Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase of Isolates from the Amazon Region of Brazil

Memorias do Instituto Oswaldo Cruz

Volumn 95, Issue 5, 2000, Pages 721-728

  Vasconcelos, K F ^a   Plowe, C V ^d   Fontes, C J ^b   Kyle, D ^d   Wirth, D F ^d   Pereira Da Silva, L H ^c   Zalis, M G ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF MATO GROSSO   (Brazil)

^c Ctro de Pesquisa em Med Tropical   (Brazil)

^d NONE

Author keywords

Brazilian Amazon; Dihydrofolate reductase; Dihydropteroate synthase; Drug resistance; Malaria; Plasmodium falciparum

Indexed keywords

CAESALPINIA CILIATA; PLASMODIUM FALCIPARUM; RONDONIA;

AMINO ACID; ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; PROTOZOAL PROTEIN;

ADULT; AGED; ANIMAL; ARTICLE; BRAZIL; CLINICAL TRIAL; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; GENOTYPE; HUMAN; ISOLATION AND PURIFICATION; MALARIA; MALE; MIDDLE AGED; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION;

ADULT; AGED; AMINO ACIDS; ANIMALS; ANTIMALARIALS; BRAZIL; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE; GENOTYPE; HUMANS; MALARIA; MALE; MIDDLE AGED; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0034267180     PISSN: 00740276     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0074-02762000000500020     Document Type: Article

References (26)

1. Alecrim MG, Alecrim WD, de Albuquerque BC, Dourado HV, Wanssa MD 1982a. In vivo resistance of Plasmodium falciparum to the combination of sulfamethoxazole and trimethoprim in the Brazilian Amazonas. Rev Inst Med Trop São Paulo 24: 48-51.
2. Alecrim MG, Alecrim WD, de Albuquerque BC, Dourado HV, Wanssa MD 1982b. Resistance of Plasmodium falciparum in the Brazilian Amazon to the combination of sulfadoxine and pyrimethamine. Rev Inst Med Trop São Paulo 24: 44-47.
3. Alecrim WD, Dourado H, Alecrim MG, Passos LF, Wanssa E, Albuquerque B 1982c. In vitro resistance of Plasmodium falciparum to the combination of sulfadoxine and pyrimethamine, at RIII level, in Amazonas, Brazil. Rev Inst Med Trop São Paulo 24: 52-53.
4. Andrade JG, Andrade ALS, Araujo ESO, Oliveira RM, Silva AS, Martelli CMT, Zucker F 1992. A randomized clinical trial with high dose of chloroquine for treatment of Plasmodium falciparum malaria in Brazil. Rev Inst Med Trop São Paulo 34: 467-473.
5. Cortese JF, Plowe CV 1998. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol Biochem Parasitol 94: 205-214.
6. Cowman AF, Morry MJ, Biggs BA, Cross GA, Foote SJ 1988. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA 85: 9109-9113.
7. de Pecoulas PE, Basco LK, Le Bras J, Mazabraud A 1996. Association between antifolates resistance in vitro and DHFR gene point mutation in Plasmodium falciparum isolates. Trans R Soc Trop Med Hyg 90: 181-182.
8. Foote SJ, Cowman AF 1994. The mode of action and the mechanism of resistance to antimalarial drugs. Acta Trop 56: 157-171.
9. Foote SJ, Galatis D, Cowman AF 1990. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Proc Natl Acad Sci USA 87: 3014-3017.
10. Kremsner PG, Zotter GM, Feldmeier H, Graninger W, Kollaritsch M, Wiedermann G, Rocha RM, Wernsdorfer WH 1989. In vitro drug sensitivity of Plasmodium falciparum in Acre, Brazil. Bull World Health Org 67: 289-293.
11. Kublin JG, Witzig RS, Shankar AH, Zurita JQ, Gilman RH, Guarda JA, Cortese JF, Plowe CV 1998. Molecular assays for surveillance of antifolate-resistant malaria. Lancet 351: 1629-1630.
12. Marques AC 1993. Epidemiologic data on malaria in the Amazon region, by municipality, in 1992. Rev Soc Bras Med Trop 26: 43-59.
13. Marques AC 1995. Epidemiological data on malaria for all of Brazil in 1993. Rev Soc Bras Med Trop 28: 141-155.
14. Milhous WK, Weatherly NF, Bowdre JH, Desjardins RE 1985. In vitro activities and mechanisms of resistance to antifolates. Antimicrub Agents Chemother 27: 525-530.
15. Neifer S, Kremsner PG 1991. Drug susceptibility of Plasmodium falciparum in the western Amazon region, State of Acre, Brazil. Rev Inst Med Trop São Paulo 33: 205-211.
16. Peterson DS, Walliker D, Wellems TE 1988. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA 85: 9114-99118.
17. Peterson DS, Milhous WK, Wellems TE 1990. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci USA 87: 3018-3022.
18. Peterson DS, di Santi SM, Povoa M, Calvosa VS, Do Rosario VE, Wellems TE 1991. Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon. Am J Trop Med Hyg 45: 492-497.
19. Plowe CV, Cortese JF, Djimde A, Nwanyanwu OC, Watkins WM, Winstanley PA, Estrada-Franco JG, Mollinedo RE, Avila JC, Cespedes JL, Carter D, Doumbo OK 1997. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J Infect Dis 176: 1590-1596.
20. Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE 1995. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52: 565-568.
21. Trager W, Jensen JB 1997. Continuous culture of Plasmodium falciparum: its impact on malaria research. Int J Parasitol 27: 989-1006.
22. Triglia T, Menting JG, Wilson C, Cowman AF 1997. Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 94: 13944-13949.
23. Wang P, Brooks DR, Sims PF, Hyde JE 1995. A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum. Mol Biochem Parasitol 71: 115-125.
24. Wang P, Lee CS, Bayoumi R, Djimde A, Doumbo O, Swedberg G, Dao LD, Mshinda H, Tanner M, Watkins WM, Sims PF, Hyde JE 1997a. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol 89: 161-177.
25. Wang P, Read M, Sims PF, Hyde JE 1997b. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol Microbial 23: 979-986.
26. Zalis MG, Pang L, Silveira MS, Milhous WK, Wirth DF 1998. Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance. Am J Trop Med Hyg 58: 630-637.