development in Dictyostelium discoideum
83. amiB, a novel gene required for the growth/differentiation transition in Dictyostelium
84. Regulation and function of G-alpha protein subunits in Dictyostelium
85. Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA
86. Ordered yeast artificial chromosome clones representing the Dictyostelium discoideum genome
87. Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction
88. Differential cell cohesiveness expressed by prespore and prestalk cells of Dictyostelium discoideum
89. A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium
90. A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in dictyostelium
91. The genome of Dictyostelium discoideum
92. Consensus phylogeny of Dictyostelium
93. Two-component signal transduction systems in eukaryotic microorganisms
94. Integrated maps of the chromosomes in Dictyostelium discoideum
95. The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium
96. The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase
97. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium - Role of heterotrimeric G proteins
98. Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium
99. Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium
100. Chemotactic cell sorting in Dictyostelium discoideum
101. The cell cycle and sorting behaviour in Dictyostelium discoideum
102. Chemotaxis-associated properties of separated prestalk and prespore cells of Dictyostelium discoideum
103. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
104. Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium
105. Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis
106. The Drosophila serum response factor gene is required for the formation of intervein tissue of wing and is allelic to blistered
107. The regulative capacity of prespore amoeba as demonstrated by fluorescence-activated cell sorting and green fluorescent protein
108. Alternative developmental pathways determined by environmental conditions in the cellular slime mold Dictyostelium discoideum
109. The developmental fate of Dictyostelium discoideum cells depends greatly on the cell-cycle position at the onset of starvation
110. A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression
111. Folic acid as second chemotactic substance in the cellular slime moulds
112. Variables controlling the expression level of exogenous genes in Dictyostelium
113. Molecular genetics of signal transduction in Dictyostelium
114. G protein signaling events are activated at the leading edge of chemotactic cells
115. Identification of a signal transduction response sequence element necessary for induction of a Dictyostelium discoideum gene by extracellular cyclic AMP
116. Identification of a DNA sequence element required for efficient expression of a developmentally regulated and cAMP-inducible gene of Dictyostelium discoideum
117. Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium ceils lacking the aggregation adenylyl cyclase (ACA)
118. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development
119. The cyclic nucleotide phosphodiesterase of Dictyostelium discoideum: The structure of the gene and its regulation and role in development
120. Detection of subtle phenotypes: The case of the cell adhesion molecule csA in Dictyostelium
121. A GBF-binding site and a novel AT element define the minimal sequences sufficient to direct prespore-specific expression in Dictyostelium discoideum
122. Role of cAMP-dependent protein kinase during growth and early development of Dictyostelium discoideum
123. Pseudoplasmodium formation and organization in Dictyostelium discoideum
124. Expression of early developmental genes in Dictyostelium discoideum is initiated during exponential growth by an autocrinedependent mechanism
125. Induction of gene expression in Dictyostelium by prestarvation factor, a factor secreted by growing cells
126. Progression of an inductive signal activates sporulation in Dictyostellum discoideum
127. CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum
128. The cAMP receptor subtype cAR2 is restricted to a subset of prestalk cells during Dictyostelium development and displays unexpected DIF-1 responsiveness
129. Ammonia determines the choice of morphogenetic pathways in Dictyostelium discoideum
130. Serpentine cAM P receptors may act through a G protein-independent pathway to induce postaggregative development in Dictyostelium
131. Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium
132. A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium
133. Mitochondrial DNA replication but no nuclear DNA replication during development of Dictyostelium
134. Cell type regulation in response to expression of ricin-A in Dictyostelium
135. Developmental signal transduction pathways uncovered bY genetic suppressors
136. A cAMP-phosphodiesterase controls PKA-dependent differentiation
137. A multidrug resistance transporter serine protease gene is required for prestalk specialization in Dictyostelium
138. Three-dimensional scroll waves organize Dictyostellum slugs
139. Spiral and concentric waves organize multicellular Dictyostelium mounds
140. The histidine kinase dhkC regulates the choice between migrating slugs and terminal differentiation in Dictyostelium discoideum
141. Involvement of a cell-surface glycoprotein in the cell-sorting process of Dictyostelium discoideum
142. The effect of salts and organic solutes on the migration time of the slime mold Dictyostelium discoideum
143. An adenylyl cyclase that functions during late development of Dictyostelium
144. Wnt signaling and dorso-ventral axis specification in vertebrates
145. Sorting of the initial cell types in Dictyostelium is dependent on the tipA gene
146. Cell sorting during pattern formation in Dictyostelium
147. lagC-null and gbf-null cells define key steps in the morphogenesis of Dictyostelium mounds
148. Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostellum
149. "Cultivation and synchronousmorphogenesis of Dictyostelium under controlled experimental conditions."
150. An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium
151. The role of DIF-1 signaling in Dictyostelium development
152. Chemotactic sorting to cAMP in the multicellular stages of Dictyostelium development
153. 2+ signaling is not required for chemotaxis in Dictyostelium
154. The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium
155. Altered cGMP phosphodiesterase activity in chemotactic mutants of Dictyostelium discoideum
156. The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding
157. A two-component histidine kinase gene that functions in Dlctyostelium development
158. SDF-2 induction of terminal differentiation in Dictyostelium discoideum is mediated by the membrane-spanning sensor kinase DhkA
159. A revision of the Dictyostelium discoideum cell cycle
160. Modulation of the cAMP relay in Dictyostelium discoideum by ammonia and other metabolites: Possible morphogenetic consequences
161. Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) triphosphate
162. RtoA links initial cell type choice to the cell cycle in Dictyostelium
163. The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium
164. A density-sensing factor regulates signal transduction in Dictyostelium
165. Glycoprotein complexes interacting with cellulose in the "cell print" zones of the Dictyostelium discoideum extracellular matrix
166. cAMP-dependent protein kinase is required for the expression of a gene specifically expressed in Dictyostelium prestalk cells
167. Analysis of cell cycle progression during the development of Dictyostelium and its relationship to differentiation