Who gets alcoholic liver disease: Nature or nurture?

Journal of the Royal College of Physicians of London

Volumn 34, Issue 6, 2000, Pages 557-562

  Day, Christopher P ^a,b  

^a FREEMAN HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ALCOHOLISM; ANTIBODY PRODUCTION; DIET; DOSE RESPONSE; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; OXIDATIVE STRESS; PATHOLOGY; PROGNOSIS; REVIEW; RISK FACTOR; SEX DIFFERENCE;

ADULT; AGED; ALCOHOLISM; ANTIBODY FORMATION; CYTOKINES; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MIDDLE AGED; OXIDATIVE STRESS; PROGNOSIS; RISK FACTORS; SEX FACTORS;

EID: 0034332342     PISSN: 00358819     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Bellentani S, Saccoccio G, Costa G, Tiribelli C, et al. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 1997;41:845-50.
2. Grove J, Daly AK, Brown AStJM, Bassendine MF, et al. The Rsa polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype. Pharmacogenetics 1998; 8:335-42.
3. Parlesak A, Schafer C, Schutz T, Bode JC, Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 2000;32:742-7.
4. Rotily M, Durbec JP, Berthezene P, Sarles H. Diet and alcohol in liver cirrhosis: a case-control study. EurJ Clin Nutr 1990;44:595-603.
5. Naveau S, Giraud V, Borotto E, Aubert A, et al. Excess weight risk factor for alcoholic liver disease. Hepatology 1997;25:108-11.
6. Day CP, James OFW. Hepatic steatosis - innocent bystander or guilty party? Hepatology 1998;27:1463-6.
7. Teli MR, Day CP, Burt AD, Bennett MK, James OFW. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 1995;346:987-90.
8. Reeves HL, Burt AD, Wood S, Day CP. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. J Hepatol 1996;25:677-83.
9. Day CP, James OFW. Steatohepatitis - a tale of two "hits"? Gastroenterology 1998;114:842-45.
10. Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of Steatohepatitis. Proc Natl Acad Sci USA 1997;94:2557-62.
11. Day CP, James OFW, Brown AStJM, Bennett MK, et al. The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in man. Hepatology 1993;18:832-8.
12. Enomoto N, Yamashina S, Schemmer P, Rivera CA, et al. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Am J Physiol 1999;277:G671-7.
13. Hrubec Z, Omenn GS. Evidence for genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res 1981;5:207-15.
14. Grove J, Daly AK, Burt AD, Guzail M, et al. Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease. Gut 1998;43:262-6.
15. Day CP, Bashir R, James OFW, Bassendine MF, et al. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol related end-organ damage. Hepatology 1991;14:798-801.
16. Borràs E, Coutelle C, Rosell A, Fernández-Muixi F, et al. Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology 2000;31:984-9.
17. Grove J, Daly AK, Bassendine MF, Gilvarry E, Day CP. Polymorphism associated with low Interleukin-10 production is a risk factor for associated alcoholic liver disease. Gut 2000;46:540-5.
18. Grove J, Daly AK, Bassendine MF, Day CP. Association of a tumor necrosis factor polymorphism with susceptibility to alcoholic Steatohepatitis. Hepatology 1997;26:143-6.
19. Israel Y. Antibodies against ethanol-derived protein adducts: pathogenic implications. Gastroenterology 1997;113:353-5.
20. Day CP, Chen Y, Agarwal K, Daly AK. CTLA-4 gene polymorphism associated with autoimmune disease is a risk factor for advanced alcoholic liver disease. Hepatology 1999;30:437A.