A novel slow excitatory postsynaptic current in substantia gelatinosa neurons of the rat spinal cord in vitro

Neuroscience

Volumn 76, Issue 3, 1996, Pages 673-688

  Yajiri, Y ^b   Yoshimura, M ^c   Okamoto, M ^b   Takahashi, H ^b   Higashi, H ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c SAGA UNIVERSITY   (Japan)

Author keywords

dorsal horn; excitatory amino acid; NMDA; nociception; pain; primary afferent

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; GLUTAMATE RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; HISTOLOGY; MALE; MEMBRANE CURRENT; NONHUMAN; PAIN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SUBSTANTIA GELATINOSA;

EID: 0030580560     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00291-6     Document Type: Article

References (41)

1. 1. Beal J. A. and Bicknell H. R. Jr. (1985) Development and maturation of neurons in the substantia gelatinosa (SG) of the rat spinal cord. In: Development, Organization and Processing in Somatosensory Pathway (eds Rowe M. and Willis W. D. Jr), pp. 23-30. Wiley-Liss, New York.
2. 2. Brew H. and Attwell D. (1987) Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells. Nature 327, 707-709.
3. 3. Brown A. G. (1982) The dorsal horn of the spinal cord. Q. Jl exp. Physiol. 67, 193-212.
4. 4. De Koninck Y. and Henry J. L. (1991) Substance P-mediated slow excitatory potential elicited in dorsal horn neurons in vivo by noxious stimulation. Proc. natn. Acad. Sci. U.S.A. 88, 11344-11348.
5. 3 receptors are membrane ion channels. Nature 339, 706-709.
6. 6. Geber G. and Randić M. (1989) Participation of excitatory amino acid receptors in the slow excitatory synaptic transmission in the rat spinal dorsal horn in vitro. Neurosci. Lett. 106, 220-228.
7. 7. Inokuchi H., Yoshimura M., Yamada S., Polosa C. and Nishi S. (1992) Fast excitatory postsynaptic potentials and the responses to excitant amino acids of sympathetic preganglionic neurons in the slice of the cat spinal cord. Neuroscience 46, 657-667.
8. 8. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M. and Nakanishi S. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. biol. Chem. 268, 2836-2843.
9. 9. Jahr C. E. and Yoshioka D. (1986) Ia afferent excitation of motoneurones in the in vitro new-born rat spinal cord is selectively antagonized by kynurenate. J. Physiol. 370, 515-530.
10. 10. Kumazawa T. and Perl E. R. (1978) Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn organization. J. comp. Neurol. 177, 417-434.
11. 11. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M. and Mishina M. (1992) Molecular diversity of the NMDA receptor channel. Nature 358, 36-41.
12. 12. Light A. R. and Perl E. R. (1979) Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers. J. comp. Neurol. 186, 133-150.
13. 13. Light A. R., Trevino D. L. and Perl E. R. (1979) Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn. J. comp. Neurol. 186, 151-172.
14. 14. Mayer M. L. and Westbrook G. L. (1984) The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture. J. Physiol. 361, 65-90.
15. 15. Monyer H., Burnashev N., Laurie D. J., Sakman B. and Seeburg P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
16. 16. North R. A. and Yoshimura M. (1984) The actions of noradrenaline on neurones of the rat substantia gelatinosa in vitro. J. Physiol. 349, 43-55.
17. 17. Otsuka M. and Yoshioka K. (1993) Neurotransmitter function of mammalian tachykinins. Physiol. Rev. 73, 229-308.
18. 18. Réthelyi M. (1977) Preterminal and terminal axon arborizations in the substantia gelatinosa of cat's spinal cord. J. comp. Neurol. 72, 511-528.
