-
1
-
-
0028891465
-
A pharmacogenetic basis for the safe and effective use of azathioprine and other thiopurine drugs in dermatologic patients
-
Snow JL, Gibson LE. A pharmacogenetic basis for the safe and effective use of azathioprine and other thiopurine drugs in dermatologic patients. J Am Acad Dermatol 1995; 32: 114-6.
-
(1995)
J Am Acad Dermatol
, vol.32
, pp. 114-116
-
-
Snow, J.L.1
Gibson, L.E.2
-
2
-
-
0018822866
-
Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
-
Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980; 32: 651-62.
-
(1980)
Am J Hum Genet
, vol.32
, pp. 651-662
-
-
Weinshilboum, R.M.1
Sladek, S.L.2
-
3
-
-
0032921854
-
Methylation pharmacogenetics: Catechol-O methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
-
Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: Catechol-O methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Ann Rev Pharmacol Toxicol 1999; 39: 19-52.
-
(1999)
Ann Rev Pharmacol Toxicol
, vol.39
, pp. 19-52
-
-
Weinshilboum, R.M.1
Otterness, D.M.2
Szumlanski, C.L.3
-
4
-
-
12644291917
-
Human thiopurine methyltransferase pharmacgenetics: Gene sequence polymorphisms
-
Otterness D, Szumlanski C, Lennard L, et al. Human thiopurine methyltransferase pharmacgenetics: Gene sequence polymorphisms. Clin Pharmacol Ther 1997; 62: 60-73.
-
(1997)
Clin Pharmacol Ther
, vol.62
, pp. 60-73
-
-
Otterness, D.1
Szumlanski, C.2
Lennard, L.3
-
5
-
-
0032030953
-
Human thiopurine methyltransferase pharmacogenetics-kindred with a terminal exon splice junction mutation that results in loss of activity
-
Otterness DM, Szmulanski CL, Wood TC, Weinshilboum RM. Human thiopurine methyltransferase pharmacogenetics-kindred with a terminal exon splice junction mutation that results in loss of activity. J Clin Invest 1998; 101: 1036-44.
-
(1998)
J Clin Invest
, vol.101
, pp. 1036-1044
-
-
Otterness, D.M.1
Szmulanski, C.L.2
Wood, T.C.3
Weinshilboum, R.M.4
-
6
-
-
0030048791
-
Thiopurine metyltransferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism
-
Szmulanski C, Otterness D, Her C, et al. Thiopurine metyltransferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism. DNA Cell Biol 1996; 15: 17-30.
-
(1996)
DNA Cell Biol
, vol.15
, pp. 17-30
-
-
Szmulanski, C.1
Otterness, D.2
Her, C.3
-
7
-
-
0039260881
-
Randomized comparison of 6-mercaptopurine vs 6-thioguanine in maintenance treatment of childhood acute lymphoblastic leukemia: Preliminary results [abstract]
-
Harms D, Janka-Schaub GE, Erb N, et al. Randomized comparison of 6-mercaptopurine vs 6-thioguanine in maintenance treatment of childhood acute lymphoblastic leukemia: Preliminary results [abstract]. Br J Haematol 1996; 93(Suppl 2): 58.
-
(1996)
Br J Haematol
, vol.93
, pp. 58
-
-
Harms, D.1
Janka-Schaub, G.E.2
Erb, N.3
-
8
-
-
0031847470
-
Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: A comparison of haematological toxicity and drug metabolite concentrations
-
Lancaster DL, Lennard L, Rowland K, et al. Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: A comparison of haematological toxicity and drug metabolite concentrations. Br J Haematol 1998; 102: 439-43.
-
(1998)
Br J Haematol
, vol.102
, pp. 439-443
-
-
Lancaster, D.L.1
Lennard, L.2
Rowland, K.3
-
9
-
-
0028269944
-
Mercaptopurine metabolism and the risk of relapse in childhood lymphoblastic leukemia
-
Lilleyman JS, Lennard L. Mercaptopurine metabolism and the risk of relapse in childhood lymphoblastic leukemia. Lancet 1994; 343: 1188-90.
