Molecular features responsible for the absence of immunoglobulin heavy chain protein synthesis in an IgH- subgroup of multiple myeloma

Blood

Volumn 96, Issue 3, 2000, Pages 1087-1093

  Szczepanski, T ^a   Van't Veer, M B ^a   Wolvers Tettero, I L M ^a   Langerak, A W ^a   Van Dongen, J J M ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN;

ADULT; AGED; ARTICLE; CHROMOSOME TRANSLOCATION 14; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; MULTIPLE MYELOMA; PLASMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SOMATIC MUTATION; SOUTHERN BLOTTING;

EID: 0034254736     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.1087.015k23_1087_1093     Document Type: Article

References (48)

1. Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma
2. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
3. A high frequency of circulating B cells share clonotypic Ig heavy- chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase- polymerase chain reaction
4. The relationship between monoclonal myeloma precursor B cells in the peripheral blood stem cell harvests and the clinical response of multiple myeloma patients
5. Multiple myeloma: Increasing evidence for a multistep transformation process
6. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
7. Improved cytogenetics in multiple myeloma: A study of 151 patients including 117 patients at diagnosis
8. The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization
9. A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
10. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping
11. Multiple myeloma and the translocation t(11;14)(q13;q32): A report on 13 cases
12. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
13. Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma
14. High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
15. Isolation and characterisation of recombination events involving immunoglobulin heavy chain switch regions in multiple myeloma using long distance vectorette PCR (LDV-PCR)
16. Plasma cell myeloma-new biological insights and advances in therapy
17. Nonsecretory multiple myeloma
18. Nonsecretory multiple myeloma: Presenting findings, clinical course and prognosis
19. Nonsecretory multiple myeloma
20. Primary plasma cell leukemia: Clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics
21. Nonsecretory myeloma, immunoglobulin D myeloma, and plasma cell leukemia
22. Immunological marker analysis of ceils in the various hematopoietic differentiation stages and their malignant counterparts
23. Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects
24. Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: Recommendations for optimal results
25. Evolutionary approach to the question of immunoglobulin heavy chain switching: Evidence from cloned human and mouse genes
26. Human immunoglobulin heavy chain genes: Evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences
27. Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes
28. Duplication and deletion in the human immunoglobulin epsilon genes
29. Detection of immunoglobulin kappa light-chain gene rearrangement patterns by Southern blot analysis
30. Southern blot detection of immunoglobulin lambda light chain gene rearrangements for clonality studies
31. Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: Implications for selection of PCR targets for detection of minimal residual disease
32. Primers and protocols for standardized MRD detection in ALL using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in acute leukemia
33. Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies
34. Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor αβ lineage
35. Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: A new molecular target for detection of minimal residual disease
36. Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes
37. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations
38. Human immunoglobulin VH repertoire
39. Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, 'minor' D segments or D-D recombination
40. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
41. Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders
42. Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin
43. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci
44. A plasma cell leukemia patient showing bialleic 14q translocations; t(2; 14) and t(11; 14)
45. Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines
46. A possible mechanism of inability of immunoglobulin heavy-chain production in Bence-Jones type myeloma cells
47. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease