메뉴 건너뛰기




Volumn 1, Issue 2, 2000, Pages 115-123

Current pharmacogenomic approaches to clinical drug development

Author keywords

Clinical trials; Drug metabolism; Drug metabolism enzymes; Pharmacogenetics; Pharmacogenomics; Polymorphisms; Single nucleotide polymorphisms (SNPs)

Indexed keywords

CLINICAL PHARMACOLOGY; CLINICAL TRIAL; GENOTYPE; HUMAN; METHODOLOGY; PHARMACOGENETICS; REVIEW;

EID: 0034189084     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/14622416.1.2.115     Document Type: Review
Times cited : (29)

References (25)
  • 1
    • 0030666917 scopus 로고    scopus 로고
    • Pharmacogenetics: 65 candles on the cake
    • NEBERT DW: Pharmacogenetics: 65 candles on the cake. Pharmacogenetics (1997) 7:435-440. Excellent historical perspective of pharmacogenetics.
    • (1997) Pharmacogenetics , vol.7 , pp. 435-440
    • Nebert, D.W.1
  • 2
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenetics: Translating functional genomics into rational therapeutics
    • EVANS WE, RELLING MV: Pharmacogenetics: translating functional genomics into rational therapeutics. Science (1999) 286:487-491. Excellent review article.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 3
    • 0032544336 scopus 로고    scopus 로고
    • Genetic variation as a guide to drug development
    • KLEYN PW, VESELL ES: Genetic variation as a guide to drug development. Science (1998) 281:1820-1821. Review of using a pharmacogenomic approach to drug development.
    • (1998) Science , vol.281 , pp. 1820-1821
    • Kleyn, P.W.1    Vesell, E.S.2
  • 4
    • 1242316022 scopus 로고    scopus 로고
    • The pharmacogenomics challenge-the only option is how and when you participate
    • March
    • BHANDARIM, GARG R, GLASSMAN R, MA P: The pharmacogenomics challenge-the only option is how and when you participate. In Vivo (March 1999) 17:36-41. Excellent review of benefits and risks using pharmacogenomics during drug development.
    • (1999) In Vivo , vol.17 , pp. 36-41
    • Bhandari, M.1    Garg, R.2    Glassman, R.3    Ma, P.4
  • 5
    • 0032609247 scopus 로고    scopus 로고
    • Genetics: An explosion of knowledge is transforming clinical practice
    • COLLINS FS: Genetics: an explosion of knowledge is transforming clinical practice. Geriatrics (1999) 54:41-47. Application of genetic testing to enhance medical practice including challenges and underlying concerns.
    • (1999) Geriatrics , vol.54 , pp. 41-47
    • Collins, F.S.1
  • 6
    • 0031742831 scopus 로고    scopus 로고
    • Relevance of pheno- and genotyping in clinical drug development
    • ZUHLSDORF MT: Relevance of pheno- and genotyping in clinical drug development. Int. J. Clin. Pharmacol. Ther. (1998) 36(11):607-612. Advantages and disadvantages of phenotyping and genotyping during drug development.
    • (1998) Int. J. Clin. Pharmacol. Ther. , vol.36 , Issue.11 , pp. 607-612
    • Zuhlsdorf, M.T.1
  • 7
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
    • GRIESE EU, Zanger UM, Brudermanns U et al: Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics (1998) 8:15-26.
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.U.1    Zanger, U.M.2    Brudermanns, U.3
  • 8
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • SACHSE C, BROCKMOLLER J, STEFFEN B, ROOTS I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. (1997) 60:284-295.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Steffen, B.3    Roots, I.4
  • 9
    • 0026472355 scopus 로고
    • Polymorphism of dextromethorphan metabolism: Relationships between phenotype, genotype and response to the administration of encainlde in humans
    • FUNCK-BRENTANO C, THOMAS G, JACQZ-AIGRAIN E et al.: Polymorphism of dextromethorphan metabolism: relationships between phenotype, genotype and response to the administration of encainlde in humans. J. Pharmacol. Exp. Ther.(1992) 263:780-786.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 780-786
    • Funck-Brentano, C.1    Thomas, G.2    Jacqz-Aigrain, E.3
  • 11
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients. A meta-analysis of prospective studies
    • LAZAROU J, POMERANZ BH, COREY PN: Incidence of adverse drug reactions in hospitalized patients. A meta-analysis of prospective studies. JAMA (1998) 279:1200-1205.
    • (1998) JAMA , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 12
    • 0033563196 scopus 로고    scopus 로고
    • Responsibilities of clinical pharmacology in the early phase of drug development
    • KUHLMANN J: Responsibilities of clinical pharmacology in the early phase of drug development. Med. Klin. (1999) 94(5):290-299. Outlines the importance of using pharmacogenetics when assessing the clinical pharmacology of new drugs.
    • (1999) Med. Klin. , vol.94 , Issue.5 , pp. 290-299
    • Kuhlmann, J.1
  • 13
    • 10544248170 scopus 로고    scopus 로고
    • The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: Screening cost and influence on clinical outcomes in psychiatry