19. 19. Rexed B. (1952) The cytoarchitectonic organization of the spinal cord in the cat. J. comp. Neurol. 96, 415-495.
20. 20. Ruda M. A., Bennett G. J. and Dubner R. (1986) Neurochemistry and neural circuitry in the dorsal horn. Prog. Brain Res. 66, 219-268.
21. 21. Schneider S. P. and Perl E. R. (1988) Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. J. Neurosci. 8, 2062-2073.
22. 22. Schwartz E. A. and Tachibana M. (1990) Electrophysiology of glutamate and sodium co-transport in a glial cell of the salamander retina. J. Physiol. 426, 43-80.
23. 23. Sivillotti L. G., Thompson S. W. N. and Woolf C. J. (1993) Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro. J. Neurophysiol. 69, 1621-1631.
24. 24. Sugiura Y., Terui N. and Hosoya Y. (1989) Difference in distribution of central terminals between visceral and somatic unmyelinated (C) primary afferent fibers. J. Neurophysiol. 4, 834-840.
25. 25. Surprenant A., Beull G. and North R. A. (1995) P2x receptors bring new structure to ligand-gated ion channels. Trends Neurosci. 18, 224-229.
26. 26. Takahashi T. and Tsuruhara H. (1987) Slow depolarizing potentials recorded from glial cells in the rat superficial dorsal horn. J. Physiol. 388, 597-610.
27. 27. Thompson S. W. N., King A. E. and Woolf C. J. (1990) Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarizations produces a D-2-amino-5-phosphonovaleric acid sensitive windup. Eur. J. Neurosci. 2, 638-649.
28. 28. Tohyama M. and Shiotani Y. (1986) Neuropeptides in spinal cord. Prog. Brain Res. 66, 177-218.
29. 29. Tölle T. R., Berthele A., Zieglgänsberger W., Seeburg P. H. and Wisden W. (1993) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaquaductal gray. J. Neurosci. 1312, 5009-5028.
30. 30. Urban L., Aitken P. G. and Somjen G. G. (1985) Interstitial potassium concentration, slow depolarization and focal potential responses in the dorsal horn of the rat spinal slice. Brain Res. 331, 168-171.
31. 31. Urban L. and Randić M. (1984) Slow excitatory transmission in rat dorsal horn: possible mediation by peptides. Brain Res. 290, 336-341.
32. 32. Wadiche J. I., Arriza J. L., Amara S. G. and Kavanaugh M. P. (1995) Kinetics of a human glutamate transporter. Neuron 14, 1019-1027.
33. 33. Willis W. D. Jr and Coggeshall R. E. (1991) Structure of the dorsal horn. In Sensory mechanisms of the spinal cord, pp. 79-151. Plenum Press, New York..
34. 34. Willis W. D. Jr and Coggeshall R. E. (1991) Functional organization of dorsal horn interneurons. In Sensory mechanisms of the spinal cord, pp. 153-215. Plenum Press, New York.
35. 35. Woolf C. J. and Fitzgerald M. (1983) The properties of neurones recorded in the superficial dorsal horn of the rat spinal cord. J. comp. Neurol. 221, 313-328.
36. 36. Woolf C. J. and King A. E. (1987) Physiology and morphology of multireceptive neurons with C-afferent inputs in the deep dorsal horn of the rat lumbar spinal cord. J. Neurophysiol. 58, 460-479.
37. 37. Yoshimura M. and Jessell T. M. (1989) Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro. J. Neurophysiol. 62, 96-108.
38. 38. Yoshimura M. and Jessell T. M. (1990) Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord. J. Physiol. 430, 315-335.
39. 39. Yoshimura M. and Nishi S. (1991) Patch clamp analysis of serotonin responses in substantia gelatinosa neurons of the rat spinal cord slice. Soc. Neurosci. Abstr. 17, 92.
40. 40. Yoshimura M. and Nishi S. (1993) Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience 53, 519-526.
41. 41. Yoshimura M., Shimizu T., Yajiri Y., Inokuchi H. and Nishi S. (1993) Primary afferent-evoked slow EPSPs and responses to substance P of dorsal horn neurons in the adult rat spinal cord slices. Regul. Pept. 46, 407-409.