Molecular strategies for overcoming antibiotic resistance in bacteria

Molecular Medicine Today

Volumn 6, Issue 8, 2000, Pages 309-314

  Tan, Yu Ting ^a   Tillett, Darren J ^a   McKay, Ian A ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; BCG VACCINE; PENICILLIN G; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BIOTECHNOLOGY; DNA RECOMBINATION; DRUG DESIGN; DRUG MECHANISM; DRUG RESEARCH; NONHUMAN; REVIEW;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BACTERIA; BACTERIAL INFECTIONS; BACTERIOPHAGES; DEFENSINS; DRUG RESISTANCE, MICROBIAL; GENE TRANSFER TECHNIQUES; HUMANS; PROTEINS; VACCINES;

EID: 0034254448     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(00)01739-1     Document Type: Review

References (30)

1. Levy, S.B. (1998) The challenge of antibiotic resistance. Sci. Am. 278, 46-53
2. Davies, J. (1996) Bacteria on the rampage. Nature 383, 219-220
3. Roccanova, L. and Rappa, P., III (2000) Antibiotic rotation. Science 287, 803
4. Salyers, A. and Amabile-Cuevas, C.F. (1997) Why are antibiotic resistance genes so resistant to elimination? Antimicrob. Agents Chemother. 41, 2321-2325
5. Calva, J.J. et al. (1996) In Antibiotic resistance: from molecular basics to therapeutic options (Amabile-Cuevas, C.F., ed.), pp. 78-79, R.G. Landes
6. Nowak, R. (1994) Hungary sees an improvement in penicillin resistance. Science 264, 364
7. Lloyd, A.W. (1998) Monitor: molecules and profiles. Drug Discov. Today 3, 480
8. Lloyd, A.W. (1998) Monitor: molecules and profiles, Drug Discov. Today 5, 122
9. Huttner, K.M. and Bevins, C.L. (1999) Antimicrobial peptides as mediators of epithelial host defense. Pediatr. Res. 45, 785-794
10. Bensch, K.W. et al. (1995) hBD-1: a novel beta-defensin from human plasma. FEBS Lett. 368, 331-335
11. Harder, J. et al. (1997) A peptide antibiotic from human skin. Nature 387, 861
12. Martinez, A. et al. (1997) Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument. Endocrinology 138, 5597-5604
13. Thennarasu, S. and Nagaraj, R. (1999) Synthetic peptides corresponding to the β-hairpin loop of rabbit defensin NP-2 show antimicrobial activity. Biochem. Biophys. Res. Comm. 254, 281-283
14. Saido-Sakanaka, H. et al. (1999) Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide. Biochem. J. 338, 29-33
15. Tossi, A. et al. (1997) Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity. Eur. J. Biochem. 250, 549-558
16. Breukink, E. et al. (1999) Use of the cell wall Lipid II by a pore-forming peptide antibiotic. Science 286, 2361-2364
17. Ernst, R.K. et al. (1999) Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science 286, 1561-1565
18. Stachelhaus, T. et al. (1996) Engineered biosynthesis of peptide antibiotics. Biochem. Pharm. 52, 177-196
19. Gokhale, R.S. et al. (1999) Dissecting and exploiting intermodular communication in polyketide synthases. Science 84, 482-485
20. Toney, J.H. et al. (1998) Antibiotic sensitisation using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase. Chem. Biol. 5, 185-196
21. Guerrier-Takada, C. et al. (1997) Phenotypic conversion of drug-resistant bacteria to drug sensitivity. Proc. Natl. Acad. Sci. U. S. A. 94, 8468-8472
22. Ge, M. et al. (1999) Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science 284, 507-511
23. Behr, M. et al. (1999) Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284, 1520-1523
24. Tettelin, H. et al. (2000) Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287, 1809-1815
25. Pizza, M. et al. (2000) Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 287, 1816-1820
26. Balaban, N. et al. (1998) Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science 280, 438-440
27. Mason, H.S. et al. (1998) Edible vaccine protects against Escherichia coli heat-labile enterotoxin (LT); potatoes expressing a synthetic LT-B gene. Vaccine 16, 1336-1343
28. Alisky, J. et al. (1998) Bacteriophages show promise as antimicrobial agents. J. Infect. 36, 5-15
29. Kristiansen, J.E. and Amaral, L. (1997) The potential management of resistant infections with non-antibiotics. J. Antimicrob. Chemother. 40, 319-327
30. Heinemann, J.A. (1999) How antibiotics cause antibiotic resistance. Drug Discov. Today 4, 72-79