-
(1994)
Lancet
, vol.343
, pp. 1188-1190
-
-
Lilleyman, J.S.1
Lennard, L.2
-
11
-
-
0026714550
-
Methylation pharmacogenetics: Thiopurine methyltransferase as a model system
-
Weinshilboum RM. Methylation pharmacogenetics: Thiopurine methyltransferase as a model system. Xenobiotica 1992; 22: 1055-71.
-
(1992)
Xenobiotica
, vol.22
, pp. 1055-1071
-
-
Weinshilboum, R.M.1
-
12
-
-
0025195675
-
6-thioguanine nucleotide accumulation in red cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leucopenia
-
Schmeiglow K, Bruunshuus I. 6-thioguanine nucleotide accumulation in red cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leucopenia. Cancer Chemother Pharmacol 1990; 26: 288-92.
-
(1990)
Cancer Chemother Pharmacol
, vol.26
, pp. 288-292
-
-
Schmeiglow, K.1
Bruunshuus, I.2
-
13
-
-
0027973369
-
The cytotoxicity of thioguanine vs. mercaptopurine in acute lymphoblastic leukemia
-
Adamson PC, Poplack DG, Ballis FM. The cytotoxicity of thioguanine vs. mercaptopurine in acute lymphoblastic leukemia. Leuk Res 1994; 18: 805-10.
-
(1994)
Leuk Res
, vol.18
, pp. 805-810
-
-
Adamson, P.C.1
Poplack, D.G.2
Ballis, F.M.3
-
14
-
-
0027276221
-
Is 6-thioguanine more appropriate than 6-mercaptopurine for children with ALL?
-
Lennard L, Davies HA, Lilleyman JS. Is 6-thioguanine more appropriate than 6-mercaptopurine for children with ALL? Br J Cancer 1993; 68: 186-90.
-
(1993)
Br J Cancer
, vol.68
, pp. 186-190
-
-
Lennard, L.1
Davies, H.A.2
Lilleyman, J.S.3
-
15
-
-
0030871031
-
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis
-
Leipold G, Schutz E, Haas JP, Oellerich M. Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. Arthritis Rheum 1997; 40: 1896-8.
-
(1997)
Arthritis Rheum
, vol.40
, pp. 1896-1898
-
-
Leipold, G.1
Schutz, E.2
Haas, J.P.3
Oellerich, M.4
-
16
-
-
0026443183
-
Pancytopenia related to azathioprine-an enzyme deficiency caused by a common genetic polymorphism: A review
-
Anstey A, Lennard L, Mayou SC, Kirby JD. Pancytopenia related to azathioprine-an enzyme deficiency caused by a common genetic polymorphism: A review. J Royal Soc Med 1992; 85: 752-6.
-
(1992)
J Royal Soc Med
, vol.85
, pp. 752-756
-
-
Anstey, A.1
Lennard, L.2
Mayou, S.C.3
Kirby, J.D.4
-
17
-
-
0027285234
-
Azathioprine induced myelosuppression in thiopurine methyltransferase deficient heart transplant patient
-
McLeod HL, Miller DR, Evans WE. Azathioprine induced myelosuppression in thiopurine methyltransferase deficient heart transplant patient. Lancet 1993; 341: 1151.
-
(1993)
Lancet
, vol.341
, pp. 1151
-
-
McLeod, H.L.1
Miller, D.R.2
Evans, W.E.3
-
18
-
-
0028815315
-
Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation
-
Schutz E, Gummert J, Mohr FW, et al. Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation. Transplant Proc 1995; 27: 1298-300.
-
(1995)
Transplant Proc
, vol.27
, pp. 1298-1300
-
-
Schutz, E.1
Gummert, J.2
Mohr, F.W.3
-
19
-
-
0029160172
-
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis
-
Ben Ari Z, Mehta A, Lennard L, Burroughs AK. Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. J Hepatol 1995; 23: 351-4.
-
(1995)
J Hepatol
, vol.23
, pp. 351-354
-
-
Ben Ari, Z.1
Mehta, A.2
Lennard, L.3
Burroughs, A.K.4
-
20
-
-
0028904225
-
Azathioprine-induced pancytopenia in homozygous thiopurine methyltransferase-deficient renal transplant recipients: A family study
-
Escousse A, Mousson C, Santona L, et al. Azathioprine-induced pancytopenia in homozygous thiopurine methyltransferase-deficient renal transplant recipients: A family study. Transplant Proc 1995; 27: 1739-42.
