Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking

Trends in Pharmacological Sciences

Volumn 21, Issue 5, 2000, Pages 175-180

  Kallal, Lorena ^a   Benovic, Jeffrey L ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN;

CHIMERA; DESENSITIZATION; DIFFUSION; ENDOSOME; HUMAN; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; REVIEW;

ANIMALS; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEINS; HUMANS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 0034193130     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01477-2     Document Type: Review

References (55)

1. Bargmann C.I. Neurobiology of the Caenorhabditis elegans genome. Science. 282:1998;2028-2033.
2. Neer E.J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 80:1995;249-257.
3. Krupnick J.G., Benovic J.L. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu. Rev. Pharmacol. Toxicol. 38:1998;289-319.
4. Ferguson S.S.G.et al. G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. Can. J. Physiol. Pharmacol. 74:1996;1095-1110.
5. Yu S.S.et al. β-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. J. Biol. Chem. 268:1993;337-341.
6. Pak Y.et al. Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein. Mol. Pharmacol. 50:1996;1214-1222.
7. Garland A.M.et al. Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. Mol. Pharmacol. 49:1996;438-446.
8. s-coupled receptor responses. Br. J. Pharmacol. 125:1998;1594-1600.
9. 2-adrenergic receptor dephosphorylation by vesicular acidification. J. Biol. Chem. 272:1997;5-8.
10. Mukherjee S.et al. Endocytosis. Physiol. Rev. 77:1997;759-803.
11. Cao T.T.et al. Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pits. J. Biol. Chem. 273:1998;24592-24602.
12. Vickery R.G., von Zastrow M. Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J. Cell Biol. 144:1999;31-43.
13. Milligan G. Exploring the dynamics of regulation of G protein-coupled receptors using green fluorescent protein. Br. J. Pharmacol. 128:1999;501-510.
14. Prasher D.C.et al. Primary structure of the Aequorea victoria green-fluorescent protein. Gene. 111:1992;229-233.
15. Tsien R.Y. The green fluorescent protein. Annu. Rev. Biochem. 67:1998;509-544.
16. Matz M.V.et al. Fluorescent proteins from nonbioluminescent anthozoa species. Nat. Biotechnol. 17:1999;969-973.
17. Tarasova N.I.et al. Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A. J. Biol. Chem. 272:1997;14817-14824.
18. 2-adrenergic receptor. J. Biol. Chem. 273:1998;322-328.
19. Barak L.S.et al. Internal trafficking and surface mobility of a functionally intact β-2-adrenergic receptor-green fluorescent protein conjugate. Mol. Pharmacol. 51:1997;177-184.
20. Drmota T.et al. Real time vizualization of agonist-mediated redistribution and internalization of a green fluorescent protein-tagged form of the thyrotropin-releasing hormone receptor. J. Biol. Chem. 273:1998;24000-24008.
21. 1-adrenoceptors irrespective of the subtype. Mol. Pharmacol. 52:1997;764-770.
22. 2 receptor in Madin Darby canine kidney cells. FEBS Lett. 441:1998;170-176.
23. Xiao Z.et al. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J. Cell Biol. 139:1997;365-374.
24. Nelson S.et al. Characterization of an intrinsically fluorescent gonadotropin-releasing hormone receptor and effects of ligand binding on receptor lateral diffusion. Endocrinology. 140:1999;950-957.
25. Stefan C.J., Blumer K.J. A syntaxin homolog encoded by VAM3 mediates down-regulation of a yeast G protein-coupled receptor. J. Biol. Chem. 274:1999;1835-1841.
26. Slice L.W.et al. Visualization of internalization and recycling of the gastrin releasing peptide receptor-green fluorescent protein chimera expressed in epthelial cells. Recept. Channels. 6:1998;201-212.
27. Liu C.H.et al. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol. Biol. Cell. 10:1999;1179-1190.
28. Awaji T.et al. Real-time optical monitoring of ligand-mediated internalization of α1b-adrenoceptor with green fluorescent protein. Mol. Endocrinol. 12:1998;1099-1111.
29. McConalogue K.et al. Substance P-induced trafficking of β-arrestins. (The role of β-arrestins in endocytosis of the neurokinin-1 receptor). J. Biol. Chem. 274:1999;16257-16268.
30. 2+ activation of the human calcium sensing receptor. J. Biol. Chem. 273:1998;29712-29718.
31. Deng H.et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 381:1996;661-666.
32. Tarasova N.I.et al. Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4. J. Biol. Chem. 273:1998;15883-15886.
33. Amara A.et al. HIV coreceptor downregulation as antiviral principle: SDF-1(α)-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J. Exp. Med. 186:1997;139-146.
34. Hebert T.E., Bouvier M. Structural and functional aspects of G protein-coupled receptor oligomerization. Biochem. Cell. Biol. 76:1998;1-11.
35. Miesenböck G.et al. Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature. 394:1998;192-195.
36. Ellenberg J.et al. Two-color green fluorescent protein time-lapse imaging. Biotechniques. 25:1998;838-846.
37. Ellenberg J.et al. Dual-colour imaging with GFP variants. Trends Cell. Biol. 9:1999;52-56.
38. Pollok B.A., Heim R. Using GFP in FRET-based applications. Trends Cell Biol. 9:1999;57-60.
39. Goodman O.B.J.et al. β-arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor. Nature. 383:1996;447-450.
40. Barak L.S.et al. A β-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. J. Biol. Chem. 272:1997;27497-27500.
41. Sengupta P.et al. odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell. 84:1996;899-909.
42. Suter K.J.et al. Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology. Endocrinology. 141:2000;412-419.
43. 2-adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc. Natl. Acad. Sci. U. S. A. 96:1999;3712-3717.
44. McLean A.J.et al. Visualizing differences in ligand regulation of wild-type and constitutively active mutant β(2)-adrenoceptor-green fluorescent protein fusion proteins. Mol. Pharmacol. 56:1999;1182-1191.
45. Barlic J.et al. β-arrestins regulate interleukin-8-induced CXCR1 internalization. J. Biol. Chem. 274:1999;16287-16294.
46. 2/M. Proc. Natl. Acad. Sci. U. S. A. 95:1998;12334-12339.
47. Yun C.-W.et al. G-protein coupled receptor from yeast Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 240:1997;287-292.
48. Lembo P.M.et al. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat. Cell Biol. 1:1999;267-271.
49. Doherty A.J.et al. Rapid internalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor. Biochem. J. 341:1999;415-422.
50. Déry O.et al. Trafficking of proteinase-activated receptor-2 and β-arrestin-1 tagged with green fluorescent protein. (β-arrestin-dependent endocytosis of a proteinase receptor). J. Biol. Chem. 274:1999;18524-18535.
51. Cheng Y., Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 273:1998;35008-35015.
52. Walker J.K.et al. Properties of secretin receptor internalization differ from those of the β(2)-adrenergic receptor. J. Biol. Chem. 274:1999;31515-31523.
53. Odorizzi G.et al. Fab1 PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell. 95:1998;847-858.
54. qα /G11α induced by agonist stimulation. Biochem. J. 340:1999;529-538.
55. Vieira J.et al. Functional analysis of the human cytomegalovirus gene by insertion mutagenesis with the green fluorescent protein gene. J. Virol. 72:1998;8158-8165.