Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line

Breast Cancer Research

Volumn 2, Issue 2, 2000, Pages 139-148

  Annab, L A ^a   Hawkins, R E ^a   Solomon, G ^a   Barrett, J C ^a   Afshari, C A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Antisense; BRCA1; Cell death; Estrogen; Ovarian cancer; Proliferation

Indexed keywords

AGAR; BRCA1 PROTEIN; COMPLEMENTARY DNA; ESTROGEN;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CLONE; CONTROLLED STUDY; CORRELATION FUNCTION; GENE EXPRESSION; HORMONE RESPONSE; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MONOLAYER CULTURE; MOUSE; NONHUMAN; ONCOGENE; OVARY; OVARY CARCINOMA; REGULATORY MECHANISM;

ADENOCARCINOMA; ANIMALS; BRCA1 PROTEIN; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; ESTROGENS; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MICE, NUDE; OVARIAN NEOPLASMS; RECEPTORS, ESTROGEN; RETROVIRIDAE; RNA, ANTISENSE; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034469046     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr45     Document Type: Article

References (55)

1. BRCA1 mutations in primary breast and ovarian carcinomas
2. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
3. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
4. A somatic BRCA1 mutation in an ovarian tumour
5. Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage
6. BRCA1 is a cell cycle-regulated nuclear phosphoprotein
7. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
8. Hormone-dependent regulation of BRCA1 in human breast cancer cells
9. BRCA1 expression is not directly responsive to estrogen
10. Estrogen upregulation of BRCA1 expression with no effect on localization
11. Complex regulation of the BRCA1 gene
12. Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation
13. Characterization of a human ovarian carcinoma cell line with estrogen and progesterone receptors
14. Induction of apoptosis by the tumor suppressor protein BRCA1
15. BRCA1 physically associates with p53 and stimulates its transcriptional activity
16. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
17. An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers
18. Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers
19. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
20. Apoptosis in the pathogenesis and treatment of disease
21. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells
22. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium
23. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews
24. Identification of a RING protein that can interact in vivo with the BRCA1 gene product
25. BRCA1 is a component of the RNA polymerase II holoenzyme
26. Transcriptional activation by BRCA1
27. Evidence for a transcriptional activation function of BRCA1 C-terminal region
28. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues
29. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
30. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
31. Improved retroviral vectors for gene transfer and expression
32. Characterization of the human cyclophilin gene and of related processed pseudogenes
33. BG-1 ovarian cell line: An alternative model for examining estrogen-dependent growth in vitro
34. Induction of apoptosis in rat thecal/interstitial cells by transforming growth factor alpha plus transforming growth factor beta in vitro
35. Spontaneous apoptosis of cells prepared from the nonregressing corpus luteum
36. Egg-cumulus-oviduct interactions and fertilization
37. Increased bax and interleukin-1beta-converting enzyme messenger ribonucleic acid levels coincide with apoptosis in the bovine corpus luteum during structural regression
38. Regulation of ovarian follicle atresia
39. Brca1 is expressed independently of hormonal stimulation in the mouse ovary
40. Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice
41. Genomic deletions in the BRCA1, BRCA2 and TP53 regions associate with low expression of the estrogen receptor in sporadic breast carcinoma
42. Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women
43. Tumour biological features of BRCA1-induced breast and ovarian cancer
44. Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines
45. Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells
46. Association of BRCA1 with Rad51 in mitotic and meiotic cells
47. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
48. Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts
49. Growth retardation and tumour inhibition by BRCA1
50. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
51. BRCA1 as a potential human prostate tumor suppressor: Modulation of proliferation, damage responses and expression of cell regulatory proteins
52. Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair [news]
53. Methylation of the BRCA1 gene in sporadic breast cancer