Virus mutators and antimutatorsroles in evolution, pathogenesis and emergence

Trends in Genetics

Volumn 16, Issue 11, 2000, Pages 512-517

  Mansky, Louis M ^a   Cunningham, Kristopher S ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; MUTAGENIC AGENT; RECOMBINANT RNA; RNA DIRECTED DNA POLYMERASE; SIALIDASE; URACIL DNA GLYCOSYLTRANSFERASE; VIRUS RNA;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIOPHAGE T4; EVOLUTION; GENETIC VARIABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA VIRUS A; MUTATION RATE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VIRUS MUTATION; VIRUS PATHOGENESIS; ALLELE; GENETICS; MUTATION; VIRAL PHENOMENA AND FUNCTIONS; VIRUS;

RNA VIRUSES;

ALLELES; EVOLUTION; MUTATION; PHENOTYPE; VIRAL PHYSIOLOGY; VIRUSES;

EID: 0034310726     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(00)02125-9     Document Type: Article

References (49)

1. A constant rate of spontaneous mutation in DNA-based microbes
2. Rates of spontaneous mutation among RNA viruses
3. Mutation rates among RNA viruses
4. Regulation of DNA polymerase exonucleolytic proofreading activity: studies of bacteriophage T4 'antimutator' DNA polymerases
5. Mutagenic DNA polymerase
6. Genetic control of mutation rates in bacteriophage T4
7. A new look at old mutants of T4 DNA polymerase
8. DNA polymerase fidelity: from genetics toward a biochemical understanding
9. Crystal structure of a pola family replication DNA polymerase from bacteriophage RB69
10. Products of bacteriophage T4 genes 32 and 45 improve the accuracy of DNA replication in vitro
11. Mutator effects of alleles of phage T4 genes 32, 41, 44, and 45 in the presence of an antimutator polymerase
12. Role of mutator alleles in adaptive evolution
13. Antimutator mutants in bacteriophage T4 and Escherichia coli
14. Conjunctivitis in human beings caused by influenza A virus of seals
15. Evolution and ecology of influenza A viruses
16. Genetic relatedness of hemagglutinins of the H1 subtype of influenza A viruses isolated from swine and birds
17. Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site
18. Probing of the receptor-binding sites of the H1 and H3 influenza A and influenza B virus hemagglutinins by synthetic and natural sialoside
19. Origin and evolution of the 1918 'Spanish' influenza virus hemagglutinin gene
20. Receptor binding properties of human and animal H1 influenza virus isolates
21. Heterogeneity of the mutation rates of inflenza A viruses: isolation of mutator mutants
22. Evolution of pig influenza viruses
23. Molecular evolution of influenza viruses
24. European swine virus as a possible source for the next influenza pandemic?
25. Natural selection and mutability
26. Independence of evolutionary and mutational rates after transmission of avian influenza viruses to swine
27. Selection for high mutation rates in chemostats
28. Transposable elements as mutator genes in evolution
29. Increased viral pathogenicity after insertion of a 28S ribosomal RNA sequence into the haemagglutinin gene of an influenza virus
30. 3'-azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency type 1
31. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance
32. Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain
33. Role of the 'helix clamp' in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis
34. New human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) mutants with increased fidelity of DNA synthesis
35. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
36. Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase
37. Selection, recombination, and G to A hypermutation of human immunodeficiency virus type 1 genomes
38. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations
39. In vivo analysis of human T-cell leukemia virus reverse transcription accuracy
40. 5-azacytidine and RNA secondary structure increase the retrovirus mutation rate
41. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis
42. Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immuondeficiency virus type 1 reverse transcriptase
43. Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase
44. The mutation rate of human immunodeficiency virus type 1 is influenced by the vpr gene
45. The interaction of Vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 in vivo mutation rate
46. Lethal mutagenesis of HIV with mutagenic nucleoside analogs