Characterization of Lymphocyte Function-Associated Antigen 1 (LFA-1)-Deficient T Cell Lines: The αL and β2 Subunits are Interdependent for Cell Surface Expression

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 273-279

  Weber, Kim S C ^a   York, Michael R ^a   Springer, Timothy A ^b   Klickstein, Lloyd B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MEMBRANE PROTEIN; PEPTIDE FRAGMENT;

ARTICLE; BIOSYNTHESIS; CELL LINE; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE;

ANTIGENS, CD18; CELL LINE; HUMANS; INTEGRINS; JURKAT CELLS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; T-LYMPHOCYTES;

EID: 0030639837     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346:425.
2. Hynes, R. O. 1992. Integrins: versatility, modulation and signaling in cell adhesion. Cell 69:11.
3. Arnaout, M. A. 1990. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 75:1037.
4. 2, binds preferentially to ICAM-3. Immunity 3:683.
5. Larson, R. S., A. L. Corbi, L. Berman, and T. A. Springer. 1989. Primary structure of the leukocyte function-associated molecule-1 α subunit: an integrin with an embedded domain defining a protein superfamily. J. Cell. Biol. 108:703.
6. Kishimoto, T. K., K. O'Connor, A. Lee, T. M. Roberts, and T. A. Springer. 1987. Cloning of the β subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell 48:681.
7. Corbi, A. L., R. S. Larson, T. K. Kishimoto, T. A. Springer, and C. C. Morton. 1988. Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. J. Exp. Med. 167:1597.
8. Kishimoto, T. K., R. S. Larson, A. L. Corbi, M. L. Dustin, D. E. Staunton, and T. A. Springer. 1989. Leukocyte integrins. Adv. Immunol. 46:149.
9. Anderson, D. C., and T. A. Springer. 1987. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu. Rev. Med. 38:175.
10. Hibbs, M. L., A. J. Wardlaw, S. A. Stacker, D. C. Anderson, A. Lee, T. M. Roberts, and T. A. Springer. 1990. Transfection of cells from patients with leukocyte adhesion deficiency with an integrin β subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function. J. Clin. Invest. 85:674.
11. Kishimoto, T. K., N. Hollander, T. M. Roberts, D. C. Anderson, and T. A. Springer. 1987. Heterogeneous mutations in the β subunit common to the LFA-1, Mac-1 and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell 50:193.
12. Dimanche-Boutrel, M., A. Guyot, G. De Saint-Basile, A. Fischer, C. Griscelli. and B. Lissowska-Grospierre. 1988. Heterogeneity in the molecular defect leading to the leukocyte adhesion deficiency. Eur. J. Immunol. 18:1575.
13. Kishimoto, T. K., K. O'Connor, and T. A. Springer. 1989. Leukocyte adhesion deficiency. J. Biol. Chem. 264:3588.
14. Dimanche, M., F. Le Deist, A. Fischer, M. A. Arnaout, C. Griscelli, and B. Lissowska-Grospierre. 1987. LFA-1 β-chain synthesis and degradation in patients with leukocyte adhesive proteins deficiency. Eur. J. Immunol. 17:417.
15. Miller, L. J., and T. A. Springer. 1987. Biosynthesis and glycosylation of p150,95 and related leukocyte adhesion proteins. J. Immunol. 139:842.
16. Sastre, L., T. K. Kishimoto, C. Gee, T. Roberts, and T. A. Springer. 1986. The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. J. Immunol. 137:1060.
17. Ho, M. K., and T. A. Springer. 1983. Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function. J. Biol. Chem. 258:2766.
18. Larson, R. S., M. L. Hibbs, and T. A. Springer. 1990. The leukcyte integrin LFA-1 reconstituted by cDNA tranfection in a nonhematopoietic cell line is functionally active and not transiently regulated. Cell Regul. 1:359.
19. 2 are involved in endoplasmic reticulum retention, dimerization, and cytoskeletal association. J. Immunol. 155:1252.
20. Arnaout, A. M., N. Dana, S. K. Gupta, D. G. Jenen, and D. M. Fathalla. 1990. Point mutations impairing cell surface expression of the common β subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-Cam) deficiency. J. Clin. Invest. 85:977.
21. Waralaw, A. J., M. L. Hibbs, S. A. Stacker, and T. A. Springer. 1990. Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates. J. Exp. Med. 172:315.
22. Nelson, C., H. Rabb, and M. A. Arnaout. 1991. Genetic causes of leukocyte adhesion molecule deficiency. J. Biol. Chem. 267:3351.
23. Sanchez-Madrid, F., A. M. Krensky, C. F. Ware, E. Robbins, J. L. Strominger, S. J. Burakoff, and T. A. Springer. 1982. Three distinct antigens associated with human T lymphocyte-mediated cytolysis: LFA-1, LFA-2 and LFA-3. Proc. Natl. Acad. Sci. USA 79:7489.
24. de Fougerolles, A. R., and T. A. Springer. 1992. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J. Exp. Med. 175:185.