    • CHEN S, CHOU W-H, BLOUIN RA et al.: The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening cost and influence on clinical outcomes in psychiatry. Clin. Pharmacol. Ther. (1996) 60:522-534. Documents the concordance between CYP2D6 genotyping and phenotyping. Excellent review of pharmacoeconomic justification for genotyping.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 522-534
    • Chen, S.1    Chou, W.-H.2    Blouin, R.A.3
  • 14
    • 0033782224 scopus 로고    scopus 로고
    • Prospective genotyping as an exclusion crierion for enrollment of a Phase III clinical trial
    • accepted April
    • MURPHY MP, BEAMAN ME, CLARK LS et al.: Prospective genotyping as an exclusion crierion for enrollment of a Phase III clinical trial. Pharmacogenetics (accepted April 2000). Case study of prospective genotyping during Phase III clinical trials highlighting advantages in patient safety and efficiency of drug development.
    • (2000) Pharmacogenetics
    • Murphy, M.P.1    Beaman, M.E.2    Clark, L.S.3
  • 15
    • 0020662811 scopus 로고
    • The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine
    • BERTILSSON L, ABERG-WISTEDT A: The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine. Br. J. Clin. Pharm. (1983)15:388-390.
    • (1983) Br. J. Clin. Pharm. , vol.15 , pp. 388-390
    • Bertilsson, L.1    Aberg-Wistedt, A.2
  • 16
    • 0027471030 scopus 로고
    • Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: A case report
    • BLUHM RE, WILKINSON GR, SHELTON R, BRANCH RA: Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report. Clin. Pharmacol. Ther. (1993) 53:89-95.
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 89-95
    • Bluhm, R.E.1    Wilkinson, G.R.2    Shelton, R.3    Branch, R.A.4
  • 18
    • 0029926056 scopus 로고    scopus 로고
    • Reduced sensitivity to saquinavir: An update on genotyping from Phase I/II trials
    • JACOBSEN H, HAENGGI M, OTT M et al.: Reduced sensitivity to saquinavir: an update on genotyping from Phase I/II trials. Antiviral Res. (1996) 29(1):95-97.
    • (1996) Antiviral Res. , vol.29 , Issue.1 , pp. 95-97
    • Jacobsen, H.1    Haenggi, M.2    Ott, M.3
  • 19
    • 0032552167 scopus 로고    scopus 로고
    • Correlation of response to treatment and HIV genotypic changes during Phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy
    • RACE E, GILBERT SM, SHELDON JG et al.: Correlation of response to treatment and HIV genotypic changes during Phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy. AIDS (1998) 12(12):1465-1474.
    • (1998) AIDS , vol.12 , Issue.12 , pp. 1465-1474
    • Race, E.1    Gilbert, S.M.2    Sheldon, J.G.3
  • 20
    • 0033606540 scopus 로고    scopus 로고
    • Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomized controlled trial
    • DURANT J, CLEVENBERGH P, HALFON P et al.: Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomized controlled trial. Lancet (1999) 353:2195-2199.
    • (1999) Lancet , vol.353 , pp. 2195-2199
    • Durant, J.1    Clevenbergh, P.2    Halfon, P.3
  • 21
    • 0031466866 scopus 로고    scopus 로고
    • Association between genetic polymorphisms of the beta2-adrenoreceptor and response to albuterol in children with and without a history of wheezing
    • MARTINEZ FD, GRAVES PE, BALDINI M, SOLOMON S, ERICKSON R: Association between genetic polymorphisms of the beta2-adrenoreceptor and response to albuterol in children with and without a history of wheezing. J. Clin. Invest. (1997) 100(12):3184-3188.
    • (1997) J. Clin. Invest. , vol.100 , Issue.12 , pp. 3184-3188
    • Martinez, F.D.1    Graves, P.E.2    Baldini, M.3    Solomon, S.4    Erickson, R.5
  • 22
    • 0030970412 scopus 로고    scopus 로고
    • Alzheimer's disease: Clinical implications of the apolipoprotein E genotype
    • FARLOW MR: Alzheimer's disease: clinical implications of the apolipoprotein E genotype. Neurology (1997) 48(Suppl. 6):S30-S34.
    • (1997) Neurology , vol.48 , Issue.6 SUPPL.
    • Farlow, M.R.1
  • 23
    • 0031736757 scopus 로고    scopus 로고
    • Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine
    • SMERALDI E, ZANARDI R, BENEDETTI F, DI BELLA D, PEREZ J, CATALANO M: Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiat. (1998) 3:508-511.
    • (1998) Mol. Psychiat. , vol.3 , pp. 508-511
    • Smeraldi, E.1    Zanardi, R.2    Benedetti, F.3    Di Bella, D.4    Perez, J.5    Catalano, M.6
  • 24
    • 85037447015 scopus 로고    scopus 로고
    • Case study: Genetech and the development of Herceptin
    • European Centre for Pharmaceutical Information, London, England
    • SHAK S: Case study: Genetech and the development of Herceptin. Second Annual Pharmacogenomics Event. European Centre for Pharmaceutical Information, London, England (2000).
    • (2000) Second Annual Pharmacogenomics Event
    • Shak, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.