-
(1995)
Transplant Proc
, vol.27
, pp. 1739-1742
-
-
Escousse, A.1
Mousson, C.2
Santona, L.3
-
21
-
-
0031933720
-
Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency
-
Andersen JB, Szumlanski C, Weinshilboum RM, Schmiegelow K. Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency. Acta Paediatr 1998; 87: 108-11.
-
(1998)
Acta Paediatr
, vol.87
, pp. 108-111
-
-
Andersen, J.B.1
Szumlanski, C.2
Weinshilboum, R.M.3
Schmiegelow, K.4
-
22
-
-
0025837127
-
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
-
Evans WE, Horner M, Chu YQ, Kalwinsky D, Roberts WM. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr 1991; 119: 985-9.
-
(1991)
J Pediatr
, vol.119
, pp. 985-989
-
-
Evans, W.E.1
Horner, M.2
Chu, Y.Q.3
Kalwinsky, D.4
Roberts, W.M.5
-
23
-
-
0027524983
-
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
-
Lennard L, Gibson BE, Nicole T, Lilleyman JS. Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child 1993; 69: 577-9.
-
(1993)
Arch Dis Child
, vol.69
, pp. 577-579
-
-
Lennard, L.1
Gibson, B.E.2
Nicole, T.3
Lilleyman, J.S.4
-
24
-
-
0030802914
-
Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies
-
Lennard L, Lewis IJ, Michelagnoli M, Lilleyman JS. Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies. Med Pediatr Oncol 1997; 29: 252-5.
-
(1997)
Med Pediatr Oncol
, vol.29
, pp. 252-255
-
-
Lennard, L.1
Lewis, I.J.2
Michelagnoli, M.3
Lilleyman, J.S.4
-
25
-
-
0025331198
-
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukemia
-
Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukemia. Lancet 1990; 336: 225-9.
-
(1990)
Lancet
, vol.336
, pp. 225-229
-
-
Lennard, L.1
Lilleyman, J.S.2
Van Loon, J.3
Weinshilboum, R.M.4
-
26
-
-
0030656430
-
Thiopurine drugs in the treatment of childhood leukaemia: The influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity
-
Lennard L, Welch JC, Lilleyman JS. Thiopurine drugs in the treatment of childhood leukaemia: The influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br J Clin Pharmacol 1997; 44: 455-61.
-
(1997)
Br J Clin Pharmacol
, vol.44
, pp. 455-461
-
-
Lennard, L.1
Welch, J.C.2
Lilleyman, J.S.3
-
27
-
-
0024451147
-
Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
-
Lennard L, van Loon JA, Weinshilboum RM. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989; 46: 149-54.
-
(1989)
Clin Pharmacol Ther
, vol.46
, pp. 149-154
-
-
Lennard, L.1
van Loon, J.A.2
Weinshilboum, R.M.3
-
28
-
-
0030934850
-
Molecular diagnosis of thiopurine S-mehtyltransferase deficiency: Genetic basis for azathiprine and mercaptopurine intolerance
-
Yates CR, Krynetski EY, Loennechen T, et al. Molecular diagnosis of thiopurine S-mehtyltransferase deficiency: Genetic basis for azathiprine and mercaptopurine intolerance. Ann Intern Med 1997; 126: 608-14.
-
(1997)
Ann Intern Med
, vol.126
, pp. 608-614
-
-
Yates, C.R.1
Krynetski, E.Y.2
Loennechen, T.3
-
29
-
-
0032231751
-
Pharmacogenetics of cancer therapy: Getting personal
-
Krynetski EY, Evans WE. Pharmacogenetics of cancer therapy: Getting personal. Am J Hum Genet 1998; 63: 11-6.
-
(1998)
Am J Hum Genet
, vol.63
, pp. 11-16
-
-
Krynetski, E.Y.1
Evans, W.E.2
-
30
-
-
0029790730
-
Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism
-
Lennard L, Lilleyman JS. Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism. Ther Drug Monit 1996; 18: 328-34.
-
(1996)
Ther Drug Monit
, vol.18
, pp. 328-334
-
-
Lennard, L.1
Lilleyman, J.S.2
|