GABA, glutamate and substance P-like immunoreactivity release: Effects of novel GABA(B) antagonists

British Journal of Pharmacology

Volumn 118, Issue 5, 1996, Pages 1153-1160

  Teoh, Hwee ^a,b   Malcangio, Marzia ^a,c   Bowery, Norman G ^a,d  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

CGP36742; CGP52432; CGP55845A; CGP56999A; CGP57250A; GABA; GABA(B) antagonists; Glutamate; Spinal cord; Substance P like immunoreactivity

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ARECAIDINE; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; GLUTAMIC ACID; SUBSTANCE P; [3 (3,4 DICHLOROBENZYLAMINO)PROPYL](DIETHOXYMETHYL)PHOSPHINIC ACID;

4 AMINOBUTYRIC ACID RELEASE; AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; HORMONE RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; STEREOSPECIFICITY;

EID: 0030018664     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15518.x     Document Type: Article

References (68)

1. AANONSEN, L.M. & WILCOX, G.L. (1987). Nociceptive action of excitatory amino acids in the mouse: Effects of spinally administered opioids, phencyclidine and sigma opioids. J. Pharmacol. Exp. Ther., 243, 9-19.
2. B-mediated response. Meth. Find. Exp. Clin. Pharmacol., 13, 681-686.
3. B autoreceptors in median eminence. Eur. J. Pharmacol., 118, 355-358.
4. BARBER, R.P., VAUGHAN, J.E., SAITO, K., MCLAUGHLIN, B.J. & ROBERTS, E (1978). GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord. Brain Res., 141, 35-55.
5. B receptor-mediated autoinhibition of GABA release. Naunyn Schmiedeberg's Arch. Pharmacol., 341, 88-93.
6. B receptors inhibit the release of cholecystokinin-like material from the rat spinal cord in vitro. Brain Res., 590, 255-261.
7. B antagonists: potential new drugs. Pharmacol. Commun., 2, 70-74.
8. B receptor antagonists: from synthesis to therapeutic applications. Trends Pharmacol. Sci., 14, 391-394.
9. B receptor mediated inhibition in rat spinal cord in-vitro. Br. J. Pharmacol., 111, 94P.
10. B-type in human cerebral cortex. Br. J. Pharmacol., 96, 341-346.
11. B autoreceptors in rat cortex synaptosomes: response under different depolarizing and ionic conditions. Eur. J. Pharmacol., 172, 41-49.
12. B receptors mediate inhibition of somatostatin release from cerebrocortex nerve terminals. J. Pharmacol. Exp. Ther., 259, 1103-1107.
13. B receptor subtypes in the rat cerebral cortex. J. Pharmacol. Exp. Ther., 262, 114-118.
14. B receptors. Trends Pharmacol. Sci., 14, 259-261.
15. B receptor pharmacology. Annu. Rev. Pharmacol. Toxicol., 33, 109-147.
16. B receptor binding sites in rat whole brain synaptic membranes. Br. J. Pharmacol., 78, 191-206.
17. BOWERY, N.G., HILL, D.R., HUDSON, A.L., DOBLE, A., MIDDLEMISS, D.N., SHAW, J. & TURNBULL, M. (1980). (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature, 283, 92-94.
18. BRENNAN, M.J.W., CANTRILL, R.C., OLDFIELD, M. & KROGSGAARD-LARSEN, P. (1981). Inhibition of γ-aminobutyric acid release by γ-aminobutyric acid agonist drugs. Pharmacology of the γ-aminobutyric acid autoreceptor. Mol. Pharmacol., 19, 27-30.
19. BROWN, A.G. (1982). The dorsal horn of the spinal cord. Q. J. Exp. Physiol., 17, 193-212.
20. CERVERO, F. & IGGO, A. (1980). The substantia gelatinosa of the spinal cord-a critical review. Brain, 103, 717-772.
21. CONZELMANN, U., MEYER, D.K. & SPERK, G. (1986). Stimulation of receptors of γ-aminobutyric acid modulates the release of cholecystokinin-like immunoreactivity from slices of rat neostriatum. Br. J. Pharmacol., 89, 845-852.
