Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association

Biochemical Journal

Volumn 351, Issue 1, 2000, Pages 151-159

  Yip Schneider, M T ^a   Miao, W ^a   Lin, A ^a   Barnard, D S ^a   Tzivion, G ^a   Marshall, M S ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

CR3; Raf; Serine 338

Indexed keywords

ADAPTOR PROTEIN; GUANOSINE TRIPHOSPHATE; PHORBOL ESTER DERIVATIVE; PHOSPHOSERINE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RAF 1 KINASE; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMAL; BINDING, COMPETITIVE; CATALYTIC DOMAIN; COS CELLS; ENZYME ACTIVATION; MUTATION; ONCOGENE PROTEIN PP60(V-SRC); PEPTIDE FRAGMENTS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RAF; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; TYROSINE 3-MONOOXYGENASE;

EID: 0034306451     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510151     Document Type: Article

References (40)

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3. Mutational activation of c-raf-1 and definition of the minimal transforming sequence
4. Bcr and Raf form a complex in vivo via 14-13-3 proteins
5. 14-13-3 proteins associate with cdc25 phosphatases
6. The protein kinase KSR interacts with 14-13-3 protein and Raf
7. 14-13-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
8. Post-translationally modified 14-13-3 isoforms and inhibition of protein kinase C
9. Regulation of Raf-1 kinase activity by the 14-13-3 family of proteins
10. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-13-3 not BCL-XL
11. Mechanisms regulating Raf-1 activity in signal transduction pathways
12. Identification of the major phosphorylation sites of the Raf-1 kinase
13. A dimeric 14-13-3 protein is an essential cofactor for Raf kinase activity
14. 14-13-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity
15. 14-13-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo
16. Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms
17. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
18. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
19. Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signalling
20. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
21. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
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23. Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells
24. Signal transduction from membrane to cytoplasm: Growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity
25. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
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31. Erratum
32. Interaction of 14-13-3 with signaling proteins is mediated by the recognition of phosphoserine
33. Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: Reconstitution of the signalling pathway in vitro
34. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
35. Hot lips and phosphorylation of protein kinases
36. Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila
37. Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility
38. Activated Ras displaces 14-13-3 protein from the amino terminus of c-Raf- 1
39. 14-13-3 is not essential for Raf-1 function: Identification of Raf-1 proteins that are biologically activated in a 14-13-3- and Ras-independent manner