Combinatorial solid-phase synthesis of hapalosin mimetics

Journal of Combinatorial Chemistry

Volumn 2, Issue 2, 2000, Pages 143-150

  Olsen, Jacob A ^a   Jensen, Knud J ^a   Nielsen, John ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; DEPSIPEPTIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; HAPALOSIN; LACTAM; LACTONE; PEPTIDE LIBRARY;

ALKYLATION; ARTICLE; CHEMICAL MODEL; CHEMISTRY; ORGANIC CHEMISTRY; SYNTHESIS;

ALKYLATION; ANILINE COMPOUNDS; CHEMISTRY, ORGANIC; DEPSIPEPTIDES; INDICATORS AND REAGENTS; LACTAMS; LACTONES; MODELS, CHEMICAL; PEPTIDE LIBRARY;

EID: 0034150453     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990062p     Document Type: Article

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28. Formation of PyBOP' ed byproduct 4 could be due to use of more dry DMF for the library synthesis or a more concentrated coupling solution.
29. After completion of the library synthesis, we observed that mild treatment with 2-methyl-1-aminopropane in DMF for 30 min also removed the O-modification.