Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs

Anti-Cancer Drug Design

Volumn 15, Issue 6, 2000, Pages 397-403

  Pettit, G R ^a   Minardi, M D ^a   Boyd, M R ^a   Pettit, R K ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Cation salts; Combretastatin A 3; Diphosphate; Prodrugs

Indexed keywords

ANTINEOPLASTIC AGENT; COMBRESTASTATIN A3; GALLIC ACID METHYL ESTER; ISOVANILLIN; PHOSPHONIUM DERIVATIVE; POTASSIUM SALT; PRODRUG; PYROPHOSPHATE; SODIUM COMBRETASTATIN A3 3,3' O PHOSPHATE; UNCLASSIFIED DRUG;

AIR TEMPERATURE; ANIMAL CELL; ANTIBIOTIC SENSITIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; DRUG MANUFACTURE; DRUG METABOLISM; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; WATER PERMEABILITY;

ANISOLES; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PRODRUGS; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034434231     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Synthesis, X-ray crystal structure and tubulin-binding properties of a benzofuran analogue of the potent cytotoxic agent combretastatin A-4
2. The NCI in vitro anticancer drug discovery screen; concept, implementation and operation 1985-1995
3. Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A-4 phosphate
4. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
5. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
6. The effect of of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors
7. The synthesis of (E) and (Z)-combretastatins A-4 and a phenanthrene from Combretum caffrum
8. A selective removal of benzyl protecting groups in aryl phosphate esters with bromotrimethyl silane
9. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
10. Synthesis and antineoplastic activity of combretastatin analogues: Heterocombretastatins
11. Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins
12. Effects of combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines
13. A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors
14. Novel combretastatin analogues effective against murine solid tumors: Design and structure-activity relationships
15. Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs
16. Antineoplastic agents 389. New synthesis of combretastatin A-4 prodrug
17. Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2
18. Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs
19. Antineoplastic agents 291. Isolation and synthesis of combretastatin A-4, A-5, and A-6
20. Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug
21. Antineoplastic agents 460. Synthesis of combretastatin A-2 prodrugs
22. Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S) and (1R,2R)-1,2-dihydroxy-1- (2′,3′-dihydroxy-4′-methoxyphenyl)-2- (3″,4″,5″-trimethoxyphenyl)-ethane
23. Tumor-associated angiogenesis: Mechanisms, clinical implications, and therapeutic strategies
24. Phase I pharmacokinetics study of single dose intravenous (IV) combretastatin A-4 prodrug (CA4P) in patients (pts) with advanced cancer
25. Leishmanicidal activity of combretastatin analogues and heteroanalogues
26. Microtubule depolymerization in Uromyces appendiculatus by three new antineoplastic drugs: Combretastatin A-4, dolastatin 10 and halichondrin B
27. Combretastatin A-4 phosphate (CA4P) selectively targets vasculature in animal and human tumors
28. Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells
29. A simple, rapid and efficient protocol for the selective phosphorylation of phenols with dibenzyl phosphite
30. Isolation, structure and synthesis of combretastatin C-1
31. Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4