Search for intermediate structures in transthyretin fibrillogenesis: Soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils

Journal of Molecular Biology

Volumn 304, Issue 3, 2000, Pages 461-470

  Redondo, Clara ^a,b   Damas, Ana Margarida ^a,b   Olofsson, Anders ^c   Lundgren, Erik ^c   Saraiva, Maria João M ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Amyloid; Amyloid neuropathy; Epitopes; Intermediates; Transthyretin

Indexed keywords

AMYLOID; EPITOPE; MONOCLONAL ANTIBODY; PHENYLALANINE; PREALBUMIN; TETRAMER; TYROSINE;

AMYLOID NEUROPATHY; ARTICLE; BINDING AFFINITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

EID: 0034405428     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4220     Document Type: Article

References (22)

1. Comparative stability and clearance of Met30 transthyretin and Met119 transthyretin
2. Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å
3. 'In vitro' amyloid fibril formation from transthyretin: The influence of ions and the amyloidogenicity of TTR variants
4. Compound heterozygote of transthyretin Met30 and transthyretin Met119 are protected from the devastating effects of familial amyloid polyneuropathy
5. Familial Amyloid Polyneuropathy: An electron microscope study of the peripheral nerve in five cases
6. Isolation, characterisation, cDNA cloning and gene expression of an avian transthyretin. Implications for the evolution of structure and function of transthyretin in vertebrates
7. Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial Amyloidotic Polyneuropathy (FAP)
8. Characterisation of two highly amyloidogenic mutants of transthyretin
9. Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants
10. Mechanisms of transthyretin amyloidogenesis: Antigenic mapping of transthyretin purified from plasma and amyloid fibrils and within in situ tissue localisations
11. Analysis of X-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 familial amyloidotic polyneuropathy (FAP) patients: Axially arrayed TTR monomers constitute the protofilament
12. Transthyretin Pro55 a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement
13. A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid fibril formation
14. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid
15. A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilisation of ligands
16. Antibody recognition of amyloidogenic transthyretin variants in serum of patients with familial amyloidotic polyneuropathy
17. Designing transthyretin mutants affecting tetrameric structure: Implications in amyloidogenicity
18. Molecular genetics of Familial Amyloidotic Polyneuropathy
19. Transthyretin (prealbumin) in familial amyloidotic polyneuropathy: Genetic and functional aspects
20. The evolution of gene expression, structure and function of transthyretin
21. The crystal structure of amyloidogenic Leu55Pro transthyretin variant reveals a possible pathway for transthyretin polymerisation into amyloid fibrils
22. 1H-NMR structural studies of a cystine-linked peptide containing residue 71-93 of transthyretin and effects of a Ser84 substitution implicated in Familial Amyloidotic Polyneuropathy