22. CURTIS, D.R., DUGGAN, A.W., FELIX, D. & JOHNSTON, G.A.R. (1971). Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord. Brain Res., 32, 69-96.
23. CUTTING, D.A. & JORDAN, C.C. (1975). Alternative approaches to analgesia: baclofen as a model compound. Br. J. Pharmacol., 54, 171-179.
24. B receptors on A<5 and C primary afferents. Br. J. Pharmacol., 81, 327-333.
25. DE BIASI, S & RUSTIONI, A. (1988). Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord. Proc. Natl Acad. Sci. USA, 85, 7820-7824.
26. B receptors in the central nervous system. Nature, 332, 156-158.
27. FAGG, G.E. & FOSTER, A.C. (1983). Amino acid neurotransmitters and their pathways in the mammalian central nervous system. Neuroscience., 9, 701-719.
28. FOLLENFANT, R.F. & NAKAMURA-CRAIG, M. (1992). Glutamate induces hyperalgesia in the rat paw. Br. J. Pharmacol., 106, 49P.
29. GEMIGNANI, A., PAUDICE, P., BONANNO, G. & RAITERI, M. (1994). Pharmacological discrimination between γ-aminobutyric acid type B receptors regulating cholecystokinin and somatostatin release from rat neocortex synaptosomes. Mol. Pharmacol., 46, 558-562.
30. B sites in rat brain. Nature, 290, 149-152.
31. B receptors and substance P in the mouse spinal cord. J. Pharmacol. Exp. Ther., 248, 1026-1033.
32. JEFTINIJA, S., JEFTINIJA, K., LIU, F., SKILLING, S.R., SMULLIN, D.H. & LARSON, A.A. (1991). Excitatory amino acids are released from rat primary afferent neurons in-vitro. Neurosci. Lett., 125, 191-194.
33. KANGRGA, I., JIANG, M.C. & RANDIC, M. (1991). Actions of (-)-baclofen on rat dorsal horn neurons. Brain Res., 562, 265-275.
34. KANGRGA, I., LAREW, J.S.A. & RANDIĆ, M. (1990). The effects of substance P and calcitonin gene-related peptide on the efflux of endogenous glutamate and aspartate from the rat spinal dorsal horn in-vitro. Neurosci. Lett., 108, 155-160.
35. KANGRGA, I. & RANDIĆ, M. (1991). Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice. J. Neurosci., 10, 2026-2038.
36. KERR, D.I.B., ONG, J., PRAGER, R.H., GYNTHER, B.D. & CURTIS, D.R. (1987). Phaclofen: a peripheral and central baclofen antagonist. Brain Res., 405, 150-154.
37. B autoreceptor antagonist in rat cerebral cortex. Eur. J. Pharmacol., 237, 191-195.
38. LEVY, R.A. & PROUDFIT, H.K. (1979). Analgesia produced by microinjection of baclofen and morphine at brain stem sites. Eur. J. Pharmacol., 57, 43-55.
39. LIEBMAN, J.M. & PASTOR, G. (1980). Antinociceptive effects of baclofen and muscimol upon intraventricular administration. Eur. J. Pharmacol., 61, 225-230.
40. LINDROTH, P. & MOPPER, K. (1979). High performance liquid Chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with ophthaldialdehyde. Anal. Chem., 51, 1667-16774.
41. MAGNUSON, D.S.K. & DICKENSON, A.H. (1991). Lamina-specific effects of morphine and naloxone in dorsal horn of rat spinal cord in vitro. J. Neurophysiol., 66, 1941-1950.
42. A receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro. J. Pharmacol. Exp. Ther., 266, 1490-1496.
43. B antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen. Br. J. Pharmacol., 103, 1303-1308.
44. MAO, J.-R., PRICE, D.D. & MAYER, D.J. (1994). Thermal hyperalgesia in association with the development of morphine tolerance in rats L roles of excitatory amino acid receptors and protein kinase C. J. Neurosci., 14, 2301-2312.