25. Changelian, P. S., R. M. Jack, L. A. Collins, and D. T. Fearon. 1985. PMA induces the ligand-independent internalization of CR1 on human neutrophils. J. Immunol. 134:1851.
26. Petruzzelli, L., L. Maduzia, and T. A. Springer. 1995. Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18. J. Immunol. 155:854.
27. Petruzzelli, L., J. Luk, and T. A. Springer. 1993. Adhesion structure subpanel 5, leukocyte integrins: CD11a, CD11b, CD11c, and CD18. In Leukocyte Typing V, Vol 2. S. F. Schlossman, L. Boumsell, W. Gilks, J. M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T. F. Tedder, and R. F. Todd, eds. Oxford University Press, New York, p. 1585.
28. Yelton, D. E., C. Desaymard, and M. D. Scharff. 1981. Use of monoclonal antimouse immunoglobulin to detect mouse antibodies. Hybridoma 1:5.
29. Hollander, N., P. Selvaraj, and T. A. Springer. 1988. Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphotidylinositol-anchored proteins. J. Biol. Chem. 141:4283.
30. Wysocki, L. J., and V. L. Sato. 1978. "Panning" for lymphocytes: a method for cell selection. Proc. Natl. Acad. Sci. USA 75:2844.
31. Fraker, P. J., and J. C. Speck. 1978. Protein and cell membrane iodination with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3.6-diphenyl glycoluril. Biochem. Biophys. Res. Commun. 80:849.
32. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
33. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
34. Thomas, P. S. 1980. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77:5201.
35. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503.
36. de Fougerolles, A. R., L. B. Klickstein, and T. A. Springer. 1993. Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1. J. Exp. Med. 177:1187.
37. Peden, K., O. Hurko, and G. Tennekoon. 1987. Establishment of cell lines from primary cultures by transfection with SV40 large T antigen gene. Prog. Clin. Biol. Res. 253:101.
38. Diamond, M. S., D. E. Staunton, A. R. de Fougerolles, S. A. Stacker, J. Garcia-Aguilar, M. L. Hibbs, and T. A. Springer. 1990. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J. Cell. Biol. 111:3129.
39. van Zeeland, A. A., J. G. Jansen G. R. Mohn, H. Vrieling, A. D. Tates and P. H. M. Lohman. 1995. Detection of point mutations in T lymphocytes. Clin. Chem. 41:1841.
40. Natarajan, A. T., J. W. I. M. Simons, E. W. Vogel, and A. A. van Zeeland. 1984. Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. Mutat. Res 128:31.
41. Pingel, J. T., and M. L. Thomas. 1989. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Cell 58:1055.
42. Koretzky, G. A., J. Picus, T. Schultz, and A. Weiss. 1991. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc. Natl. Acad. Sci. USA 88:2037.
43. Strauss, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585.
44. Miyata, T., J. Takeda, Y. Iida, N. Yamada, N. Inoue, M. Takahashi, K. Maeda, T. Kitani, and T. Kinoshita. 1993. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science 259:1318.
45. Koretzky, G. A., J. Picus, M. L. Thomas, and A. Weiss. 1990. Tyrosine phophatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346:66.
46. Rajagopalan, S., Y. Xu, and M. B. Brenner. 1994. Retention of unassembled components of integral membrane proteins by calnexin. Science 263:387.
47. 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide. J. Exp. Med. 180:2163.
48. Rojiani, M. V., B. B. Finlay, V. Gray, and S. Dedhar. 1991. In vitro interaction of a polypeptde homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin α subunits. Biochemistry 30:9859.
49. Coppolino, M., C. Leung-Hagesteijn, S. Dedhar, and J. Wilkins. 1995. Inducible interaction of integrin α2β1 with calreticulin. J. Biol. Chem. 270:23132.
50. Schmits, R., T. M. Kundig, D. M. Baker, G. Shumaker, J. J. L. Simard, G. Duncan, A. Wakeham, A. Shahmian, A. van der Heiden, M. F. Bachmann, P. S. Ohashi, T. W. Mak, and D. D. Hickstein. 1996. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183:1415.
51. Simsek, S., H. Heyboer, L. G. de Bruijne-Admiraal, R. Goldschmeding, H. Th. M Cuijpers, and A. E. G. Kr. von dem Borne. 1993. Glanzmann's trombasthenia caused by homozygosity for a splice defect that leads to deletion of the first coding exon of the glycoprotein IIIa mRNA. Blood 81:2044.
52. Wilcox, D. A., C. M. Paddock, S. Lyman, J. Cox Gill, and P. J. Newman. 1995. Glanzmann thrombasthenia resulting from a single amino acid substitut,™ between the second and third calcium-binding domains of GPIIb. J. Clin. Invest. 95:1553.
53. Wilson, J. M., A. I. Ping, J. C. Krauss, L. Mayo-Bond, C. E. Rogers, D. C. Anderson, and R. F. Todd III. 1990. Correction of CD 18-deficient T lymphocytes by retrovirus-mediated gene transfer. Science 248:1413.