45. MAYER, M.L. & WESTBROOK, G.L. (1987). The physiology of excitatory amino acids in the vertebrate central nervous system. Prog. Neurobiol., 28, 197-276.
46. MITCHELL, P.R. & MARTIN, I.L. (1978). Is GABA release modulated by presynaptic receptors? Nature, 274, 904-905.
47. B antagonists attenuate the antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat. Brain Res., 607, 39-46.
48. PARPURA, V., BASARSKY, T.A., LIU, F., JEFTINIJA, K., JEFTINIJA, S. & HAYDON, P.G. (1994). Glutamate-mediated astrocyteneuron signalling. Nature, 369, 744-747.
49. B) receptor subtype. Brain Res., 604, 325-330.
50. B type. Eur. J. Pharmacol., 144, 45-52.
51. B receptors present on primary afferent terminals of the spinal cord? Nature, 307, 71-74.
52. PROUDFIT, H.K. & LEVY, R.A. (1978). Delimitation of neuronal substrates necessary for the analgesic action of baclofen and morphine. Eur. J. Pharmacol., 47, 159-166.
53. B, autoreceptors. J. Pharmacol. Exp. Ther., 250, 648-653.
54. REN, K., WILLIAMS, G.M., HYLDEN, J.L.K., RUDA, M.A. & DUBNER, R. (1992). The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioural hyperalgesia in rats. Eur. J. Pharmacol., 219, 235-243.
55. SANTIAGO, M., MACAHADO, A. & CANO, J. (1993). In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen. Br. J. Pharmacol., 109, 814-818.
56. SAWYNOK, J. (1987). GABAergic mechanisms of analgesia: an update. Pharmacol. Biochem. Behav., 26, 463-474.
57. 3H]muscimol binding sites in rat dorsal spinal cord after neonatal capsaicin treatment. Brain Res., 202, 484-487.
58. SMULLIN, D.H., SKILLING, S.R. & LARSON, A.A. (1990). Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord. Pain. 42, 93-101.
59. SORKIN, L.S. & MCADOO, D.J. (1993). Amino acids and serotonin are released into the lumbar spinal cord of the anaesthetised cat following intradermal capsaicin injections. Brain Res., 607, 89-98.
60. B antagonists on glutamate and GABA release from rat spinal cord. Br. J. Pharmacol., 114, 302P.
61. TEOH, H., FOWLER, L.J. & BOWERY, N.G. (1995b). Effect of lamotrigine on the electrically-evoked release of endogenous amino acids from slices of dorsal horn of the rat spinal cord. Neuropharmacology., 34, 1273-1278.
62. B receptor control of transmitter release in spinal cord In GABA '95: Receptors, Transporters and Metabolism ed. Tanaka, C. and Bowery, N.G., Birkhauser: Basel (in press).
63. TEOH, H., MALCANGIO, M., FOWLER, L.J. & BOWERY, N.G. (1996b). Evidence for release of glutamic acid, aspartic acid and substance P but not γ-aminobutyric acid from primary afferent fibres in rat spinal cord. Eur. J. Pharmacol., (in press).
64. WALDMEIER, P.C., WICKI, P., FELDTRAUER, J.-J. & BAUMANN, P.A. (1988a). The measurement of the release of endogenous GABA from rat brain slices by liquid chromatography with electrochemical detection. Naunyn Schmiedeberg's Arch. Pharmacol., 337, 284-288.
65. WALDMEIER, P.C., WICKI, P., FELDTRAUER, J.-J. & BAUMANN, P.A. (1988b). Potential involvement of a baclofen-sensitive autoreceptor in the modulation of the release of endogenous GABA from rat brain slices in vitro. Naunyn Schmiedeberg's Arch. Pharmacol., 337, 289-295.
66. B receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. Br. J. Pharmacol., 113, 1515-1521.
67. WATKINS, J.C. & EVANS, R.H. (1981). Excitatory amino acid transmitters. Annu. Rev. Pharmacol. Toxicol., 21, 165-204.
68. WILSON, P.R. & YAKSH, T.L. (1978). Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur. J. Pharmacol., 51, 323-330.